Noriko Kimura
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View article: Chromosome-scale genomes of two wild flowering cherries ( <i>Cerasus itosakura</i> and <i>Cerasus jamasakura</i> ) provide insights into structural evolution in <i>Cerasus</i>
Chromosome-scale genomes of two wild flowering cherries ( <i>Cerasus itosakura</i> and <i>Cerasus jamasakura</i> ) provide insights into structural evolution in <i>Cerasus</i> Open
Flowering cherries (genus Cerasus) are iconic trees in Japan, celebrated for their cultural and ecological significance. Despite their prominence, high-quality genomic resources for wild Cerasus species have been limited. Here, we report c…
View article: Chromosome-scale genomes of two wild flowering cherrys (<i>Cerasus itosakura</i> and <i>C. jamasakura</i>) provide insights into structural evolution in <i>Prunus</i>
Chromosome-scale genomes of two wild flowering cherrys (<i>Cerasus itosakura</i> and <i>C. jamasakura</i>) provide insights into structural evolution in <i>Prunus</i> Open
Flowering cherries (genus Cerasus ) are iconic trees in Japan, celebrated for their cultural and ecological significance. Despite their prominence, high-quality genomic resources for wild Cerasus species have been limited. Here, we report …
View article: A case of idiopathic mesenteric phlebosclerosis: Insight into pathogenesis of associated vascular calcification
A case of idiopathic mesenteric phlebosclerosis: Insight into pathogenesis of associated vascular calcification Open
A 75‐year‐old woman had been taking a geniposide‐containing herbal medicine for 7 years and was admitted to our hospital for nausea, abdominal pain, and distention. CT revealed colonic wall thickening, whereas CS revealed a dark‐purple ede…
View article: Successful resection and diagnosis of primary gastric myxoid liposarcoma using endoscopic submucosal dissection
Successful resection and diagnosis of primary gastric myxoid liposarcoma using endoscopic submucosal dissection Open
View article: A Near Complete Genome Assembly of the Oshima Cherry Cerasus speciosa
A Near Complete Genome Assembly of the Oshima Cherry Cerasus speciosa Open
View article: A Case of Rectal Gastrointestinal Stromal Tumor Resected by Transanal Total Mesorectal Excision after Neoadjuvant Imatinib Treatment
A Case of Rectal Gastrointestinal Stromal Tumor Resected by Transanal Total Mesorectal Excision after Neoadjuvant Imatinib Treatment Open
View article: Clinicopathological and genomic analysis of pediatric pheochromocytoma and sympathetic paraganglioma
Clinicopathological and genomic analysis of pediatric pheochromocytoma and sympathetic paraganglioma Open
Pediatric patients with pheochromocytoma (PCC)/paraganglioma (PGL) (PPGL) are rare, and clinicopathological investigations, especially the relationship between gene analysis and histological features, are insufficient. We comprehensively e…
View article: Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025
Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025 Open
Pheochromocytomas and paragangliomas are characterized by two key features: endocrine disorders with excessive catecholamine secretion and a hereditary or metastatic nature, making early diagnosis and treatment crucial. This clinical pract…
View article: Simultaneous Resection of Esophageal Carcinosarcoma with Cancer of the Stomach and Transverse Colon: A Case Report
Simultaneous Resection of Esophageal Carcinosarcoma with Cancer of the Stomach and Transverse Colon: A Case Report Open
We report a rare case of triple cancer, including esophageal carcinosarcoma. Simultaneous resection of esophageal carcinosarcoma with multiple cancers should be carefully considered based on the patient's condition and reconstruction metho…
View article: Advanced Gastric Cancer with Mediastinal Dissemination Mimicking Mediastinitis
Advanced Gastric Cancer with Mediastinal Dissemination Mimicking Mediastinitis Open
View article: Decoding the Centromeric Region with a Near Complete Genome Assembly of the Oshima Cherry<i>Cerasus speciosa</i>
Decoding the Centromeric Region with a Near Complete Genome Assembly of the Oshima Cherry<i>Cerasus speciosa</i> Open
The Oshima cherry ( Cerasus speciosa ), which is endemic to Japan, has significant cultural and horticultural value. In this study, we present a near complete telomere-to-telomere genome assembly for C. speciosa , derived from the old grow…
View article: Long-term follow-up of patients developing gastric mucosal lesions after initiating the potassium-competitive acid blocker vonoprazan
Long-term follow-up of patients developing gastric mucosal lesions after initiating the potassium-competitive acid blocker vonoprazan Open
Vonoprazan has recently been developed and approved for clinical use in Japan 1 as a drug of the potassium-competitive acid blocker (P-CAB) class reported to reversibly inhibit gastric acid output through K + -competitive ionic binding to …
View article: Potassium-competitive acid blocker-associated gastric mucosal lesions
Potassium-competitive acid blocker-associated gastric mucosal lesions Open
Since the introduction of vonoprazan, a potassium-competitive acid blocker (P-CAB), it has been demonstrated to reversibly inhibit gastric acid secretion by engaging in potassium-competitive ionic binding to H+/K+-ATPase. In contrast, prot…
View article: Emergency Endoscopic Hemostasis Using the Endoscopic Mucosal Resection Technique for Severe Bleeding From Early Gastric Cancer: A Case Report
Emergency Endoscopic Hemostasis Using the Endoscopic Mucosal Resection Technique for Severe Bleeding From Early Gastric Cancer: A Case Report Open
View article: A Case of Duodenal Adenocarcinoma Effectively Highlighted by Linked Color Imaging and Confirmed by Histopathology
A Case of Duodenal Adenocarcinoma Effectively Highlighted by Linked Color Imaging and Confirmed by Histopathology Open
While the differential diagnosis of duodenal adenocarcinoma versus adenoma remains the key to determining treatment strategies in patients with suspected duodenal adenocarcinoma, the role of linked color imaging (LCI) in their differential…
View article: Emergency Endoscopic Hemostasis of Early Postoperative Sigmoid Anastomotic Bleeding
Emergency Endoscopic Hemostasis of Early Postoperative Sigmoid Anastomotic Bleeding Open
View article: Mixed invasive mucinous and non-mucinous adenocarcinoma of the lung with hematogenous metastases to multiple organs
Mixed invasive mucinous and non-mucinous adenocarcinoma of the lung with hematogenous metastases to multiple organs Open
View article: Narrow Band Imaging Facilitates the Diagnosis of Esophageal Basaloid Squamous Cell Carcinoma
Narrow Band Imaging Facilitates the Diagnosis of Esophageal Basaloid Squamous Cell Carcinoma Open
View article: Gastric Gastrointestinal Stromal Tumor Associated With Hyperplastic Polypoid Nodules
Gastric Gastrointestinal Stromal Tumor Associated With Hyperplastic Polypoid Nodules Open
View article: Myasthenia Gravis Associated With Pembrolizumab for Relapsed Lung Cancer After Thymoma Resection
Myasthenia Gravis Associated With Pembrolizumab for Relapsed Lung Cancer After Thymoma Resection Open
View article: Invasive lobular carcinoma of the breast with colonic metastasis: a case series of three patients
Invasive lobular carcinoma of the breast with colonic metastasis: a case series of three patients Open
View article: Multiple endocrine neoplasia type 1 with Zollinger–Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry
Multiple endocrine neoplasia type 1 with Zollinger–Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry Open
Background Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the occurrence of multiple epithelial neuroendocrine tumors (NETs) and non-NETs in various organs. MEN1 encodes a 610-amino acid-long …
View article: Reliable measurement methods for the isovolumic relaxation time: comparisons of dual gate Doppler and seven other methods
Reliable measurement methods for the isovolumic relaxation time: comparisons of dual gate Doppler and seven other methods Open
Purpose Isovolumic relaxation time (IVRT) is a useful indicator of diastolic dysfunction. However, a measurement method for IVRT has not been established. The Dual Gate Doppler method, which can record two separate pulse-wave Doppler signa…
View article: Abdominal nonfunctional paraganglioma in which succinate dehydrogenase subunit B (SDHB) immunostaining was performed: a case report
Abdominal nonfunctional paraganglioma in which succinate dehydrogenase subunit B (SDHB) immunostaining was performed: a case report Open
Background Abdominal nonfunctional paraganglioma is rare. Malignant potential of paraganglioma is assessed by Grading of Adrenal Pheochromocytoma and Paraganglioma score and genetic testing, but genetic testing is not common. We present a …
View article: Invasive thymoma metastases to the pancreas: A case report
Invasive thymoma metastases to the pancreas: A case report Open
View article: A rare case of multiple paragangliomas in the head and neck, retroperitoneum and duodenum: A case report and review of the literature
A rare case of multiple paragangliomas in the head and neck, retroperitoneum and duodenum: A case report and review of the literature Open
Pheochromocytomas and paragangliomas (PGLs) are rare non-epithelial neuroendocrine neoplasms of the adrenal medulla and extra-adrenal paraganglia respectively. Duodenal PGL is quite rare and there are only two previous reports. Herein, we …
View article: Mixed corticomedullary tumor of the adrenal gland
Mixed corticomedullary tumor of the adrenal gland Open
Mixed corticomedullary tumor (MCMT) of the adrenal gland is an extremely rare tumor characterized by an admixture of steroidogenic cells and chromaffin cells in a single tumor mass simultaneously producing adrenocortical hormones and catec…
View article: A Case of 123I-Metaiodobenzylguanidine Scintigraphy-Negative Pheochromocytoma with a Tumor-Developing Mutation in the RET Gene
A Case of 123I-Metaiodobenzylguanidine Scintigraphy-Negative Pheochromocytoma with a Tumor-Developing Mutation in the RET Gene Open
Pheochromocytoma (PCC) is rare catecholamine-producing endocrine tumor that metastasizes in approximately 10% of cases. As a functional imaging of PCC, 123I-metaiodobenzylguanidine (MIBG) scintigraphy was established, and some cases of PCC…
View article: Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report
Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report Open
Background Ectopic ACTH-dependent Cushing syndrome is rarely caused by pheochromocytoma (PCC). Glucocorticoid-regulated positive feedback loops in ACTH and catecholamines were proposed in some similar cases. Case presentation We present he…
View article: Genetic Analysis of Pheochromocytoma and Paraganglioma Complicating Cyanotic Congenital Heart Disease
Genetic Analysis of Pheochromocytoma and Paraganglioma Complicating Cyanotic Congenital Heart Disease Open
Context Pheochromocytoma and paraganglioma (PPGL) may appear as a complication of cyanotic congenital heart disease (CCHD-PPGL) with frequent EPAS1 mutations, suggesting a close link between EPAS1 mutations and tissue hypoxia in CCHD-PPGL …