Norikazu Sakakibara
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View article: Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity Open
We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheime…
View article: Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors
Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors Open
Aims Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan. The causative virus severe fever with thrombocytopenia syndrome v…
View article: Synthesis and Evaluation of Novel Cyclopropane Nucleoside as Potential Tube Formation Agents
Synthesis and Evaluation of Novel Cyclopropane Nucleoside as Potential Tube Formation Agents Open
Five novel nucleoside analogs with mono or bis-hydroxymethylated cyclopropane rings at the N9-position of the 2-chloroadenine moiety (2-chloro-carbocyclic oxetanocin A [COA-Cl] analog) were synthesized and evaluated using human umbilical v…
View article: A key role of PGC-1<i>α</i> transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts
A key role of PGC-1<i>α</i> transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts Open
We previously demonstrated a potent angiogenic effect of a newly developed adenosine-like agent namedCOA-Cl.COA-Cl exerted tube forming activity in human umbilical vein endothelial cells in the presence of normal human dermal fibroblasts (…