Noof Aloufi
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View article: Prevalence of e-cigarette Use with different flavors in the Medina region of Saudi Arabia
Prevalence of e-cigarette Use with different flavors in the Medina region of Saudi Arabia Open
Our study is useful for identifying the preferences towards e-cigarette usage within a population and monitoring emerging trends, particularly among young adults. Researching regional preferences for e-cigarette flavors might help to direc…
View article: Investigating the potential role of T helper 17 cells among women experiencing overweight and obesity and their possible therapeutic targeting of the RORγt molecule
Investigating the potential role of T helper 17 cells among women experiencing overweight and obesity and their possible therapeutic targeting of the RORγt molecule Open
View article: Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis Open
BACKGROUND: Invariant natural killer T (iNKT) cells are an immune subset that purportedly link the adaptive and the innate arms of the immune system. Importantly, iNKT cells contribute to anti-cancer immunity in different types of hematolo…
View article: Standardized Cannabis Smoke Extract Induces Inflammation in Human Lung Fibroblasts
Standardized Cannabis Smoke Extract Induces Inflammation in Human Lung Fibroblasts Open
Cannabis (marijuana) is the most commonly used illicit product in the world and is the second most smoked plant after tobacco. There has been a rapid increase in the number of countries legalizing cannabis for both recreational and medicin…
View article: Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression
Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression Open
Patients with COPD may be at an increased risk for severe illness from COVID-19 because of ACE2 upregulation, the entry receptor for SARS-CoV-2. Chronic exposure to cigarette smoke, the main risk factor for COPD, increases pulmonary ACE2. …
View article: HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia
HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia Open
View article: Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts
Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts Open
View article: Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease Open
Chronic obstructive pulmonary disease (COPD) is an incurable and prevalent respiratory disorder that is characterized by chronic inflammation and emphysema. COPD is primarily caused by cigarette smoke (CS). CS alters numerous cellular proc…
View article: The Regulation of Pulmonary ACE2 by Human Antigen R (HuR)
The Regulation of Pulmonary ACE2 by Human Antigen R (HuR) Open
COVID-19 has rapidly spread through the world, and is caused by SARS-CoV-2. Patients with chronic obstructive pulmonary disease (COPD) face an increased risk for severe illness from COVID-19 because of angiotensin-converting enzyme 2 (ACE2…
View article: Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production
Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production Open
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive extracellular matrix (ECM) deposition and activation of α‐SMA‐expressing myofibroblasts. Human antigen R (HuR) is an RNA binding protein that prom…
View article: The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress
The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress Open
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose physiological function is poorly understood. The AhR is highly expressed in barrier organs such as the skin, intestine, and lung. The lungs are continuous…
View article: Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19
Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19 Open
The COVID-19 pandemic is associated with severe pneumonia and acute respiratory distress syndrome leading to death in susceptible individuals. For those who recover, post-COVID-19 complications may include development of pulmonary fibrosis…