Norhafizah Mohtarrudin
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View article: Effect of Food Colorants Supplementation on Reactive Oxygen Species, Antioxidant Vitamins Level and DNA Damage
Effect of Food Colorants Supplementation on Reactive Oxygen Species, Antioxidant Vitamins Level and DNA Damage Open
There are various undesirable products generated from endogenous aerobic metabolism such as reactive oxygen species (ROS). Physiological and biochemical lesions are caused by ROS and which give rise to oxidative damages towards DNA, protei…
View article: In-vivo study of synthetic and natural food colors effect on biochemical and immunity parameters
In-vivo study of synthetic and natural food colors effect on biochemical and immunity parameters Open
Incorporation of the coloring agent, tartrazine and curcumin affects healthy physiological system leading to changes in hematology, biochemistry and enzymatic activity. Consequences of oral administration of tartrazine and curcumin were ex…
View article: In-vivo study of synthetic and natural food colors effect on biochemical and immunity parameters
In-vivo study of synthetic and natural food colors effect on biochemical and immunity parameters Open
Incorporation of the coloring agent, tartrazine and curcumin affects healthy physiological system leading to changes in hematology, biochemistry and enzymatic activity. Consequences of oral administration of tartrazine and curcumin were ex…
View article: Recommendations for High-Stakes Examinations for Public Malaysian Medical Faculties during the COVID-19 Pandemic
Recommendations for High-Stakes Examinations for Public Malaysian Medical Faculties during the COVID-19 Pandemic Open
The COVID-19 pandemic forced the Deans’ Council of Public Malaysian Medical Faculties to tackle the issue of examinations in the face of movement control orders (MCO). A task force decided that final professional examination is necessary a…
View article: Fatal non-traumatic fat embolism
Fatal non-traumatic fat embolism Open
Non-traumatic fat embolism (NTFE) is infrequently encountered in the clinical setting. The incidence of clinically detected fat embolism is less than 1%. It is diagnosed based on the evidence of fat emboli occluding the vessel lumen in a p…
View article: Safety evaluation of orally-administered methanol extract of Muntingia calabura Linn. leaves: A sub-chronic toxicity study in Sprague Dawley rats.
Safety evaluation of orally-administered methanol extract of Muntingia calabura Linn. leaves: A sub-chronic toxicity study in Sprague Dawley rats. Open
Muntingia calabura (M. calabura), locally known as "kerukup siam" or "buah ceri" belongs to the family Muntingiaceae and has been scientifically demonstrated to exert various pharmacological activities. The objectives of the current study …
View article: Skin Blood Flow Response Signal Using Time and Frequency Domain Features for Pressure Ulcer Evaluation
Skin Blood Flow Response Signal Using Time and Frequency Domain Features for Pressure Ulcer Evaluation Open
Pressure Ulcer (PU) is an area of the skin in which cutaneous tissue is compromised and there is progressive damage on the underlying tissue caused by blood flow obstruction due to prolonged external direct pressure. Research has shown tha…
View article: Effect of the miR‑96‑5p inhibitor and mimic on the migration and invasion of the SW480‑7 colorectal cancer cell line
Effect of the miR‑96‑5p inhibitor and mimic on the migration and invasion of the SW480‑7 colorectal cancer cell line Open
The objectives of the present study were to identify the aberrant expression of microRNA (miRNA) in colorectal carcinoma (CRC) tissues from published miRNA profiling studies and to investigate the effects of the identified miRNA inhibitor …
View article: Issue Information
Issue Information Open
TK"), who passed away on 20 Feb 2019 at the age of 88, was a pillar of the wound healing community.His role as a trauma surgeon and his curiosity as an investigator emerged over 5 decades ago.He became Director of the Wound Healing Laborat…
View article: SUB-ACUTE ORAL TOXICITY PROFILING OF THE METHANOLIC LEAF EXTRACT OF CLINACANTHUS NUTANS IN MALE AND FEMALE ICR MICE
SUB-ACUTE ORAL TOXICITY PROFILING OF THE METHANOLIC LEAF EXTRACT OF CLINACANTHUS NUTANS IN MALE AND FEMALE ICR MICE Open
Objective: This study aims to investigate the sub-acute oral toxicity of a methanolic leaf extract of Clinacanthus nutans (MECN) in male and female mice.Methods: The study used three groups of male and female mice, the crude MECN was disso…
View article: Annonacin Suppresses Tumor Promoting Stage in Two Stage Mouse Skin Tumorigenesis via Modulation of Multiple Cancer Signaling Pathways
Annonacin Suppresses Tumor Promoting Stage in Two Stage Mouse Skin Tumorigenesis via Modulation of Multiple Cancer Signaling Pathways Open
Annonacin, an annonaceous acetogenin isolated from Annona muricata has been reported to be strongly cytotoxic against various cell lines, in vitro. Nevertheless, its effect against in vivo tumor promoting activity has not been reported yet…
View article: Association between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer
Association between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer Open
This report from Malaysia shows the relationship of IL-17A197AA genotype with susceptibility to CRC.
View article: Vascular endothelial growth factor expression in renal cell carcinoma
Vascular endothelial growth factor expression in renal cell carcinoma Open
Introduction: Renal cell carcinoma (RCC) is the most common renal malignancies. In advanced stage, it is highly resistant to systemic therapies. RCC is a highly vascular tumour and angiogenesis pathway has been postulated in its carcinogen…
View article: Inhibition of cell migration and invasion by miR‑29a‑3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression
Inhibition of cell migration and invasion by miR‑29a‑3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression Open
The objective of this study was to determine the effect of miR‑29a‑3p inhibitor on the migration and invasion of colorectal cancer cell lines (CRC) and the underlying molecular mechanisms. miR‑29a‑3p was detected using reverse transcriptio…
View article: Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity
Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity Open
View article: Semipurified Ethyl Acetate Partition of Methanolic Extract of <i>Melastoma malabathricum</i> Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant‐Antisecretory‐Anti‐Inflammatory Action and Synergistic Action of Several Flavonoid‐Based Compounds
Semipurified Ethyl Acetate Partition of Methanolic Extract of <i>Melastoma malabathricum</i> Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant‐Antisecretory‐Anti‐Inflammatory Action and Synergistic Action of Several Flavonoid‐Based Compounds Open
Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl ac…
View article: Saffron extract and crocin reduced biomarkers associated with obesity in rats fed a high-fat diet
Saffron extract and crocin reduced biomarkers associated with obesity in rats fed a high-fat diet Open
Introduction: This study aimed to investigate the effect of saffron extract and crocin on blood biomarkers associated with obesity using the rat model. Methods: Obesity was induced by feeding a high-fat diet to 42 male Sprague-Dawley rats …
View article: Anticarcinogenic activity of <i>Muntingia calabura</i> leaves methanol extract against the azoxymethane-induced colon cancer in rats involved modulation of the colonic antioxidant system partly by flavonoids
Anticarcinogenic activity of <i>Muntingia calabura</i> leaves methanol extract against the azoxymethane-induced colon cancer in rats involved modulation of the colonic antioxidant system partly by flavonoids Open
Muntingia calabura leaves exert anticancer effect against AOM-induced colon cancer possibly via the action of flavonoids on the colon tissue antioxidant activity.
View article: One stop centre staging by contrast-enhanced 18F-FDG PET/CT in preoperative assessment of ovarian cancer and proposed diagnostic imaging algorithm: a single centre experience in Malaysia
One stop centre staging by contrast-enhanced 18F-FDG PET/CT in preoperative assessment of ovarian cancer and proposed diagnostic imaging algorithm: a single centre experience in Malaysia Open
Introduction: Suspicious adnexal masses need to be investigated thoroughly as it may represent ovarian cancer, which is the fourth most common gynaecological cancer in Malaysia. Conventional cross sectional imaging may reveal non-specific …
View article: Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms
Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms Open
EABP demonstrates the most effective hepatoprotection against PCM-induced liver injury in rats. This observation could be attributed to its remarkable antioxidant activity and the presence of flavonoids that might probably act synergistica…
View article: Germinated brown rice ameliorates obesity in high-fat diet induced obese rats
Germinated brown rice ameliorates obesity in high-fat diet induced obese rats Open
View article: Acute and sub-chronic oral toxicity studies of methanol extract of <i>Clinacanthus nutans</i> in mice
Acute and sub-chronic oral toxicity studies of methanol extract of <i>Clinacanthus nutans</i> in mice Open
Background: Clinacanthus nutans (C. nutans) Lindau (family Acanthaceae) is a shrub widely cultivated in the South East Asia region, including Malaysia. It has been traditionally used for treatment of various ailments including pain-mediate…
View article: ACUTE AND SUB-CHRONIC ORAL TOXICITY STUDIES OF METHANOL EXTRACT OF CLINACANTHUS NUTANS IN MICE
ACUTE AND SUB-CHRONIC ORAL TOXICITY STUDIES OF METHANOL EXTRACT OF CLINACANTHUS NUTANS IN MICE Open
Background: Clinacanthus nutans (C. nutans) Lindau (family Acanthaceae) is a shrub widely cultivated in the South East Asia region,
including Malaysia. It has been traditionally used for treatment of various ailments including pain-mediat…
View article: Little mind benders
Little mind benders Open
Toxoplasma gondii is a unique yet dangerous protozoan parasite. It sneaks into the brain and alters the host’s behaviour and health. Imagine how these tiny little creatures invading the brain and becoming the inner companions, hanging out …
View article: Parotid oncocytoma in Birt-Hogg-Dube syndrome: a new pitfall in 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging study
Parotid oncocytoma in Birt-Hogg-Dube syndrome: a new pitfall in 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging study Open
Oncocytomas are rare head and neck neoplasms that occur most commonly in the parotid salivary gland. Birt-Hogg-Dube syndrome is a rare inherited genodermatosis manifested by a group of cutaneous lesions, in association with several renal a…
View article: Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion
Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion Open
View article: Gastroprotective activity of chloroform extract of<i>Muntingia calabura</i>and<i>Melastoma malabathricum</i>leaves
Gastroprotective activity of chloroform extract of<i>Muntingia calabura</i>and<i>Melastoma malabathricum</i>leaves Open
CEMC and CEMM exert gastroprotective effects in animals with ethanol-induced gastric ulcers via antioxidant and anti-secretory effects.
View article: High Expression of Cyclooxygenase-2 in High Grade Human Prostate Adenocarcinoma
High Expression of Cyclooxygenase-2 in High Grade Human Prostate Adenocarcinoma Open
Inflammation plays an important role to the process of prostate carcinogenesis by increasing the rate of cell proliferation, which contributes to an aggressive tumour phenotype.Cyclooxygenase-2 (COX-2) has been found overexpressed in vario…
View article: Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves
Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves Open
MEMM exhibited a gastroprotective activity due partly to the presence of quercitrin, its antioxidant and anti-inflammatory activities, and via the modulation of NO and SH groups.
View article: Association between HOMA-IR and cancer
Association between HOMA-IR and cancer Open
Background: Type 2 diabetes which has insulin resistance as a major risk factor among other non-communicable diseases is a major public health concern with increased significance and prevalence worldwide. Cancer on the other hand was a lea…