Nora Bourbia
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ZFHX3 plays a role in pain and cautious-like behaviours in mice Open
A missense mutation in zinc finger homeobox-3 (ZFHX3) gene is known to alter circadian rhythms and metabolism. ZFHX3 is highly expressed in the central nucleus of amygdala and so we investigated whether female and male Zfhx3 Sci-/+ mice ha…
Polyethylene terephthalate (PET) micro- and nanoplastic particles affect the mitochondrial efficiency of human brain vascular pericytes without inducing oxidative stress Open
The objective of this investigation was to evaluate the influence of micro- and nanoplastic particles composed of polyethylene terephthalate (PET), a significant contributor to plastic pollution, on human brain vascular pericytes. Specific…
A missense mutation in zinc finger homeobox‐3 ( <span>ZFHX3</span> ) impedes growth and alters metabolism and hypothalamic gene expression in mice Open
A protein altering variant in the gene encoding zinc finger homeobox‐3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome‐wide association study. We investigated metabolic parameters in mice harboring a missense mutati…
In vitro study of ochratoxin A in the expression of genes associated with neuron survival and viability Open
Ochratoxin A (OTA) is a common mycotoxin and known contaminant of crops, foods and drinks. As OTA crosses the blood-brain barrier, this study investigated the role of OTA, as an environmental hazard, on neuronal survival and viability. The…
A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice Open
A protein altering variant in the gene encoding zinc finger homeobox-3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome-wide association study. We investigated metabolic parameters in mice harbouring a missense mutat…
View article: Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits Open
A noninvasive sleep screen uncovers a Vamp2 mouse mutation with synaptic deficits underlying substantial sleep disturbances.
Aberrant synaptic release underlies sleep/wake transition deficits in a mouse <i>Vamp2</i> mutant Open
Sleep-wake transitions are modulated through extensive subcortical networks although the precise roles of their individual components remain elusive. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mut…
Involvement of the Periaqueductal Gray in the Descending Antinociceptive Effect Induced by the Central Nucleus of Amygdala Open
Here we studied whether descending control of mechanical nociception by glutamate in the central nucleus of the amygdala (CeA) of healthy control animals is induced by amygdaloid NMDA receptors and relayed through the midbrain periaqueduct…