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View article: Layer by layer nanocoating of chlorhexidine-loaded micelles on polymethyl methacrylate denture base
Layer by layer nanocoating of chlorhexidine-loaded micelles on polymethyl methacrylate denture base Open
The development of antimicrobial denture bases using this coating method has shown promising results. The optimized coating effectively prolonged CHX release, inhibited fungal growth, and maintained biocompatibility.
View article: In vitro and in vivo evaluation of immortalized hepatocyte encapsulated click-microbeads with RGD peptide for treatment of liver failure in male rats
In vitro and in vivo evaluation of immortalized hepatocyte encapsulated click-microbeads with RGD peptide for treatment of liver failure in male rats Open
Cell encapsulation in biocompatible microbeads offers a promising strategy for cell-based therapy in acute liver failure (ALF). This study evaluates the use of immortalized hepatocyte cells (imHCs) encapsulated in click-arginyl glycyl aspa…
View article: Superparamagnetic Micelles for the Magnetic Hyperthermia Against Glioblastoma: A Multiphysics Approach for Personalized Treatment Planning
Superparamagnetic Micelles for the Magnetic Hyperthermia Against Glioblastoma: A Multiphysics Approach for Personalized Treatment Planning Open
The treatment of diffuse, high-grade gliomas, the most aggressive form of primary brain tumors, poses significant therapeutic challenges. Recurrent high-grade gliomas are associated with a median overall survival of less than one year; the…
View article: In vitro and in vivo evaluation of the layer-by-layer vancomycin with poly(ε-caprolactone) nanosphere-coated Schanz pins for prolonged release
In vitro and in vivo evaluation of the layer-by-layer vancomycin with poly(ε-caprolactone) nanosphere-coated Schanz pins for prolonged release Open
In this research, the effect of layer-by-layer (spray and dip) coating followed by annealing of vancomycin (VCM) and poly(ε-caprolactone) nanospheres (PCLnp) on Schanz pins for prolonged antibacterial activity was investigated. Nanospheres…
View article: Encapsulation of Cyclosporine A-Loaded PLGA Nanospheres in Alginate Microbeads for Anti-Inflammatory Application
Encapsulation of Cyclosporine A-Loaded PLGA Nanospheres in Alginate Microbeads for Anti-Inflammatory Application Open
The controlled release of cyclosporine A (CsA) microencapsulated in alginate microbeads is a novel drug delivery system for the treatment of inflammatory diseases. In this study, CsA-loaded nanospheres encapsulated in alginate microbeads w…
View article: Antibiotic impregnation and nanocoating of external ventricular drainage catheters for antibacterial applications: Evaluation of <i>in vitro</i> studies and molecular docking
Antibiotic impregnation and nanocoating of external ventricular drainage catheters for antibacterial applications: Evaluation of <i>in vitro</i> studies and molecular docking Open
The most suitable method to treat hydrocephalus disease is to insert a shunt catheter that drains the cerebral spinal fluid (CSF); however, shunt implantation is often associated with various bacterial infections. In this study, antibiotic…
View article: Antibacterial and biocompatibility studies of triple antibiotics-impregnated external ventricular drainage: In vitro and in vivo evaluation
Antibacterial and biocompatibility studies of triple antibiotics-impregnated external ventricular drainage: In vitro and in vivo evaluation Open
Hydrocephalus is a neurological disease caused by an unusually high level of cerebrospinal fluid (CSF), which can be relieved by external ventricular drainage (EVD) insertion. However, the infection can lead to complications during the use…
View article: Biomimetic Targeted Theranostic Nanoparticles for Breast Cancer Treatment
Biomimetic Targeted Theranostic Nanoparticles for Breast Cancer Treatment Open
The development of biomimetic drug delivery systems for biomedical applications has attracted significant research attention. As the use of cell membrane as a surface coating has shown to be a promising platform for several disease treatme…
View article: The Cholesterol-Modulating Effect of the New Herbal Medicinal Recipe from Yellow Vine (Coscinium fenestratum (Goetgh.)), Ginger (Zingiber officinale Roscoe.), and Safflower (Carthamus tinctorius L.) on Suppressing PCSK9 Expression to Upregulate LDLR Expression in HepG2 Cells
The Cholesterol-Modulating Effect of the New Herbal Medicinal Recipe from Yellow Vine (Coscinium fenestratum (Goetgh.)), Ginger (Zingiber officinale Roscoe.), and Safflower (Carthamus tinctorius L.) on Suppressing PCSK9 Expression to Upregulate LDLR Expression in HepG2 Cells Open
PCSK9 is a promising target for developing novel cholesterol-lowering drugs. We developed a recipe that combined molecular docking, GC-MS/MS, and real-time PCR to identify potential PCSK9 inhibitors for herb ratio determination. Three herb…
View article: Preparation and Characterization of MUC-30-Loaded Polymeric Micelles against MCF-7 Cell Lines Using Molecular Docking Methods and In Vitro Study
Preparation and Characterization of MUC-30-Loaded Polymeric Micelles against MCF-7 Cell Lines Using Molecular Docking Methods and In Vitro Study Open
MUC-30 is a hydrophobic compound which is active against the MCF-7 cancer cell line. In this study, MUC-30 was loaded in polymeric micelles to improve the water solubility and release rate. For prolonged MUC-30 release, MUC-30 was encapsul…
View article: Characterization on the reduction of burst release via biodegradable polymers from chlorhexidine-release on coated Foley urinary catheter by chlorhexidine-loaded micelles
Characterization on the reduction of burst release via biodegradable polymers from chlorhexidine-release on coated Foley urinary catheter by chlorhexidine-loaded micelles Open
In this work, chlorhexidine-loaded block copolymer was fabricated into micelles (CHX-micelles) and was then coated on foley urinary catheter by dip technique. The number cycles of coating were alternated the bilayers between (CHX-micelles)…
View article: Imidazole-modified deferasirox encapsulated polymeric micelles as pH-responsive iron-chelating nanocarrier for cancer chemotherapy
Imidazole-modified deferasirox encapsulated polymeric micelles as pH-responsive iron-chelating nanocarrier for cancer chemotherapy Open
Modified deferasirox encapsulated polymeric micelles demonstrate pH-responsive and ON–OFF release behavior to deplete the iron level in cancer cells. The cellular iron deficiency is a novel strategy for cancer treatment.
View article: Preparation and Characterizations of RSPP050-Loaded Polymeric Micelles Using Poly(ethylene glycol)-<i>b</i>-Poly(ε-caprolactone) and Poly(ethylene glycol)-<i>b</i>-Poly(D,L-lactide)
Preparation and Characterizations of RSPP050-Loaded Polymeric Micelles Using Poly(ethylene glycol)-<i>b</i>-Poly(ε-caprolactone) and Poly(ethylene glycol)-<i>b</i>-Poly(D,L-lactide) Open
RSPP050 (AG50) is one of the semi-synthetic andrographolide that is isolated from Andrographis paniculata NEES (Acanthaceae). The anti-proliferation effects of AG50 against cholangiocarcinoma (HuCCT1) were displayed high cytotoxicity. Unfo…