Noora M. Scheinin
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View article: Gestational diabetes mellitus and children’s social-emotional development, behavioral problems, and psychological adjustment
Gestational diabetes mellitus and children’s social-emotional development, behavioral problems, and psychological adjustment Open
Background This longitudinal cohort study investigated whether gestational diabetes mellitus (GDM) is associated with 2- and 5-year-old children’s social-emotional development and whether child sex moderates the association. Methods FinnBr…
View article: Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants
Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants Open
Background Maternal pre-pregnancy obesity may negatively affect offspring outcomes, including neurodevelopment. This study examined the relationship between maternal pre-pregnancy body mass index (MBMI) and the microstructure of the hippoc…
View article: Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity
Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity Open
Background It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring’s brain in a manne…
View article: Neonatal Amygdala Mean Diffusivity: A Potential Predictor of Emotional Face Perception
Neonatal Amygdala Mean Diffusivity: A Potential Predictor of Emotional Face Perception Open
The ability to differentiate between different facial expressions is an important part of human social and emotional development that begins in infancy. Studies have shown that within the first year of life, infants develop a distinctive a…
View article: Negative associations between maternal prenatal hair cortisol and child socioemotional problems
Negative associations between maternal prenatal hair cortisol and child socioemotional problems Open
View article: Trajectories of maternal depressive and anxiety symptoms and child's socio-emotional outcome during early childhood
Trajectories of maternal depressive and anxiety symptoms and child's socio-emotional outcome during early childhood Open
Maternal symptoms of depression and anxiety during pregnancy and early postnatal years are suggested to impose differential negative effects on child's socio-emotional development depending on the characteristics of the symptoms, such as t…
View article: Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity
Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity Open
Background/Objectives It is well-established that parental obesity is a strong risk factor for associates with offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing o…
View article: Infants' sex affects neural responses to affective touch in early infancy
Infants' sex affects neural responses to affective touch in early infancy Open
Social touch is closely related to the establishment and maintenance of social bonds in humans, and the sensory brain circuit for gentle brushing is already active soon after birth. Brain development is known to be sexually dimorphic, but …
View article: Effect of number of diffusion encoding directions in neonatal diffusion tensor imaging using Tract‐Based Spatial Statistical analysis
Effect of number of diffusion encoding directions in neonatal diffusion tensor imaging using Tract‐Based Spatial Statistical analysis Open
Diffusion tensor imaging (DTI) has been used to study the developing brain in early childhood, infants and in utero studies. In infants, number of used diffusion encoding directions has traditionally been smaller in earlier studies down to…
View article: Childhood trauma and fear of childbirth: findings from a birth cohort study
Childhood trauma and fear of childbirth: findings from a birth cohort study Open
The aim of this study is to investigate if experiencing childhood trauma (emotional abuse, emotional neglect, physical abuse, physical neglect, or sexual abuse) or a greater total burden of childhood trauma increase the risk of fear of chi…
View article: Infant Left Amygdala Volume Is Negatively Associated with Fecal Microbiota Diversity
Infant Left Amygdala Volume Is Negatively Associated with Fecal Microbiota Diversity Open
Introduction Rodent studies have addressed the importance of early life gut microbiota in the development of emotional and social functioning. Studies in human infants are still scarce, but associations with cognition and temperament have …
View article: Prenatal maternal depressive symptoms are associated with neonatal left amygdala microstructure in a sex‐dependent way
Prenatal maternal depressive symptoms are associated with neonatal left amygdala microstructure in a sex‐dependent way Open
Exposures to prenatal maternal depressive symptoms (PMDS) may lead to neurodevelopmental changes in the offspring in a sex‐dependent way. Although a connection between PMDS and infant brain development has been established by earlier studi…
View article: Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system
Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system Open
Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to ad…
View article: Effect of number of diffusion encoding directions in Neonatal Diffusion Tensor Imaging using Tract-Based Spatial Statistical analysis
Effect of number of diffusion encoding directions in Neonatal Diffusion Tensor Imaging using Tract-Based Spatial Statistical analysis Open
Diffusion Tensor Imaging (DTI) has been used to study the developing brain in early childhood, infants and in utero studies. In infants, number of used diffusion encoding directions has traditionally been smaller in earlier studies down to…
View article: Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex
Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex Open
Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long‐lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. S…
View article: Infants sex affects neural responses to affective touch in early infancy
Infants sex affects neural responses to affective touch in early infancy Open
Social touch is closely related to the establishment and maintenance of social bonds in humans and the sensory brain circuit for gentle brushing is already active soon after birth. Brain development is known to be sexually dimorphic, but t…
View article: Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex
Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex Open
Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long-lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. S…
View article: Allometry in the corpus callosum in neonates: Sexual dimorphism
Allometry in the corpus callosum in neonates: Sexual dimorphism Open
The corpus callosum (CC) is the largest fiber tract in the human brain, allowing interhemispheric communication by connecting homologous areas of the two cerebral hemispheres. In adults, CC size shows a robust allometric relationship with …
View article: Sex-specific associations between maternal pregnancy-specific anxiety and newborn amygdalar volumes - preliminary findings from the FinnBrain Birth Cohort Study
Sex-specific associations between maternal pregnancy-specific anxiety and newborn amygdalar volumes - preliminary findings from the FinnBrain Birth Cohort Study Open
Previous literature links maternal pregnancy-specific anxiety (PSA) with later difficulties in child emotional and social cognition as well as memory, functions closely related to the amygdala and the hippocampus. Some evidence also sugges…
View article: Gender‐specific associations between the dimensions of alexithymia personality trait and dental anxiety in parents of the FinnBrain Birth Cohort Study
Gender‐specific associations between the dimensions of alexithymia personality trait and dental anxiety in parents of the FinnBrain Birth Cohort Study Open
We evaluated gender‐specific associations of two dimensions of dental anxiety (anticipatory and treatment‐related dental anxiety) with three dimensions of alexithymia: difficulty in identifying feelings, difficulty in describing feelings, …
View article: Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus Open
View article: Successful suppression of musical hallucinations with low-frequency rTMS of the left temporo-parietal junction: A case report
Successful suppression of musical hallucinations with low-frequency rTMS of the left temporo-parietal junction: A case report Open
View article: Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy
Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy Open
Maternal depressive symptoms during pregnancy are a significant risk factor for adverse developmental and health outcomes of the offspring. The molecular mechanisms mediating the long-term effects of this exposure are not well understood. …
View article: Prenatal Glucocorticoid-Exposed Infants Do Not Show an Age-Typical Fear Bias at 8 Months of Age – Preliminary Findings From the FinnBrain Birth Cohort Study
Prenatal Glucocorticoid-Exposed Infants Do Not Show an Age-Typical Fear Bias at 8 Months of Age – Preliminary Findings From the FinnBrain Birth Cohort Study Open
Synthetic glucocorticoids (sGC) are frequently administered to pregnant women at risk for preterm delivery to promote fetal lung maturation. Despite their undeniable beneficial effects in lung maturation, the impact of these hormones on de…
View article: Maternal Alexithymic Traits Are Related to Lower Maternal Sensitivity and Higher Hostility in Maternal Caregiving Behavior—The FinnBrain Birth Cohort Study
Maternal Alexithymic Traits Are Related to Lower Maternal Sensitivity and Higher Hostility in Maternal Caregiving Behavior—The FinnBrain Birth Cohort Study Open
Background: The quality of parental caregiving behavior with their child plays a key role in optimal mother–infant interaction and in supporting child adaptive development. Sensitive caregiving behavior, in turn, requires the ability to id…
View article: Neonatal amygdala volumes and the development of self-regulation from early infancy to toddlerhood.
Neonatal amygdala volumes and the development of self-regulation from early infancy to toddlerhood. Open
Objective: At the broadest level, self-regulation (SR) refers to a range of separate, but interrelated, processes (e.g., working memory, inhibition, and emotion regulation) central for the regulation of cognition, emotion, an…
View article: Maternal Pre-pregnancy BMI Associates With Neonate Brain Local Synchrony in the Left Superior Frontal Gyrus: a Pilot Study
Maternal Pre-pregnancy BMI Associates With Neonate Brain Local Synchrony in the Left Superior Frontal Gyrus: a Pilot Study Open
Introduction: Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prio…
View article: Association of Cumulative Paternal Early Life Stress With White Matter Maturation in Newborns
Association of Cumulative Paternal Early Life Stress With White Matter Maturation in Newborns Open
This cohort study found a statistically significant association between paternal ELS and offspring brain development. This finding may have far-reaching implications in pediatrics, as it suggests the possibility of a novel route of interge…
View article: Educational differences in prenatal anxiety and depressive symptoms and the role of childhood circumstances
Educational differences in prenatal anxiety and depressive symptoms and the role of childhood circumstances Open
View article: Sex‐specific association between infant caudate volumes and a polygenic risk score for major depressive disorder
Sex‐specific association between infant caudate volumes and a polygenic risk score for major depressive disorder Open
Polygenic risk scores for major depressive disorder (PRS‐MDD) have been identified in large genome‐wide association studies, and recent findings suggest that PRS‐MDD might interact with environmental risk factors to shape human limbic brai…