Norbert Kathmann
YOU?
Author Swipe
View article: Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium
Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is a chronic condition in which impaired inhibitory control and excessive error monitoring may contribute to the maintenance of obsessions and compulsions. This mega-analysis investigates neura…
View article: Working memory load-dependent modulation of neural activity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder
Working memory load-dependent modulation of neural activity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder Open
Cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD). However, CBT does not lead to a satisfying symptom reduction in a considerable number of patients with OCD. The identification of variabl…
View article: Pavlovian fear reversal learning predicts outcome of exposure-based cognitive behavioral therapy for adult obsessive-compulsive disorder
Pavlovian fear reversal learning predicts outcome of exposure-based cognitive behavioral therapy for adult obsessive-compulsive disorder Open
Extinction of conditioned fear responses is assumed to relate to beneficial effects of exposure-based treatment, but few studies investigated the role of fear conditioning for exposure techniques in clinical settings. Specifically, no stud…
View article: Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium
Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during execut…
View article: Towards Just-In-Time Adaptive Interventions - Moment-to-moment Prediction of Negative Affect in Internalizing Disorders using Digital Phenotyping
Towards Just-In-Time Adaptive Interventions - Moment-to-moment Prediction of Negative Affect in Internalizing Disorders using Digital Phenotyping Open
Negative affect (NA)—encompassing heightened states of sadness, anxiety, and guilt—is a key symptom across a spectrum of internalizing disorders. Recent advancements in digital phenotyping (DP) and machine learning (ML) have raised hopes o…
View article: Differential Gaze Disengagement from Friendly and Disdainful Facial Expressions Predicts Reliable Increase of Depressive Symptoms Following Euthymia: Preliminary Evidence from an Eye-Tracking Study at 6-Month Follow-up
Differential Gaze Disengagement from Friendly and Disdainful Facial Expressions Predicts Reliable Increase of Depressive Symptoms Following Euthymia: Preliminary Evidence from an Eye-Tracking Study at 6-Month Follow-up Open
Background Attentional biases to emotional information are assumed to play a crucial role in the onset and maintenance of depression. Moreover, recent studies show that biases may remain present in previously affected individuals during no…
View article: Design and methods of the research unit 5187 PREACT (towards precision psychotherapy for non-respondent patients: from signatures to predictions to clinical utility) – a study protocol for a multicentre observational study in outpatient clinics
Design and methods of the research unit 5187 PREACT (towards precision psychotherapy for non-respondent patients: from signatures to predictions to clinical utility) – a study protocol for a multicentre observational study in outpatient clinics Open
Introduction Cognitive–behavioural therapy (CBT) works—but not equally well for all patients. Less than 50% of patients with internalising disorders achieve clinically meaningful improvement, with negative consequences for patients and hea…
View article: Heart rate and heart rate variability in obsessive-compulsive disorder: Evidence from patients and unaffected first-degree relatives
Heart rate and heart rate variability in obsessive-compulsive disorder: Evidence from patients and unaffected first-degree relatives Open
View article: Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group Open
View article: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group Open
View article: Measurement Invariance Widely Holds for the Yale-Brown Obsessive Compulsive Scale
Measurement Invariance Widely Holds for the Yale-Brown Obsessive Compulsive Scale Open
The clinician-rated Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is a widely used assessment tool for obsessive-compulsive disorder (OCD). However, the measurement invariance (MI) properties of the Y-BOCS, a prerequisite for group or tim…
View article: Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response
Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response Open
View article: White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group
White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group Open
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies…
View article: Correction: Don’t worry, it won’t be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation
Correction: Don’t worry, it won’t be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation Open
View article: Don’t worry, it won’t be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation
Don’t worry, it won’t be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation Open
View article: Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response
Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response Open
Obsessive-compulsive disorder (OCD) is a mental disorder affecting 2-3% of the general population. The dynamic nature of epigenetics provides a unique opportunity to find biomarkers of OCD symptoms, clinical progression, and treatment resp…
View article: Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response
Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response Open
Obsessive-compulsive disorder (OCD) is a mental disorder affecting 2-3% of the general population. The dynamic nature of epigenetics provides a unique opportunity to find biomarkers of OCD symptoms, clinical progression, and treatment resp…
View article: Affective evaluation of errors and neural error processing in obsessive-compulsive disorder
Affective evaluation of errors and neural error processing in obsessive-compulsive disorder Open
Even though overactive error monitoring, indexed by enhanced amplitudes of the error-related negativity (ERN), is a potential biomarker for obsessive-compulsive disorder (OCD), the mechanisms underlying clinical variations in ERN amplitude…
View article: Effects of a three-week executive control training on adaptation to task difficulty and emotional interference
Effects of a three-week executive control training on adaptation to task difficulty and emotional interference Open
Intact executive functions are characterized by flexible adaptation to task requirements, while these effects are reduced in internalizing disorders. Furthermore, as executive functions play an important role in emotion regulation, deficit…
View article: Don't worry, it won't be fine. Contributions of anxious apprehension and anxious arousal to startle responses and event-related potentials in threat anticipation
Don't worry, it won't be fine. Contributions of anxious apprehension and anxious arousal to startle responses and event-related potentials in threat anticipation Open
A widely shared framework suggests that anxiety maps onto two dimensions: Anxious apprehension and anxious arousal. Previous research linked individual differences in these dimensions to differential neural response patterns in neuropsycho…
View article: Associations of neural error‐processing with symptoms and traits in a dimensional sample recruited across the obsessive–compulsive spectrum
Associations of neural error‐processing with symptoms and traits in a dimensional sample recruited across the obsessive–compulsive spectrum Open
The error‐related negativity (ERN), a neural response to errors, has been associated with several forms of psychopathology and assumed to represent a neural risk marker for obsessive–compulsive disorder (OCD) and anxiety disorders. Yet, it…
View article: Early hypervigilance and later avoidance: Event-related potentials track the processing of threatening stimuli in anxiety
Early hypervigilance and later avoidance: Event-related potentials track the processing of threatening stimuli in anxiety Open
View article: The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder Open
View article: Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology
Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology Open
These findings suggest a moderating role of maternal depressive symptoms during pregnancy on the association of early life stress with inflammation and thus highlight the importance of the timely assessment of both CM exposure and depressi…
View article: Measurement Invariance Widely Holds for the Yale-Brown Obsessive Compulsive Scale
Measurement Invariance Widely Holds for the Yale-Brown Obsessive Compulsive Scale Open
View article: Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder
Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder Open
View article: Supplementary Material for: Effectiveness of Individual Cognitive-Behavioral Therapy and Predictors of Outcome in Adult Patients with Obsessive-Compulsive Disorder
Supplementary Material for: Effectiveness of Individual Cognitive-Behavioral Therapy and Predictors of Outcome in Adult Patients with Obsessive-Compulsive Disorder Open
Introduction: Cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) has proven its efficacy in randomized controlled trials (RCTs). Objective: To test generalizability to routine care settin…
View article: Error-related activity of the sensorimotor network contributes to the prediction of response to cognitive-behavioral therapy in obsessive–compulsive disorder
Error-related activity of the sensorimotor network contributes to the prediction of response to cognitive-behavioral therapy in obsessive–compulsive disorder Open
View article: Spatial working memory performance in people with obsessive–compulsive disorder, their unaffected first-degree relatives and healthy controls
Spatial working memory performance in people with obsessive–compulsive disorder, their unaffected first-degree relatives and healthy controls Open
Summary Studies have shown that people with obsessive–compulsive disorder (OCD) have impairments in spatial working memory (SWM) performance. However, it remains unclear whether this deficit represents a cognitive endophenotype preceding s…
View article: Cognitive control is quickly adapted to actual task requirements despite misleading context cues—Evidence from the N2, CRN, and ERN
Cognitive control is quickly adapted to actual task requirements despite misleading context cues—Evidence from the N2, CRN, and ERN Open
Cognitive control is flexibly adapted to task requirements in healthy individuals. Medio‐frontal negativities in the event‐related potential of the electroencephalogram can serve as indicators of cognitive control. With increasing conflict…