Nora Mattek
YOU?
Author Swipe
View article: Home-Based Digital Technologies to Support Aging-in-Place for Rural African American People With Alzheimer Disease and Their Care Partners: Protocol for a Mixed Methods Feasibility Study
Home-Based Digital Technologies to Support Aging-in-Place for Rural African American People With Alzheimer Disease and Their Care Partners: Protocol for a Mixed Methods Feasibility Study Open
Background Rural, low-income African American people have the highest Alzheimer disease and related dementia (ADRD) incidence and prevalence rates but have the least access to formal dementia care. To support individuals living with ADRD, …
View article: α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid
α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid Open
Introduction CSF α -klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF). Methods CSF α -klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to asses…
View article: Home-Based Digital Technologies to Support Aging-in-Place for Rural African American People With Alzheimer Disease and Their Care Partners: Protocol for a Mixed Methods Feasibility Study (Preprint)
Home-Based Digital Technologies to Support Aging-in-Place for Rural African American People With Alzheimer Disease and Their Care Partners: Protocol for a Mixed Methods Feasibility Study (Preprint) Open
BACKGROUND Rural, low-income African American people have the highest Alzheimer disease and related dementia (ADRD) incidence and prevalence rates but have the least access to formal dementia care. To support individuals living with ADRD,…
View article: Feasibility of Telephone‐Based Cognitive Assessments and Healthcare Utilization in US Medicare‐Enrolled Older Adults Following Emergency Department Discharge
Feasibility of Telephone‐Based Cognitive Assessments and Healthcare Utilization in US Medicare‐Enrolled Older Adults Following Emergency Department Discharge Open
Background Wider screening and assessment for Alzheimer's disease and other related dementias (ADRD) may increase access to supportive care, improve allocation of medical care, and foster the use of interventions that prevent or delay dise…
View article: Disrupted Sleep at Night is Associated with a Higher Level of Agitation Throughout the Week in People Living with Cognitive Decline
Disrupted Sleep at Night is Associated with a Higher Level of Agitation Throughout the Week in People Living with Cognitive Decline Open
Background Agitation is one of the most challenging behaviors exhibited by people with cognitive decline, causing distress in caregivers, earlier placement into long‐term care and faster disease progression. In order to better manage agita…
View article: Disrupted Sleep at Night Is Associated with a Higher Level of Agitation Throughout the Week in People Living with Cognitive Decline
Disrupted Sleep at Night Is Associated with a Higher Level of Agitation Throughout the Week in People Living with Cognitive Decline Open
Background Agitation is one of the most challenging behaviors exhibited by people with cognitive decline, causing distress in caregivers, earlier placement into long‐term care and faster disease progression. In order to better manage agita…
View article: DETECT‐AD ‐ Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease: Results of amyloid screening methodologies in a simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures
DETECT‐AD ‐ Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease: Results of amyloid screening methodologies in a simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures Open
Background With the advent of anti‐amyloid therapies, identifying those with underlying amyloid burdens and detecting subsequent clinical effects of this AD pathology is critical. The DETECT‐AD study (ClinicalTrials.gov, NCT05385913) is a …
View article: ADAPTATIONS AND OUTCOMES OF A WALKING AND REMINISCENCE BRAIN HEALTH INTERVENTION FOR CAREGIVERS
ADAPTATIONS AND OUTCOMES OF A WALKING AND REMINISCENCE BRAIN HEALTH INTERVENTION FOR CAREGIVERS Open
The SHARP-Caregiver (SHARP-CG) study evaluated the feasibility of adapting SHARP to family caregivers of care partners with mild cognitive impairment or early-stage dementia. SHARP-CG assigned 7 triads (n=21) to Group A or B. Triads had a …
View article: Comprehensive nutrient biomarker assessment in older adults at risk for dementia: Pre‐analytical and intra‐individual stability over 2‐4 years in the Nutrition and Brain Aging Study
Comprehensive nutrient biomarker assessment in older adults at risk for dementia: Pre‐analytical and intra‐individual stability over 2‐4 years in the Nutrition and Brain Aging Study Open
Background Nutrient biomarkers (NBs) may serve as more accurate and precise indicators of dietary intake, particularly in older adults who often have subtle episodic memory recall and digestive/microbiome issues that alter the nutritional …
View article: The African American Dementia and Aging Project: an Oregon-based longitudinal study
The African American Dementia and Aging Project: an Oregon-based longitudinal study Open
Introduction The vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience. Here we describe th…
View article: Ascertaining Out-of-Pocket Costs of Dementia Care: Feasibility Study of a Web-Based Weekly Survey
Ascertaining Out-of-Pocket Costs of Dementia Care: Feasibility Study of a Web-Based Weekly Survey Open
Background Caring for a family member living with dementia is costly. A major contributor to care demands, and therefore to the costs, are the behavioral symptoms of dementia. Here, we examine the feasibility of ascertaining costs related …
View article: Three Year Pre-analytical and Intra-individual Stability of Plasma Nutrient Biomarkers in Older Adults at Risk for Dementia: Effects of Sex, apoE Genotype and Cognition
Three Year Pre-analytical and Intra-individual Stability of Plasma Nutrient Biomarkers in Older Adults at Risk for Dementia: Effects of Sex, apoE Genotype and Cognition Open
Objectives: Nutrient biomarkers (NBs) are objective indicators of diet quality and health status reflecting the nourishing liquor readily available to support the metabolic needs of the brain. Prior to more significant investment and broad…
View article: The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study
The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study Open
Objectives The vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience. Here we describe the …
View article: Walking and Social Reminiscence in Gentrifying Neighborhoods: Feasibility and Impact on Cognitive, Physical, and Mental Health Among Older Black Adults in the SHARP Study
Walking and Social Reminiscence in Gentrifying Neighborhoods: Feasibility and Impact on Cognitive, Physical, and Mental Health Among Older Black Adults in the SHARP Study Open
Background and Objectives Two exploratory 6-month pilots of triadic walking with culturally celebratory social reminiscence in gentrifying neighborhoods tested feasibility and health impact among normal and mildly cognitively impaired (MCI…
View article: Normative data on the CERAD Word List in a robustly intact sample of older adults
Normative data on the CERAD Word List in a robustly intact sample of older adults Open
Background List learning and memory tests are frequently used to evaluate older adults for late life cognitive disorders, such as Alzheimer’s disease. The Word List subtest of the Consortium to Establish a Registry for Alzheimer’s Disease …
View article: Identifying change on the CERAD Word List with standardized regression‐based scores
Identifying change on the CERAD Word List with standardized regression‐based scores Open
Background List learning and memory tests are frequently used to evaluate older adults for Mild Cognitive Impairment and Alzheimer’s disease. One such test, the Word List subtest of the Consortium to Establish a Registry for Alzheimer’s Di…
View article: DETECT‐AD (Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease): A simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures
DETECT‐AD (Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease): A simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures Open
Background Early detection and precise monitoring of cognitive and functional decline in persons with Alzheimer’s Disease (AD) in clinical trials is a high priority. Unfortunately, early detection and monitoring of the subtle and slow chan…
View article: ONLINE COGNITIVE MONITORING IN A SIMULATED ANTI-AMYLOID TRIAL: ADHERENCE AND COGNITIVE CHANGE
ONLINE COGNITIVE MONITORING IN A SIMULATED ANTI-AMYLOID TRIAL: ADHERENCE AND COGNITIVE CHANGE Open
Remote assessment of cognitive function is increasingly of interest for monitoring cognitive decline. Additional advantages of remote monitoring are more frequent assessments and the examination of change over time, which may yield more se…
View article: DETECT‐AD (Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease): A simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures
DETECT‐AD (Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease): A simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures Open
Background Early detection and precise monitoring of cognitive and functional decline in persons with Alzheimer’s Disease (AD) in clinical trials is a high priority. Unfortunately, early detection and monitoring of the subtle and slow chan…
View article: ‘There’s no straight line…’ a consumer-informed intervention for FTD family care partners: the STELLA-FTD pilot study
‘There’s no straight line…’ a consumer-informed intervention for FTD family care partners: the STELLA-FTD pilot study Open
The revised STELLA-FTD intervention was found to be feasible and acceptable, and has potential to improve care partner burden for families living with FTD. Providing the intervention via telehealth maximized access and engaged rehab…
View article: Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology
Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology Open
Background Outcome measures available for use in Alzheimer’s disease (AD) clinical trials are limited in ability to detect gradual changes. Measures of everyday function and cognition assessed unobtrusively at home using embedded sensing a…
View article: Caregiving in Older Adults; Experiences and Attitudes toward Smart Technologies
Caregiving in Older Adults; Experiences and Attitudes toward Smart Technologies Open
(1) Background: The development of assistive technologies has become a key solution to reduce caregiver burden. The objective of this study was to survey caregivers on perceptions and beliefs about the future of modern technology in caregi…
View article: Predicting Major Decline in Older Adults: The Role of Time Spent Out of Home
Predicting Major Decline in Older Adults: The Role of Time Spent Out of Home Open
Background For older adults in community settings, predicting undesired outcomes (needing higher levels of care or death) is important for advancing preventative care and achieving successful aging. We examined whether a combination of bas…
View article: WHAT DO 'BEHAVIORS" COST? UNDERSTANDING COSTS IN DEMENTIA CARE PARTNER-BASED RESEARCH
WHAT DO 'BEHAVIORS" COST? UNDERSTANDING COSTS IN DEMENTIA CARE PARTNER-BASED RESEARCH Open
The out-of-pocket costs to care for individuals living with dementia are high, and is exacerbated by the expense of managing behavioral and psychological symptoms of dementia (BPSD) (e.g., depression, irritability). STELLA (Support via TEc…
View article: Mood and activity changes during the COVID-19 pandemic in rural and urban Veterans and their cohabitants
Mood and activity changes during the COVID-19 pandemic in rural and urban Veterans and their cohabitants Open
The COVID-19 pandemic associated health precautions, while necessary to curb acute health risks, have created a unique situation that places vulnerable populations at increased risk of low mood.
View article: The Survey for Memory, Attention, and Reaction Time (SMART): Preliminary normative online panel data and user attitudes for a brief web-based cognitive performance measure
The Survey for Memory, Attention, and Reaction Time (SMART): Preliminary normative online panel data and user attitudes for a brief web-based cognitive performance measure Open
ObjectiveThe Survey for Memory, Attention, and Reaction Time (SMART) was recently introduced as a brief (Method A sample of 1,050 community-dwelling adults (M age =59.5 (15.2), M education = 16.5 (2.1), 67.1% femal…
View article: Control Matters in Elder Care Technology: Evidence and Direction for Designing It In
Control Matters in Elder Care Technology: Evidence and Direction for Designing It In Open
Studies find that older adults want control over how technologies are used in their care, but how it can be operationalized through design remains to be clarified. We present findings from a large survey (n=825) of a well-characterized U.S…
View article: Association Between Mild Cognitive Impairment and Seasonal Rest-Activity Patterns of Older Adults
Association Between Mild Cognitive Impairment and Seasonal Rest-Activity Patterns of Older Adults Open
Seasonal variation in rest-activity patterns has been observed in healthy adult populations. This study examined seasonal variation in total time spent overnight in the bedroom by cognitively intact older adults and older adults with mild …
View article: Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function
Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function Open
Background: α-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) a…
View article: Preferences of NIA Alzheimer's Disease Research Center participants regarding remote assessment during the COVID‐19 pandemic
Preferences of NIA Alzheimer's Disease Research Center participants regarding remote assessment during the COVID‐19 pandemic Open
Introduction During the COVID‐19 pandemic, in‐person research study visits were moved to an online format using a variety of communication platforms (e.g., Webex and Zoom). Increased technology use among older adults allowed for greater in…