Norihisa Nishida
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View article: Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans
Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans Open
Paramylon (PM), an insoluble β-1,3-glucan produced by Euglena gracilis , reportedly possesses immunomodulatory and metabolic regulatory effects. However, its effect on longevity remains unclear. For this study, using Caenorhabditis elegans…
View article: High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study
High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study Open
Paramylon, a characteristic β-glucan of microalgae Euglena gracilis, modulates immune function. However, data on its mechanism of action and use in humans are limited. We conducted a 12-week randomized controlled trial to determine the eff…
View article: Effects of paramylon‐rich <i>Euglena gracilis</i><scp>EOD</scp>‐1 powder on visceral fat obesity in moderately obese Japanese adults: A randomized, <scp>double‐blind</scp>, <scp>placebo‐controlled</scp>, <scp>parallel‐group</scp> trial
Effects of paramylon‐rich <i>Euglena gracilis</i><span>EOD</span>‐1 powder on visceral fat obesity in moderately obese Japanese adults: A randomized, <span>double‐blind</span>, <span>placebo‐controlled</span>, <span>parallel‐group</span> trial Open
To investigate whether supplementation of paramylon (PM)‐rich Euglena gracilis EOD‐1 powder (EOD‐1) reduces visceral fat obesity in moderately obese Japanese subjects. A randomized, double‐blind, placebo‐controlled intervention study was c…
View article: Dectin-1 Reactivity to Paramylon Derived from <i>Euglena gracilis</i> EOD-1
Dectin-1 Reactivity to Paramylon Derived from <i>Euglena gracilis</i> EOD-1 Open
Euglena gracilis is a microalga that has recently attracted attention because of its bioactivities. Paramylon (PM), a major β-1,3-glucan, constitutes 70-80% of the cells of the E. gracilis EOD-1 strain. Dectin-1 is a pattern recognition re…
View article: Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial
Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial Open
Euglena gracilis EOD-1, a kind of microalgae, is known to contain a high proportion of paramylon, a type of β-1,3-glucan. Paramylon derived from E. gracilis EOD-1 is presumed to suppress cellular oxidative injury and expected to reduce fat…
View article: Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice
Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice Open
Paramylon (PM), a type of β-glucan, functions like dietary fiber, which has been suggested to exert a protective effect against obesity. We evaluated the potential beneficial effects of PM powder on obesity in mice. Male C57BL/6J mice were…
View article: The Inhibitory Effect of a Polyphenol Concentrate from Pomegranate Juice on 2,4-dinitrofluorobenzene-induced Contact Hypersensitivity in Mice
The Inhibitory Effect of a Polyphenol Concentrate from Pomegranate Juice on 2,4-dinitrofluorobenzene-induced Contact Hypersensitivity in Mice Open
Pomegranate juice (PJ) has higher polyphenol content and antioxidative activity than any other fruit juice. We used a pomegranate polyphenol concentrate (PPC) from pomegranate juice and investigated its inhibitory effects and mechanism of …
View article: Physico-Chemical Characteristics of Pomegranate Harvested in Yamanashi Prefecture in Japan
Physico-Chemical Characteristics of Pomegranate Harvested in Yamanashi Prefecture in Japan Open
To elucidate the physico-chemical properties of the juice and the fruit as a whole for pomegranates harvested in the Yamanashi prefecture in Japan compared to that of the imported ones, following analysis were conducted. ① On average, the …
View article: Pomegranate‐Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3‐Mediated SOD2 Activation
Pomegranate‐Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3‐Mediated SOD2 Activation Open
Pomegranate‐derived polyphenols are expected to prevent life‐style related diseases. In this study, we evaluated the ability of 8 pomegranate‐derived polyphenols, along with other polyphenols, to augment SIRT3 , a mammalian SIR2 homolog lo…
View article: 650. Development of Combination Therapy of Bifidobacterium-Based Oral Vaccine Displaying HCV-NS3 with Interferon-α
650. Development of Combination Therapy of Bifidobacterium-Based Oral Vaccine Displaying HCV-NS3 with Interferon-α Open
INTRODUCTION: Hepatitis C virus (HCV) is a major cause of chronic liver diseases, such as liver cirrhosis and hepatocellular carcinoma. The efficacy of the standard-of-care including interferon-α and ribavirin for chronic HCV infection is …
View article: Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial
Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial Open
These results suggest that rosehip extract may be a good candidate food material for preventing obesity.
View article: The Mechanism of Decreased Serum Phosphorus Levels in Rats with Chronic Kidney Disease after Oral Administration of &lt;i&gt;Bifidobacterium longum&lt;/i&gt;
The Mechanism of Decreased Serum Phosphorus Levels in Rats with Chronic Kidney Disease after Oral Administration of <i>Bifidobacterium longum</i> Open
Chronic kidney disease (CKD) patients are prone to disturbances in the intestinal microbiota, which contributes to CKD progression and complications. We previously reported a reduction of serum phosphorus (P) levels in hemodialysis patient…