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View article: Estimating additive interaction in 2-stage individual participant data meta-analysis
Estimating additive interaction in 2-stage individual participant data meta-analysis Open
Individual participant data (IPD) meta-analysis provides important opportunities to study interaction and effect modification for which individual studies often lack power. While previous meta-analyses have commonly focused on multiplicati…
View article: Cohort profile: the CARTaGENE Cohort Nutrition Study (Quebec, Canada)
Cohort profile: the CARTaGENE Cohort Nutrition Study (Quebec, Canada) Open
Purpose To address emerging nutritional epidemiological research questions, data from contemporary cohorts are needed. CARTaGENE is the largest ongoing prospective cohort study of men and women in Québec, Canada. Dietary information was co…
View article: The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis
The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis Open
Background Although behavioral mechanisms in the association among depression, anxiety, and cancer are plausible, few studies have empirically studied mediation by health behaviors. We aimed to examine the mediating role of several health …
View article: Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta‐analysis
Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta‐analysis Open
Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in…
Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data Open
Non-cancer BEs spanned three orders of magnitude. The lowest BEs were for EGVs based on developmental endpoints in epidemiological studies. Concentrations in Canadian/U.S. national surveys were higher than or close to BEs for the most rece…
View article: Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis
Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis Open
Background Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing th…
Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard Open
Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parti…
P-368 Occupational Biological Limit derivation process and Biological Limit Values for several priority substances Open
Introduction Biomonitoring and atmospheric metrology are complementary approaches to assess occupational exposure to chemicals. The ANSES working group on biomarkers of exposure (WGBME) has developed an approach to derive Biological Limit …
RF-367 Occupational exposure to agents and substances in the CARTaGENE cohort Open
Introduction Occupational exposures are related to occupational diseases burden and increased susceptibility to health issues. The joint assessment of occupational exposure and disease outcome is the key to accelerate breakthroughs in occu…
Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses Open
Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, gener…
Validation of breast cancer risk assessment tools on a French-Canadian population-based cohort Open
Objectives Evaluate the accuracy of the Breast Cancer Risk Assessment Tool (BCRAT), International Breast Cancer Intervention Study risk evaluation tool (IBIS), Polygenic Risk Scores (PRS) and combined scores (BCRAT+PRS and IBIS +PRS) to pr…
Additional file 2 of Epidemiological characteristics of the COVID-19 spring outbreak in Quebec, Canada: a population-based study Open
Additional file 2 Supplementary files (informed consent and questionnaire).
Epidemiological and socio-economic characteristics of the COVID-19 spring outbreak in Quebec, Canada: A population-based study Open
Background By mid-July 2020, more than 108,000 COVID-19 cases had been diagnosed in Canada with more than half in the province of Quebec. To be prepared for a potential second wave of COVID-19 in the fall, it seems of utmost importance to …
Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort Open
With the increasing use of polygenic risk scores (PRS) there is a need for adapted methods to evaluate the predictivity of these tools. In this work, we propose a new pseudo-R 2 criterion to evaluate PRS predictive accuracy for time-to-eve…
Is there an agreement between self-reported medical diagnosis in the CARTaGENE cohort and the Québec administrative health databases? Open
BackgroundPopulation health studies often use existing databases that are not necessarily constituted for research purposes. The question arises as to whether different data sources such as in administrative health data (AHD) and self-repo…
Evaluation of human biomonitoring data in a health risk based context: An updated analysis of population level data from the Canadian Health Measures Survey Open
In order to characterize exposure of the Canadian population to environmental chemicals, a human biomonitoring component has been included in the Canadian Health Measures Survey (CHMS). This nationally-representative survey, launched in 20…
The Establishment of the Household Air Pollution Consortium (HAPCO) Open
Household air pollution (HAP) is of public health concern, with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP…
Green space associations with mental health and cognitive function Open
Background: Urban green space may be important to mental health, but the association between long-term green space exposures and depression, anxiety, and cognitive function in adults remains unknown. Methods: We examined 8,144 adults enrol…