Noriyuki Azuma
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View article: Plain-language commentary: 2-year findings from the FIREFLEYE next study looking at how well aflibercept injected into affected eyes in babies with retinopathy of prematurity works and how safe it is compared with laser treatment
Plain-language commentary: 2-year findings from the FIREFLEYE next study looking at how well aflibercept injected into affected eyes in babies with retinopathy of prematurity works and how safe it is compared with laser treatment Open
View article: Impact of prolonged digital device use on acquired comitant esotropia: ACE-DD study 2
Impact of prolonged digital device use on acquired comitant esotropia: ACE-DD study 2 Open
Purpose To investigate changes in strabismus angles in children and young adult patients with recent onset of constant acquired comitant esotropia (ACE) following instructions on hand-held digital devices (DD). Study design Prospective mul…
View article: Sonic Hedgehog Determines Early Retinal Development and Adjusts Eyeball Architecture
Sonic Hedgehog Determines Early Retinal Development and Adjusts Eyeball Architecture Open
The eye primordium of vertebrates initially forms exactly at the side of the head. Later, the eyeball architecture is tuned to see ahead with better visual acuity, but its molecular basis is unknown. The position of both eyes in the face a…
View article: Factors affecting outcome of acquired comitant esotropia with restricted use of digital devices: ACEDD Study 3
Factors affecting outcome of acquired comitant esotropia with restricted use of digital devices: ACEDD Study 3 Open
Objective The objective of this study is to investigate factors associated with outcomes after 3 months of instructed usage of hand-held digital devices (DD) in patients with acquired comitant esotropia (ACE). Methods and analysis This pro…
View article: Outcomes of five cases of retinoblastoma with optic nerve invasion on imaging
Outcomes of five cases of retinoblastoma with optic nerve invasion on imaging Open
Purpose To investigate the timing of enucleation, treatment course, and outcome for retinoblastoma (RB) with optic nerve (ON) invasion on imaging. Study design Retrospective clinical study. Methods Of the 160 patients with RB who presented…
View article: Intravitreal Aflibercept vs Laser Therapy for Retinopathy of Prematurity
Intravitreal Aflibercept vs Laser Therapy for Retinopathy of Prematurity Open
Importance Prospective long-term data after retinopathy of prematurity (ROP) treatment with anti–vascular endothelial growth factor injections vs laser therapy are scarce. The FIREFLEYE (Aflibercept for ROP IVT Injection vs Laser Therapy) …
View article: Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry
Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry Open
View article: Retinal hemorrhages and damages from tractional forces associated with infantile abusive head trauma evaluated by wide-field fundus photography
Retinal hemorrhages and damages from tractional forces associated with infantile abusive head trauma evaluated by wide-field fundus photography Open
View article: Correction: Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study
Correction: Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study Open
View article: Modeling of Retina and Optic Nerve Ischemia–Reperfusion Injury through Hypoxia–Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion Cells
Modeling of Retina and Optic Nerve Ischemia–Reperfusion Injury through Hypoxia–Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion Cells Open
Retinal ganglion cells (RGCs) are specialized projection neurons that constitute part of the retina, and the death of RGCs causes various eye diseases, but the mechanism of RGC death is still unclear. Here, we induced cell death in human i…
View article: Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study
Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study Open
View article: Establishment and visual analysis of CBA/J-<i>Pde6b<sup>Y347Y/Y347X</sup></i> and C3H/HeJ-<i>Pde6b<sup>Y347Y/Y347X</sup></i> mice
Establishment and visual analysis of CBA/J-<i>Pde6b<sup>Y347Y/Y347X</sup></i> and C3H/HeJ-<i>Pde6b<sup>Y347Y/Y347X</sup></i> mice Open
In CBA/J and C3H/HeJ mice, retinitis pigmentosa is inherited as an autosomal-recessive trait due to a mutation in Pde6b, which encodes cGMP phosphodiesterase subunit b. In these strains, the Y347X mutation in Pde6b leads to the upregulatio…
View article: CHOROIDAL NEOVASCULARIZATION IN A CHILD WITH DOWN SYNDROME
CHOROIDAL NEOVASCULARIZATION IN A CHILD WITH DOWN SYNDROME Open
Purpose: The aim of this study was to report a case of Down syndrome with myopic choroidal neovascularization (CNV) and the treatment outcome. Methods: Case report : Main outcome measures include refractive error, fundus examination, optic…
View article: The Structural Abnormalities Are Deeply Involved in the Cause of RPGRIP1-Related Retinal Dystrophy in Japanese Patients
The Structural Abnormalities Are Deeply Involved in the Cause of RPGRIP1-Related Retinal Dystrophy in Japanese Patients Open
Leber congenital amaurosis (LCA) is the most severe form of inherited retinal dystrophy. RPGRIP1-related LCA accounts for 5–6% of LCA. We performed whole-exome sequencing and whole-genome sequencing (WGS) on 29 patients with clinically sus…
View article: A pediatric case of congenital stromal corneal dystrophy caused by the novel variant c.953del of the DCN gene
A pediatric case of congenital stromal corneal dystrophy caused by the novel variant c.953del of the DCN gene Open
View article: Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity
Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity Open
ClinicalTrials.gov Identifier: NCT04004208.
View article: Integrator complex subunit 15 controls mRNA splicing and is critical for eye development
Integrator complex subunit 15 controls mRNA splicing and is critical for eye development Open
The eye and brain are composed of elaborately organized tissues, development of which is supported by spatiotemporally precise expression of a number of transcription factors and developmental regulators. Here we report the molecular and g…
View article: Maternal Uniparental Isodisomy of Chromosome 4 and 8 in Patients with Retinal Dystrophy: SRD5A3-Congenital Disorders of Glycosylation and RP1-Related Retinitis Pigmentosa
Maternal Uniparental Isodisomy of Chromosome 4 and 8 in Patients with Retinal Dystrophy: SRD5A3-Congenital Disorders of Glycosylation and RP1-Related Retinitis Pigmentosa Open
Purpose: Uniparental disomy (UPD) is a rare chromosomal abnormality. We performed whole-exosome sequencing (WES) in cases of early-onset retinal dystrophy and identified two cases likely caused by UPD. Herein, we report these two cases and…
View article: Biallelic CDK9 variants as a cause of a new multiple-malformation syndrome with retinal dystrophy mimicking the CHARGE syndrome
Biallelic CDK9 variants as a cause of a new multiple-malformation syndrome with retinal dystrophy mimicking the CHARGE syndrome Open
View article: Correction to: Analysis of IKBKG/NEMO gene in five Japanese cases of incontinentia pigmenti with retinopathy: fine genomic assay of a rare male case with mosaicism
Correction to: Analysis of IKBKG/NEMO gene in five Japanese cases of incontinentia pigmenti with retinopathy: fine genomic assay of a rare male case with mosaicism Open
View article: RARE-16. SEVEN CASES OF RETINOBLASTOMA WITH CNS INVOLVEMENTS
RARE-16. SEVEN CASES OF RETINOBLASTOMA WITH CNS INVOLVEMENTS Open
Treatment strategy for trilateral retinoblastoma (TRb: very rare RB with brain tumor) or retinoblastoma with central nervous system (CNS) involvement is not established yet. We retrospectively reviewed our seven cases of these rare almost …
View article: PEDT-04 SIX CASES OF RETINOBLASTOMA WITH CNS INVOLVEMENT
PEDT-04 SIX CASES OF RETINOBLASTOMA WITH CNS INVOLVEMENT Open
Although the survival rate of intraocular retinoblastoma (RB) is nearly 100%, the outcome of central nervous system (CNS) involvement or Trilateral retinoblastoma (TRb: very rare RB which associated with brain tumor) is dismal. We retrospe…
View article: Retinal structure in Leber’s congenital amaurosis caused by RPGRIP1 mutations
Retinal structure in Leber’s congenital amaurosis caused by RPGRIP1 mutations Open
This study aimed to evaluate retinal structure in the early stage of Leber’s congenital amaurosis (LCA) caused by RPGRIP1 mutations. Four patients from two families were included. Case 1 was a 13-year-old girl, cases 2 and 3 were 7-year-ol…
View article: X-linked Retinitis Pigmentosa in Japan: Clinical and Genetic Findings in Male Patients and Female Carriers
X-linked Retinitis Pigmentosa in Japan: Clinical and Genetic Findings in Male Patients and Female Carriers Open
X-linked retinitis pigmentosa (XLRP) is a type of severe retinal dystrophy, and female carriers of XLRP demonstrate markedly variable clinical severity. In this study, we aimed to elucidate the clinical findings of male patients with and f…
View article: The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish
The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish Open
View article: Spot™ Vision Screener for Small Children With Ocular Diseases
Spot™ Vision Screener for Small Children With Ocular Diseases Open
【目的】眼器質疾患をもつ低年齢児に対しSpot™ Vision Screener（以下SVS）を施行し、検査の有用性を検討した。
View article: Optical coherence tomography and video recording of a case of bilateral contractile peripapillary staphyloma
Optical coherence tomography and video recording of a case of bilateral contractile peripapillary staphyloma Open
In a patient with bilateral CPS, we observed unsynchronized contraction between the eyes and the presence of sequential hyperreflective tissue under the sclera using bilateral ophthalmic approaches.
View article: Mutation Analysis of Japanese Patients with Leber Congenital Amaurosis by Next Generation Sequencing
Mutation Analysis of Japanese Patients with Leber Congenital Amaurosis by Next Generation Sequencing Open
View article: Differentiation of human iPSC-derived optic vesicles into numerous types of retinal cells
Differentiation of human iPSC-derived optic vesicles into numerous types of retinal cells Open
View article: Molecular Diagnosis of 34 Japanese Families with Leber Congenital Amaurosis Using Targeted Next Generation Sequencing
Molecular Diagnosis of 34 Japanese Families with Leber Congenital Amaurosis Using Targeted Next Generation Sequencing Open