Norihito Okumura
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View article: Association of the expression of 5‑FU biomarkers with aging and prognosis in elderly patients with lung cancer treated with S‑1 adjuvant chemotherapy: Follow‑up results of the Setouchi Lung Cancer Group Study 1201
Association of the expression of 5‑FU biomarkers with aging and prognosis in elderly patients with lung cancer treated with S‑1 adjuvant chemotherapy: Follow‑up results of the Setouchi Lung Cancer Group Study 1201 Open
Managing elderly patients presents several challenges because of age-related declines; however, age should not be the sole determinant for adjuvant treatment decisions in patients with non-small cell lung cancer (NSCLC). Moreover, age may …
View article: Predictive Value of Tumor ERCC1 Expression for Treatment Outcomes After Adjuvant Chemotherapy in Patients with Completely Resected Non-Small Cell Lung Cancer
Predictive Value of Tumor ERCC1 Expression for Treatment Outcomes After Adjuvant Chemotherapy in Patients with Completely Resected Non-Small Cell Lung Cancer Open
In completely resected NSCLC patients with positive tumor ERCC1 expression, adjuvant CBDCA+PTX treatment tended to yield an inferior outcome as compared with UFT treatment in terms of the OS. However, immunohistochemical analysis with the …
View article: Implication of S-1 biomarkers on aging and prognosis in elderly patients with lung cancer treated by adjuvant S-1 chemotherapy: Accompanying results of the Setouchi Lung Cancer Group Study 1201
Implication of S-1 biomarkers on aging and prognosis in elderly patients with lung cancer treated by adjuvant S-1 chemotherapy: Accompanying results of the Setouchi Lung Cancer Group Study 1201 Open
BACKGROUNDS The management of elderly patients presents several challenges due to age-related declines; however recent recommendations advocate for age not being the sole determinant for adjuvant treatment decisions in patients with non-sm…
View article: Predictive Value of PERCIST for Locally Advanced Non-Small Cell Lung Cancer Treated with Preoperative Induction Therapy – A Multicenter Study in Japan
Predictive Value of PERCIST for Locally Advanced Non-Small Cell Lung Cancer Treated with Preoperative Induction Therapy – A Multicenter Study in Japan Open
Our study suggested that PERCIST, especially the rate of TLG reduction rate, are useful to predict the pathological response and prognosis after induction therapy. Although improvement is necessary, PERCIST can be a promising method of the…
View article: P1.26-08 Usefulness and Safety of Chest Tube Removal Regardless of Drainage Volume of Pleural Effusion in Patients Who Underwent Pulmonary Resection
P1.26-08 Usefulness and Safety of Chest Tube Removal Regardless of Drainage Volume of Pleural Effusion in Patients Who Underwent Pulmonary Resection Open
View article: Randomized phase II study of daily versus alternate-day administrations of S-1 for the elderly patients with completely resected pathological stage IA (tumor diameter > 2 cm)—IIIA of non-small cell lung cancer: Setouchi Lung Cancer Group Study 1201
Randomized phase II study of daily versus alternate-day administrations of S-1 for the elderly patients with completely resected pathological stage IA (tumor diameter > 2 cm)—IIIA of non-small cell lung cancer: Setouchi Lung Cancer Group Study 1201 Open
Background It is shown that the postoperative adjuvant chemotherapy for non-small cell lung cancer (NSCLC) was associated with survival benefit in an elderly population. We aimed to analyze the feasibility and efficacy of alternate-day S-1…
View article: Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment for postoperative recurrent <i>EGFR</i>-mutated lung adenocarcinoma: a multi-institutional retrospective study
Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment for postoperative recurrent <i>EGFR</i>-mutated lung adenocarcinoma: a multi-institutional retrospective study Open
OBJECTIVES The aim of this study was to analyse the long-term survival outcomes and prognostic factors of patients receiving epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as first-line treatment for postoperative …
View article: Predictive value of <i>EGFR</i> mutation in non–small‐cell lung cancer patients treated with platinum doublet postoperative chemotherapy
Predictive value of <i>EGFR</i> mutation in non–small‐cell lung cancer patients treated with platinum doublet postoperative chemotherapy Open
The mutation status of tumor tissue DNA (n = 389) of resected stage II‐III non‐squamous non–small‐cell lung cancer (Ns‐NSCLC) was analyzed using targeted deep sequencing as an exploratory biomarker study (JIPANG‐TR) for the JIPANG study, a…
View article: Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Background The aim of this multicenter, randomized phase II study was to analyze the feasibility and safety of alternate-day S-1, an oral fluoropyrimidine, for adjuvant chemotherapy in patients with completely resected pathological stage I…
View article: Additional file 4 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 4 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 4. Online Resource 4. Method for dose reduction of S-1.
View article: Segmentectomy Versus Lobectomy in Small-Sized Peripheral Non-Small Cell Lung Cancer (JCOG0802/WJOG4607L): A Multicentre, Randomised, Controlled, Phase 3 Trial
Segmentectomy Versus Lobectomy in Small-Sized Peripheral Non-Small Cell Lung Cancer (JCOG0802/WJOG4607L): A Multicentre, Randomised, Controlled, Phase 3 Trial Open
View article: Additional file 6 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 6 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 6. Online resourse 6. Follow-up assessment.
View article: Additional file 3 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 3 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 3. Online Resource 3. Criteria for dose reduction.
View article: Additional file 2 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Additional file 2 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301 Open
Additional file 2. Online Resource 2. The criteria for discontinuation and restant of S-1 administration.
View article: Tumor mutation burden as a biomarker for lung cancer patients treated with pemetrexed and cisplatin (the JIPANG‐TR)
Tumor mutation burden as a biomarker for lung cancer patients treated with pemetrexed and cisplatin (the JIPANG‐TR) Open
The JIPANG study is a randomized phase III study of pemetrexed/cisplatin (Pem/Cis) versus vinorelbine/cisplatin (Vnr/Cis) for completely resected stage II‐IIIA non‐squamous non‐small cell lung cancer (Ns‐NSCLC). This study did not meet the…
View article: Abstract No. 588 Success rate and complications of indocyanine green and lipiodol mixture with fat emulsion for computed tomography–guided pulmonary marking before video-assisted thoracic surgery: a retrospective comparison with short hook wire
Abstract No. 588 Success rate and complications of indocyanine green and lipiodol mixture with fat emulsion for computed tomography–guided pulmonary marking before video-assisted thoracic surgery: a retrospective comparison with short hook wire Open
View article: A Phase III Study of Adjuvant Chemotherapy in Patients with Completely Resected, Node-Negative Non-Small Cell Lung Cancer
A Phase III Study of Adjuvant Chemotherapy in Patients with Completely Resected, Node-Negative Non-Small Cell Lung Cancer Open
View article: P2.18-15 Surgical Outcomes of Pneumonectomy After Induction Therapy for Non-Small-Cell Lung Cancer
P2.18-15 Surgical Outcomes of Pneumonectomy After Induction Therapy for Non-Small-Cell Lung Cancer Open
View article: Nine surgical cases of childhood congenital cystic lung disease
Nine surgical cases of childhood congenital cystic lung disease Open
今回我々は2006年から2015年の10年間に当科で手術を行った新生児・乳児を含む先天性囊胞性肺疾患小児例9例を検討した．疾患の内訳はCCAMは6例，肺リンパ管腫は1例，肺分画症は2例であった．男児が6例，女児が3例であった．患児の年齢は生後28日は1例，9ヵ月は1例，1歳は2例，3歳は1例，4歳は2例，5歳は1例，7歳は1例であった．このうち緊急手術は2例で，ともに囊胞の巨大化による縱隔偏位を認め，呼吸促迫で来院した．病変の局在は右上葉は1例，右下葉は3例，左下葉は5例で…
View article: A case of progressive pulmonary pleomorphic carcinoma showing long-term relapse-free survival due to multidisciplinary treatment
A case of progressive pulmonary pleomorphic carcinoma showing long-term relapse-free survival due to multidisciplinary treatment Open
58歳男性．4ヵ月持続する右胸背部痛を主訴に来院，胸部X線上右上肺野に腫瘤影を認め紹介となった．胸部CT上右上葉に胸壁に接する42 mm大の腫瘤影を認め，近傍の肋骨辺縁は不整であり胸壁浸潤が疑われた．術前確定診断は得られずも原発性肺癌（cT3N0M0 cStage IIB）を疑い手術の方針とした．手術は後側方切開，右上葉切除及び第3～5肋間筋を含む胸壁合併切除（ND2a）を施行した．術中穿刺吸引細胞診では低分化癌，術後病理診断にて肺原発多形癌（pT3N0M0 stage I…
View article: Operation for stage IV lung cancer with severe lung abscess that developed during chemotherapy
Operation for stage IV lung cancer with severe lung abscess that developed during chemotherapy Open
肺癌に対する化学療法は，感染症の合併により継続困難や致命的となることがある．われわれは，肺癌化学療法中に肺膿瘍を合併し，抗菌薬投与では改善せず，手術により感染制御できた一例を経験した．症例は64歳男性．右上葉原発のIV期非小細胞肺癌に対して化学療法中に閉塞性肺炎を発症．抗菌薬加療では改善せず肺膿瘍に進展し，膿瘍は徐々に腫大．胸腔内穿破による膿胸への移行が懸念されたため，感染制御目的に手術施行．開胸時，右上葉は胸腔内の1/2を占めるまで腫大していた．腫瘍の下葉浸潤と主気管支周…
View article: Right extrapleural completion pneumonectomy for fibrocavitary nontuberculous mycobacterial lung disease
Right extrapleural completion pneumonectomy for fibrocavitary nontuberculous mycobacterial lung disease Open
Key Clinical Message We report a case of a 76‐year‐old man with fibrocavitary nontuberculous mycobacterial ( FC ‐ NTM ) lung disease, who was successfully treated with right extrapleural completion pneumonectomy. Right extrapleural complet…
View article: A case of video-assisted thoracoscopic lobectomy for intralobar pulmonary sequestration in an infant
A case of video-assisted thoracoscopic lobectomy for intralobar pulmonary sequestration in an infant Open
症例は3歳男児．胎児期より胎児エコーで肺分画症を疑われていた．出生時より呼吸状態は安定しており，重篤な合併症もなかった．そのため，麻酔科医師と相談して，体格的に胸腔鏡下手術が可能な分離肺換気を安全に行える時期まで児の成長を待ち，待機的に手術を行う方針としていた．胸部CTでは下行大動脈から左肺底区に流入する1本の異常血管を認め，Pryce III型の肺葉内肺分画症と診断した．手術目的に当科入院となった．手術は完全鏡視下左下葉切除および異常動脈切断術を施行した．幼児での肺葉内肺…
View article: A case of radically resected pulmonary adenocarcinoma with pulmonary embolism during induction chemotherapy
A case of radically resected pulmonary adenocarcinoma with pulmonary embolism during induction chemotherapy Open
肺塞栓症は重篤な周術期合併症の一つであり，担癌状態や化学療法はそのリスク因子と考えられている．今回導入化学療法中に肺塞栓症を発症するも，抗凝固療法後に根治的手術を行い得た一例を経験したので報告する．症例は73歳女性．既往は脂質代謝異常症．健診胸部レントゲンで異常陰影を指摘され，精査の結果，肺腺癌，cT2aN2M0，IIIA期の診断を得，導入化学療法後の手術を予定した．シスプラチン，ペメトレキセド，ベバシズマブによる治療を3コース行った後，造影CTで右肺動脈本幹に広範な血栓を…
View article: Development and validation of a preoperative prognostic index independent of TNM stage in resected non-small cell lung cancer
Development and validation of a preoperative prognostic index independent of TNM stage in resected non-small cell lung cancer Open
We developed and validated a simple preoperative prognostic index composed of seven variables, which may help clinicians predict prognosis before surgery in patients with NSCLC.
View article: A proposal for a comprehensive risk scoring system for predicting postoperative complications in octogenarian patients with medically operable lung cancer: JACS1303
A proposal for a comprehensive risk scoring system for predicting postoperative complications in octogenarian patients with medically operable lung cancer: JACS1303 Open
JACS1303 (UMIN000016756).
View article: Surgical and survival outcomes of lung cancer patients with intratumoral lung abscesses
Surgical and survival outcomes of lung cancer patients with intratumoral lung abscesses Open
View article: Induction Chemoradiotherapy Followed by Surgery in Stage IIIA/N2 Non-small-cell Lung Cancer: a Retrospective Study
Induction Chemoradiotherapy Followed by Surgery in Stage IIIA/N2 Non-small-cell Lung Cancer: a Retrospective Study Open
━━ Objective.The aim of this study was to investigate the outcomes of induction chemoradiotherapy followed by surgery in patients with stage IIIA/N2 non-small-cell lung cancer (NSCLC).Methods.We retrospectively analyzed 48 consecutive pati…
View article: Pneumonectomy for bronchial primary inflammatory myofibroblastic tumor with bronchial growth
Pneumonectomy for bronchial primary inflammatory myofibroblastic tumor with bronchial growth Open
症例は75歳，男性．咳嗽・喀痰・労作時呼吸困難が出現し近医を受診．肺炎の診断で抗生剤加療開始も症状の改善なく，1週間後の胸部Xpで左下肺野の透過性低下進行のため，当院呼吸器内科を紹介受診となった．気管支鏡で左主気管支を閉塞する腫瘍を認め，生検で扁平上皮癌と診断した．肺癌（cT3N0M0 stage IIB）の評価で左上下葉は完全無気肺であり，左肺全摘術を施行した．術後経過は良好であり，術後2日目に胸腔ドレーンを抜去し，術後7日目に退院となった．術後病理診断では炎症性筋線維芽…
View article: Unilateral pleuroperitoneal shunt placement for bilateral intractable pleural effusion caused by right heart and renal failure
Unilateral pleuroperitoneal shunt placement for bilateral intractable pleural effusion caused by right heart and renal failure Open
コントロール困難な胸水貯留に対して胸腔腹腔シャント造設により良好な経過を得た症例報告が散見される．今回我々は両側の難治性漏出性胸水に対して，片側の胸腔腹腔シャント造設により良好なコントロールを得た症例を経験した．症例は79歳男性．当科にて肺癌に対して左上葉切除施行．術後9ヵ月後心不全の増悪，腎機能低下にて他院入院．頻回の胸腔穿刺を要する右優位の難治性両側胸水貯溜を認め，当院へ転院となった．透析を導入し内科的加療を行うも胸水貯溜が進行するため胸腔腹腔シャント造設の方針とした．…