Explanipedia

Lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study Open

Tatsuhiko Azegami, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Kazuki Aoyama , et al. · 2025

Hypertension, a leading global health challenge, is intricately linked to obesity in its pathogenesis. Body mass index, a common indicator of obesity, cannot distinguish between fat mass and lean body mass, which exert contrasting cardiova…

Prospective safety assessment of the acute vasoreactivity test using an inhaled nitric oxide delivery system in pulmonary hypertension Open

Shun Minatsuki, Masaru Hatano, Satoshi Ishii, Kazutoshi Hirose, Ryo Matsuoka , et al. · 2025

This prospective pilot study demonstrates that AVT using the INOflo system is safe and induces selective pulmonary vasodilation in PAH and selected forms of pulmonary hypertension. These findings provide device-specific safety data support…

Evolving trends of antidiabetic agents stratified by age, kidney function and body mass index: Insights from a nationwide claims database Open

Kazuki Aoyama, Akira Okada, Hidehiro Kaneko, Tatsuhiko Azegami, Yuta Suzuki , et al. · 2025

Aims To analyse prescribing trends in antidiabetic agents stratified by background characteristics among individuals with type 2 diabetes. Materials and Methods This retrospective study used a large‐scale database between 2015 and 2024 in …

Myocardial lipin1 protects the heart against ischemic injury by preserving lipid homeostasis Open

Jiaxi Guo, Kohei Karasaki, Kazutaka Ueda, Manami Katoh, Masaki Hashimoto , et al. · 2025

Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulate…

Prevalence, associated factors, and prognostic value of P wave abnormality in patients with coronary artery disease Open

Kazutoshi Hirose, Hiroyuki Kiriyama, Shun Minatsuki, Yugo Nagae, Takehiko Furusawa , et al. · 2025

Long-Term Implantable Cardioverter Defibrillator Lead Dysfunction After Left Ventricular Assist Device Implantation Open

Tsukasa Oshima, Kohei Ishibashi, Kenichiro Yamagata, Nobuhiko Ueda, Toshihiro Nakamura , et al. · 2025

In patients undergoing LVAD implantation, ICD lead dysfunction was observed in 72.9% after a mean follow-up of 46.2 months, of which two-thirds had persistence lead dysfunction. Later occurrence of lead dysfunction (>2 months after implant…

Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidance Open

Yuya Kitani, Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Hiroyuki Morita , et al. · 2025

Although body weight (BW) and waist circumference (WC) reduction are key goals of Japan’s Specific Health Guidance program, limited evidence exists linking these reductions to a lower incidence of hypertension. This study aimed to evaluate…

Multiple instance learning using pathology foundation models effectively predicts kidney disease diagnosis and clinical classification Open

Yu Kurata, Imari Mimura, Satoshi Kodera, Hiroyuki Abé, Daisuke Yamada , et al. · 2025

Right Ventricular Systolic and Diastolic Parameters on the Basis of Pressure-Volume Loop Theory in Patients With Heart Failure Open

Yoshitaka Isotani, Eisuke Amiya, Masaru Hatano, Junichi Ishida, Masaki Tsuji , et al. · 2025

RV waveform evaluation based on PV loop theory was effective in predicting prognosis in HF patients, irrespective of LVEF.

Early Withdrawal From Continuous Intravenous Infusion and Delirium in Heart Failure Open

Hideaki Sowa, Tetsuhiko Tange, Yusuke Nakano, Yoriyasu Suzuki, Yugo Nara , et al. · 2025

Pregnant Patient With Infrarenal Abdominal Aortic Aneurysm Successfully Treated With EVAR Open

Tomomi Ueda, Hiroki Yagi, Nana Akiyama, Naoya Akiba, Katsuyuki Hoshina , et al. · 2025

EVAR could be an effective treatment option during pregnancy if radiation exposure is properly minimized. Multidisciplinary collaboration, including early evaluation for connective tissue diseases, is essential to evaluate treatment strate…

Enhancing Chest Radiography Artificial Intelligence Model with Electrocardiogram for Improved Detection of Low Ejection Fraction Open

Masataka Satô, Satoshi Kodera, S Hamano, Naoto Setoguchi, Kengo Tanabe , et al. · 2025

Artificial intelligence models reportedly detect a low ejection fraction (EF) with chest radiography (CXR) examinations, which traditionally require a transthoracic echocardiogram (TTE) for evaluation. However, whether coupling a CXR model…

Emerging Role of AI in Cardiovascular Medicine Open

Satoshi Kodera, Norihiko Takeda · 2025

Total Atrial Conduction Time as a Predictor of Left Atrial Functional Recovery in Atrial Fibrillation Open

Hikari Seki, Koki Nakanishi, Masao Daimon, Kazutoshi Hirose, Kentaro Iwama , et al. · 2025

The measurement of PA-TDI duration provided valuable information for LA functional recovery in AF patients who underwent CA.

Constipation and Incident Cardiovascular Disease Open

Keiichiro Iwasaki, Kentaro Ejiri, Hidehiro Kaneko, Yuta Suzuki, Toru Miyoshi , et al. · 2025

In individuals without prior CVD, constipation was associated with incident CVDs including myocardial infarction, angina pectoris, stroke, HF, and AF. Constipation may be promising for the prediction of future CVD other than established ri…

Fibrosis 4 Index Predicts Haemocompatibility-Related Adverse Events in Patients Using Left Ventricular Assist Devices Open

Takahiro Kurihara, Eisuke Amiya, Masaru Hatano, Junichi Ishida, Chie Bujo , et al. · 2025

Background This study aimed to explore the association between the liver fibrosis-4 (FIB4) index and clinical events, specifically haemocompatibility-related adverse events (HRAEs), in patients who underwent left ventricular assist device …

Cardiovascular-kidney-metabolic syndrome stage predicts cardiovascular outcomes in cancer patients: a real-world data analysis of a nationwide epidemiological dataset Open

Toshiyuki Ko, Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Takahiro Jimba , et al. · 2025

Aims Cancer survivors are at increased cardiovascular risk due to shared risk factors and treatment-related toxicity. The recently proposed cardiovascular-kidney-metabolic (CKM) syndrome framework provides a novel approach for cardiometabo…

Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure Open

Kaori Kitaoka, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Atsushi Mizuno , et al. · 2025

End-of-life decision-making and changing preferences in patients with a left ventricular assist device for destination therapy: insights from advance directives in Japan Open

Toshihide Izumida, Eisuke Amiya, Masaru Hatano, Junichi Ishida, Miki Kanno , et al. · 2025

Inspiratory muscle training after atrial fibrillation catheter ablation: A pilot study Open

Yan Li, Eisuke Amiya, Katsuhito Fujiu, Masanobu Taya, Tsukasa Oshima , et al. · 2025

Atrial fibrillation management is challenging, and traditional cardiac rehabilitation often overlooks respiratory issues. We aimed to evaluate the safety and efficacy of cardiac rehabilitation with inspiratory muscle training to enhance re…

PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes Open

Toshinaru Kawakami, S. Hosokawa, Masamichi Ito, Atsumasa Kurozumi, Ryohei Tanaka , et al. · 2025

Single-cell RNA sequencing (scRNA-seq) of patient samples holds promise for understanding disease mechanisms, but faces the challenge of excessive cost and effort in acquisition, processing, and data analysis, making it essential to levera…

Prognostic Factors Associated With Early Recovery From Veno‐Arterial Extracorporeal Membrane Oxygenation Support in Patients With Fulminant Myocarditis Open

Tomomi Ueda, Eisuke Amiya, Masaru Hatano, Kosuke Inoue, Junichi Ishida , et al. · 2025

Background Fulminant myocarditis is life‐threatening and often requires mechanical circulatory support. Predicting its clinical course is crucial, yet data on early recovery predictors, particularly with veno‐arterial extracorporeal membra…

Multiple instance learning using pathology foundation models effectively predicts kidney disease diagnosis and clinical classification Open

Yu Kurata, Imari Mimura, Satoshi Kodera, Hiroyuki Abé, Daisuke Yamada , et al. · 2025

Introduction Histological analysis of kidney biopsies is crucial in diagnosing kidney diseases and predicting clinical outcomes. Recently developed pathology foundation models, pretrained on large-scale pathology datasets, have demonstrate…

Altered Bone Marrow Niche Forms Central Innate Immune Memory Driving Cardiac Dysfunction Open

Katsuhito Fujiu, Kohsaku Goto, Yukiteru Nakayama, Junichi Sugita, Tsukasa Oshima , et al. · 2025

We previously showed that heart failure (HF) induces innate immune memory in hematopoietic stem/progenitor cells (HSPCs), which crucially contributes to HF recurrence and impaired stress responses in multiple organs. While bone marrow (BM)…

Genotype‐guided cardiac device intervention in <span><i>LMNA</i></span>‐related cardiac conduction disorder: The need for timely genetic testing Open

Shunsuke Inoue, Zhehao Dai, Tsukasa Oshima, Seitaro Nomura, Takashi Hiruma , et al. · 2025

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets Open

Kazutoshi Hirose, Satoshi Kodera, Masako Nishikawa, Masataka Sato, Yuqi Zhou , et al. · 2025

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately,…

Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM) Open

Yasutomi Higashikuni, Colin Platt, Margaret H. Hastings, Chien‐Wen Chen, Justin Ralph Baldovino Guerra , et al. · 2025

Vaccination-based immunotherapy to target profibrotic cells in liver and lung Open

Michal Sobecki, Jing Chen, Ewelina Krzywińska, Shunmugam Nagarajan, Fan Zheng , et al. · 2025

CAG-VLM: Fine-Tuning of a Large-Scale Model to Recognize Angiographic Images for Next-Generation Diagnostic Systems Open

Yuto Nakamura, Satoshi Kodera, Haruki Settai, Hiroki Shinohara, Masatsugu Tamura , et al. · 2025

Coronary angiography (CAG) is the gold-standard imaging modality for evaluating coronary artery disease, but its interpretation and subsequent treatment planning rely heavily on expert cardiologists. To enable AI-based decision support, we…

Association between Rheumatoid Arthritis and the Incidence of IgA Nephropathy Open

Tatsuhiko Azegami, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Katsuhito Fujiu , et al. · 2025

Introduction: IgA nephropathy and rheumatoid arthritis are both common autoimmune diseases, but epidemiological data are limited on the relationship between these two diseases. We aimed to assess the association between rheumatoid arthriti…

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