Noorhan Ghanem
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View article: Distinct characteristics and social determinants in adult T‐cell leukaemia/lymphoma patients at a tertiary cancer centre in Canada
Distinct characteristics and social determinants in adult T‐cell leukaemia/lymphoma patients at a tertiary cancer centre in Canada Open
Summary Adult T‐cell leukaemia/lymphoma (ATLL) is a rare, aggressive haematological malignancy linked to human T‐cell leukaemia virus type I (HTLV‐1) and associated with poor outcomes. Despite its higher prevalence in HTLV‐1‐endemic region…
View article: Therapeutic Targeting of the Pentose Phosphate Pathway in Colorectal Cancer Using 6‐Aminonicotinamide and 5‐Fluorouracil
Therapeutic Targeting of the Pentose Phosphate Pathway in Colorectal Cancer Using 6‐Aminonicotinamide and 5‐Fluorouracil Open
Colorectal cancer (CRC) is a significant global health concern with rising incidence and mortality rates. 5‐Fluorouracil (5‐FU) is the standard chemotherapy for CRC but is often constrained by resistance and toxicity, highlighting the need…
View article: The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities
The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities Open
Background: Tumorigenesis is associated with deregulation of nutritional requirements, intermediary metabolites production, and microenvironment interactions. Unlike their normal cell counterparts, tumor cells rely on aerobic…