Norbert Hosten
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View article: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…
View article: Association of layer-specific knee cartilage T2-relaxation measurements with age, sex and cartilage morphology at 1.5-T MRI
Association of layer-specific knee cartilage T2-relaxation measurements with age, sex and cartilage morphology at 1.5-T MRI Open
Objective This study aimed to establish normal knee cartilage T2-values at 1.5-Tesla, assess the influence of age and sex on T2-values, and compares T2-times between subjects with and without morphological cartilage changes. Materials and …
View article: Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO)
Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO) Open
Little is known about the relation between traffic noise exposure, an established environmental risk factor for cardiovascular disease, and early obesity-related risk markers such as adipose tissue (AT) and hepatic fat. Therefore, we aimed…
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
View article: Baseline MRI examination in the NAKO Health Study—findings on feasibility, participation and dropout rates, comfort, and image quality
Baseline MRI examination in the NAKO Health Study—findings on feasibility, participation and dropout rates, comfort, and image quality Open
Whole-body MRI was successfully implemented in the NAKO baseline examination and was associated with high patient comfort and very good image quality. The imaging biomarkers of the brain confirmed previously observed differences based on a…
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globu…
View article: Changes in MRI Workflow of Multiple Sclerosis after Introduction of an AI-Software: A Qualitative Study
Changes in MRI Workflow of Multiple Sclerosis after Introduction of an AI-Software: A Qualitative Study Open
The purpose of this study was to explore the effects of the integration of machine learning into daily radiological diagnostics, using the example of the machine learning software mdbrain® (Mediaire GmbH, Germany) in the diagnostic MRI wor…
View article: Is there a fast track (“Darmstrasse”) for fluids in the small intestine? Evidence from magnetic resonance imaging
Is there a fast track (“Darmstrasse”) for fluids in the small intestine? Evidence from magnetic resonance imaging Open
The transit and distribution pattern of fluids in the small intestine is a key parameter for the dissolution and absorption of drugs. Although some information is known about the small intestinal water content after administration of fluid…
View article: Delegation of the primary responsibility for MRI informed consent to technical assistants—findings from the NAKO health study
Delegation of the primary responsibility for MRI informed consent to technical assistants—findings from the NAKO health study Open
View article: Doctor’s Orders—Why Radiologists Should Consider Adjusting Commercial Machine Learning Applications in Chest Radiography to Fit Their Specific Needs
Doctor’s Orders—Why Radiologists Should Consider Adjusting Commercial Machine Learning Applications in Chest Radiography to Fit Their Specific Needs Open
This retrospective study evaluated a commercial deep learning (DL) software for chest radiographs and explored its performance in different scenarios. A total of 477 patients (284 male, 193 female, mean age 61.4 (44.7–78.1) years) were inc…
View article: Automated image quality assessment for selecting among multiple magnetic resonance image acquisitions in the German National Cohort study
Automated image quality assessment for selecting among multiple magnetic resonance image acquisitions in the German National Cohort study Open
View article: The Effect of Cooling Fluid Composition on Ablation Size in Hepatic Laser Ablation: A Comparative Study in an Ex Vivo Bovine Setting
The Effect of Cooling Fluid Composition on Ablation Size in Hepatic Laser Ablation: A Comparative Study in an Ex Vivo Bovine Setting Open
Purpose: Hyperthermic ablation is a minimally invasive mode of tumour therapy which serves as a viable alternative to surgical intervention. However, one of the major drawbacks, besides the heat sink effect and the risk of damaging adjacen…
View article: Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort
Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort Open
This research addresses the assessment of adipose tissue (AT) and spatial distribution of visceral (VAT) and subcutaneous fat (SAT) in the trunk from standardized magnetic resonance imaging at 3 T, thereby demonstrating the feasibility of …
View article: Quantitative Diffusion-Weighted MRI of Neuroblastoma
Quantitative Diffusion-Weighted MRI of Neuroblastoma Open
Neuroblastoma is the most common extracranial, malignant, solid tumor found in children. In more than one-third of cases, the tumor is in an advanced stage, with limited resectability. The treatment options include resection, with or witho…
View article: Trauma to the Eye: Diffusion Restriction on MRI as a Surrogate Marker for Blindness
Trauma to the Eye: Diffusion Restriction on MRI as a Surrogate Marker for Blindness Open
Traumatic optic nerve injury may lead to almost instantaneous blindness. We describe a case of sight loss after a perforating injury to the eye. The case is unusual in that the patient remained conscious and the trauma to the eye was isola…
View article: Spacer-Supported Thermal Ablation to Prevent Carbonisation and Improve Ablation Size: A Proof of Concept Study
Spacer-Supported Thermal Ablation to Prevent Carbonisation and Improve Ablation Size: A Proof of Concept Study Open
Thermal ablation offers a minimally invasive alternative in the treatment of hepatic tumours. Several types of ablation are utilised with different methods and indications. However, to this day, ablation size remains limited due to the for…
View article: Do brachycephaly and nose size predict the severity of obstructive sleep apnea (<scp>OSA</scp>)? A sample‐based geometric morphometric analysis of craniofacial variation in relation to <scp>OSA</scp> syndrome and the role of confounding factors
Do brachycephaly and nose size predict the severity of obstructive sleep apnea (<span>OSA</span>)? A sample‐based geometric morphometric analysis of craniofacial variation in relation to <span>OSA</span> syndrome and the role of confounding factors Open
Summary Obstructive sleep apnea is a common disorder that leads to sleep fragmentation and is potentially bidirectionally related to a variety of comorbidities, including an increased risk of heart failure and stroke. It is often considere…
View article: Dank an die Gutachter
Dank an die Gutachter Open
View article: Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI
Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI Open
Cerebral white matter hyperintensities on MRI are markers of cerebral small vessel disease, a major risk factor for dementia and stroke. Despite the successful identification of multiple genetic variants associated with this highly heritab…
View article: Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer’s Disease in Predominantly Middle-Aged Adults
Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer’s Disease in Predominantly Middle-Aged Adults Open
Background: Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer’s disease pathogenesis, and further evidence suggests inflammation can be a moderator of this association. However, most research to date has been …
View article: Cohort Profile Update: The Study of Health in Pomerania (SHIP)
Cohort Profile Update: The Study of Health in Pomerania (SHIP) Open
... The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-START (recruited between 1997 and 2001) and SHIP-TREND (recruited between 2008 to 2012), which were established to examine the health and disease status…
View article: Clinical and neurophysiological patterns of impairments to emotion attention and empathy in multiple sclerosis
Clinical and neurophysiological patterns of impairments to emotion attention and empathy in multiple sclerosis Open
Patients suffering from multiple sclerosis experience various cognitive and affective impairments, resulting in a negative impact on social behavior and personal independence to differing degrees. According to these often clinically subtle…
View article: Circulating Metabolome and White Matter Hyperintensities in Women and Men
Circulating Metabolome and White Matter Hyperintensities in Women and Men Open
Background: White matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no large-scale studi…
View article: Greater male than female variability in regional brain structure across the lifespan
Greater male than female variability in regional brain structure across the lifespan Open
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents…
View article: SHIP-MR and Radiology: 12 Years of Whole-Body Magnetic Resonance Imaging in a Single Center
SHIP-MR and Radiology: 12 Years of Whole-Body Magnetic Resonance Imaging in a Single Center Open
The Study of Health in Pomerania (SHIP), a population-based study from a rural state in northeastern Germany with a relatively poor life expectancy, supplemented its comprehensive examination program in 2008 with whole-body MR imaging at 1…
View article: On Efficient Segmentation of Parapharyngeal Fat Pads From Population-based MRIs: An Obstructive Sleep Apnea Application
On Efficient Segmentation of Parapharyngeal Fat Pads From Population-based MRIs: An Obstructive Sleep Apnea Application Open
The main purpose of our project was to automatically delineate parapharyngeal fat pads from magnetic resonance imaging (MR) data, since these structures are considered important for diagnosis of obstructive sleep apnea syndrome (OSAS). Her…
View article: Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany
Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany Open
This study found significant associations between OSA and brain WMHs, indicating a novel, potentially treatable WMH pathomechanism.
View article: Retrospective Cohort Study of Frequency and Patterns of Orbital Injuries on Whole-Body CT with Maxillofacial Multi-Slice CT
Retrospective Cohort Study of Frequency and Patterns of Orbital Injuries on Whole-Body CT with Maxillofacial Multi-Slice CT Open
Background: High-impact trauma frequently leads to injuries of the orbit, but literature focusing on the viscerocranium rather than the neurocranium is underrepresented. Methods: Retrospective cohort study (2006–2014) at an urban level 1 t…
View article: Correction: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders
Correction: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders Open