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View article: Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis
Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis Open
Epigenetic mechanisms regulate gene expression programs during neurogenesis, but the extent of epigenetic remodeling during human cortical development remains unknown. Here, we characterize the epigenetic landscape of the human developing …
View article: Epigenetic and metabolic regulation of developmental timing in neocortex evolution
Epigenetic and metabolic regulation of developmental timing in neocortex evolution Open
The human brain is characterized by impressive cognitive abilities. The neocortex is the seat of higher cognition, and neocortex expansion is a hallmark of human evolution. While developmental programs are similar in different species, the…
View article: Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution
Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution Open
As the seat of our cognition, the human neocortex is an object of immense fascination. Human neocortex expansion during evolution has been attributed to an increase in the proliferative capacity of neural progenitor cells during developmen…
View article: Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis
Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis Open
Summary Epigenetic mechanisms regulate gene expression programs during neurogenesis, but the extent of epigenetic remodelling during human cortical development remains unknown. Here, we characterize the epigenetic landscape of the human de…
View article: Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex
Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex Open
SUMMARY Neocortex expansion during evolution is linked to higher numbers of neurons thought to result from increased proliferative capacity and neurogenic potential of basal progenitor cells (BPs) during development. Here we show that EREG…