Noriko Motoi
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View article: Supplementary Figure S10 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S10 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S10. IHC staining of macrophages in the tumor treated with alectinib and anti-PD-L1 inhibitor. A
View article: Data from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Data from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Tyrosine kinase inhibitors are initially efficacious against anaplastic lymphoma kinase (ALK) fusion gene–positive lung adenocarcinoma, but acquired resistance inevitably occurs. Therefore, alternative treatment strategies are neede…
View article: Supplementary Figure S11 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S11 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S11. IL-6 produced by cancer cells decreases CD8+T cell-attractant chemokine gene expression and induces MDSC.
View article: Supplementary Table S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Table S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Table S1
View article: Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S2. CD8+ T cell-attractant chemokine gene expression in UMAP plots of single-cell RNA-sequencing analysis.
View article: Supplementary Table S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Table S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Table S2
View article: Supplementary Figure S12 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S12 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S12. EML4-ALK activates the RAS/MAPK/AP-1 signaling pathway.
View article: Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S3. Method to generate macrophages and the phenotype of the macrophages.
View article: Supplementary Figure S8 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S8 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S8. Gating strategies for mouse immune cell types.
View article: Supplementary Figure S5 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S5 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S5.MDSC-abundant TME in fusion gene-positive LUAD.
View article: Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S6. The strategy of MDSC induction by cancer cells.
View article: Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S9. Immunohistochemical (IHC) staining of PD-1+ and PD-L1+ cells, and macrophages in the tumor.
View article: Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S7. The suppressive activity of induced MDSC.
View article: Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
SupplementaryFigureS4.TheexpressionofdendriticcellmarkersandCD8+Tcell-attractantchemokines in macrophages induced by GM-CSF.
View article: Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer
Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer Open
Supplementary Figure S1. Gating strategies for human immune cell types.
View article: Tumor Cell Proportion Assessment in Advanced Non-Squamous Non-Small Cell Lung Cancer Tissue Samples in Real-World Settings in Japan: The ASTRAL Study
Tumor Cell Proportion Assessment in Advanced Non-Squamous Non-Small Cell Lung Cancer Tissue Samples in Real-World Settings in Japan: The ASTRAL Study Open
Background/Objectives: Identification of driver gene alterations helps determine first-line treatment for non-squamous non-small cell lung cancer (NSCLC). Precise assessment of tumor cell proportion is critical for accurate detection of ge…
View article: Corrigendum to “A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers” [Lung Cancer 199 (2025) 108060]
Corrigendum to “A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers” [Lung Cancer 199 (2025) 108060] Open
The authors wish to inform the readers that the correct authors list and affiliations of all the authors have been updated as above. The authors have identified an error in the legend of Figure 5. The legend should be replaced with “Figure…
View article: Schlafen 11 Expression in Patients With Small Cell Lung Cancer and Its Association With Clinical Outcomes
Schlafen 11 Expression in Patients With Small Cell Lung Cancer and Its Association With Clinical Outcomes Open
Background Schlafen 11 (SLFN‐11) has been identified as a sensitizer of tumor cells to DNA‐damaging agents. However, the relationship between SLFN‐11 expression and clinical outcomes in patients with small cell lung cancer (SCLC) remains u…
View article: A Case of T1bN0 Esophageal Squamous Cell Carcinoma That Developed Recurrence 7 Years after Curative Esophagectomy
A Case of T1bN0 Esophageal Squamous Cell Carcinoma That Developed Recurrence 7 Years after Curative Esophagectomy Open
Although several cases of late recurrence (>5 years) have been previously reported, most have a deeper infiltration depth than that of T2 or pathologically positive lymph nodes. However, patients with lymphatic/vascular involvement, even t…
View article: A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers
A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers Open
The modified classification demonstrates essentially higher reproducibility compared to the current WHO classification in NMA. The modified classification proves valuable in identifying low-risk lesions that are entirely non-invasive, and …
View article: Author Correction: Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer
Author Correction: Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer Open
View article: Survival Impacts of Mitochondrial Status in Esophageal Squamous Cell Carcinoma Patients
Survival Impacts of Mitochondrial Status in Esophageal Squamous Cell Carcinoma Patients Open
View article: Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates
Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates Open
The development of next-generation sequencing (NGS) has enabled the discovery of cancer-specific driver gene alternations, making precision medicine possible. However, accurate genetic testing requires a sufficient amount of tumor cells in…
View article: Impacts of tumor microenvironment during neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma
Impacts of tumor microenvironment during neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma Open
With the advent of immune checkpoint inhibitors (ICIs), a better understanding of tumor microenvironment (TME) is becoming crucial in managing esophageal squamous cell carcinoma (ESCC) patients. We investigated the survival impact of TME s…
View article: An algorithm-based technique for counting mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections
An algorithm-based technique for counting mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections Open
View article: Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments
Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments Open
Overcoming resistance to immune checkpoint inhibitors is an important issue in patients with non‐small‐cell lung cancer (NSCLC). Transcriptome analysis shows that adenocarcinoma can be divided into three molecular subtypes: terminal respir…
View article: A Case of Intravascular Large B-cell Lymphoma Within a Glomus Tumor
A Case of Intravascular Large B-cell Lymphoma Within a Glomus Tumor Open
血管内リンパ腫(IVL)は節外リンパ増殖性疾患の稀なサブタイプである.非常に稀であるが,固形腫瘍内にIVLを認める例が報告されている.今回,我々はグロムス腫瘍内にIVLを認めた1例を経験したので報告する.
View article: Machine-based counting of mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections
Machine-based counting of mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections Open
Purpose Visualizing mitochondria in cancer cells from human pathological specimens may improve our understanding of cancer biology. However, using immunohistochemistry to evaluate mitochondria remains difficult because almost all cells con…
View article: Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer
Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer Open
Inflammatory factors in the peripheral blood, such as the C-reactive protein level and neutrophil-to-lymphocyte ratio (NLR), are prognostic markers in multiple types of cancer, including non-small cell lung cancer (NSCLC). However, the ass…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…