Noriko Yamanaka
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View article: Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia
Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia Open
View article: Mass Acorn Poisoning of Japanese Black Breeding Cattle
Mass Acorn Poisoning of Japanese Black Breeding Cattle Open
2019年10月，肉用牛飼養施設において，黒毛和種繁殖雌牛10頭が元気消失，食欲低下及び下痢等の症状を呈し，その後約3週間で9頭が死亡した．血清生化学検査でBUNとCreが高度に上昇，腎臓の病理組織学的検査を実施した5頭全頭で急性尿細管壊死が認められた．放牧場の糞便及び死亡牛の第一胃内容物中からクヌギのドングリの果皮が見つかった．比色法により定量したところ，クヌギドングリには6.08％（乾燥重量％）と高濃度の総ポリフェノールが含まれていた．また，第一胃内容の検査を実施した死…
View article: Simple Method for Extracting Total Polyphenol in Acorns for Diagnosis of Acorn Poisoning
Simple Method for Extracting Total Polyphenol in Acorns for Diagnosis of Acorn Poisoning Open
ドングリによる中毒の診断に資するために，ドングリに含まれる総ポリフェノール（TPPs）の簡便，迅速な抽出手法を開発した．含水アセトンで振盪する本手法は高速溶媒抽出法（ASE）に匹敵する回収率であった上，再現性が高く，簡易であり，十分診断に応用できるものと考えられた．また，この手法でマテバシイのドングリのTPPs濃度を定量したところ，未熟果は熟果よりも有意に濃度が高かった．
View article: Recent Topics and Studies on Bovine Rumen Sensors and Microbiota
Recent Topics and Studies on Bovine Rumen Sensors and Microbiota Open
View article: Development of an analytical method for fumonisin B<sub>1</sub> in porcine tissues and body fluids using UHPLC-MS/MS
Development of an analytical method for fumonisin B<sub>1</sub> in porcine tissues and body fluids using UHPLC-MS/MS Open
High-precision analytical methods to detect fumonisin B1 (FB1) in a limited range of biological samples have recently been reported. Here an analytical method for FB1 for use in a wider range of tissue and body fluid samples, such as the p…
View article: Chronic pancreatitis in farmed pigs fed excessive zinc oxide
Chronic pancreatitis in farmed pigs fed excessive zinc oxide Open
Most of the pigs on a farm in Aichi Prefecture, Japan had chronic diarrhea and severe wasting. The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size…
View article: Sporadic Copper Poisoning of Japanese Black Beef Calves During the Weaning Period
Sporadic Copper Poisoning of Japanese Black Beef Calves During the Weaning Period Open
黄疸，血色素尿を伴う離乳期の黒毛和種子牛の死亡例が数年間にわたって散発している農場があり，病態から銅中毒が疑われた．この農場では，複数の飼料を組み合わせて給餌しており，飼料の銅濃度測定の結果，ほとんどの飼料に銅が含まれていた．子牛給餌飼料中の銅濃度は，飼育全期間を通じて日本飼養標準・肉用牛に示された要求量を超えていた．同農場で飼育されている子牛の血中銅濃度を測定したところ，群全体の血中銅濃度は月齢が進むにつれて上昇しており，持続的な銅の過給が推察された．発症例の血清，死亡例…
View article: Moldy Sweet Potato Toxicity in Japanese Black Breeding Cows
Moldy Sweet Potato Toxicity in Japanese Black Breeding Cows Open
黒毛和種牛繁殖農場で，妊娠牛約25頭の群にサツマイモを3カ月給与したところ，3頭が急死し，他の6頭が呼吸器症状と皮下気腫を呈して死亡した．発症牛では，死亡前に血清AST及びγ-GTPの上昇が認められ，軽度の肝障害が示唆された．死亡牛では，肉眼的に肺の退縮不全，気腫及び水腫，肝臓表面の出血斑が認められた．組織学的に肺胞腔内へのマクロファージ及び好中球の著しい浸潤，Ⅱ型肺胞上皮細胞の増殖，間質性肺気腫及び限局的な肝細胞壊死が認められた．給与サツマイモではカビの発生や黒変などが認…
View article: Changes in hepato-renal gene expression in microminipigs following a single exposure to a mixture of perfluoroalkyl acids
Changes in hepato-renal gene expression in microminipigs following a single exposure to a mixture of perfluoroalkyl acids Open
It is evident that some perfluoroalkyl acids (PFAAs), a group of globally dispersed pollutants, have long biological half-lives in humans and farm animals. However, the effects of PFAAs in domestic animals have not been fully elucidated. T…
View article: Source-Related Effects of Wastewater on Transcription Factor (AhR, CAR and PXR)-Mediated Induction of Gene Expression in Cultured Rat Hepatocytes and Their Association with the Prevalence of Antimicrobial-Resistant Escherichia coli
Source-Related Effects of Wastewater on Transcription Factor (AhR, CAR and PXR)-Mediated Induction of Gene Expression in Cultured Rat Hepatocytes and Their Association with the Prevalence of Antimicrobial-Resistant Escherichia coli Open
Extracts of wastewater collected from 4 sewage treatment plants (STPs) receiving effluents from different sources in South India were investigated for their levels of transcription factor-mediated gene induction in primary cultured rat hep…
View article: Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids
Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids Open
In this study, we evaluated the efficacy of a novel minipig strain, the Microminipig (MMPig), as an animal model for studying the pharmacokinetics of a mixture of 10 perfluoroalkyl acids (PFAAs). After a single oral dose was given, we foun…