Norlinah Mohamed Ibrahim
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View article: Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis
Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis Open
View article: The <i>LRRK2</i> p.A419V variant associates with risk of Parkinson’s disease in the East Asian population and an evaluation on age of onset
The <i>LRRK2</i> p.A419V variant associates with risk of Parkinson’s disease in the East Asian population and an evaluation on age of onset Open
Common and rare variants in LRRK2 influence Parkinson’s disease (PD) risk across diverse populations. We investigated the p.A419V variant across multiple ancestry cohorts comprising over 200,000 individuals. In cases of East Asian ancestry…
View article: Etiological patterns and risk factors for poor outcomes following lower limb amputation in Uganda: A multicenter study
Etiological patterns and risk factors for poor outcomes following lower limb amputation in Uganda: A multicenter study Open
Background Lower limb amputations are a common procedure performed. The etiological patterns, outcomes of the amputation surgeries as well as the risk factors for these outcomes are not well documented in Uganda, with the only recent study…
View article: Exercise Habits in People with Parkinson's: A Multinational Survey
Exercise Habits in People with Parkinson's: A Multinational Survey Open
Background Exercise has been demonstrated to result in improvements in physical function, cognition, and quality of life in People with Parkinson's (PwP) but its adoption is variable. Objectives To investigate exercise preferences, levels,…
View article: Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide
Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide Open
Insulin and toll-like receptor 4 interaction in the rat model of Parkinson's disease induced by lipopolysaccharide
View article: Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson’s Disease
Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson’s Disease Open
Background: Insulin resistance is an important pathological hallmark of Parkinson’s disease (PD). Proinflammatory cytokines during neuroinflammation decrease insulin sensitivity by suppressing insulin signaling elements. Toll-like receptor…
View article: Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers Open
View article: CD8+ aggressive T-cell lymphoma (T-NHL) involving the liver and skin: a case study
CD8+ aggressive T-cell lymphoma (T-NHL) involving the liver and skin: a case study Open
Introduction/Objective Aggressive T-NHL involving cutaneous and visceral organs is rare. We report a case with a complex presentation that was found to have hepatic and skin lesions simultaneously. We emphasize the importance of the clinic…
View article: Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission
Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission Open
View article: Stroke Riskometer Application (SRA™) influence on lifestyle changes of home bound familial Malaysian stroke caregivers: a randomised controlled trial in a primary care based longer term stroke care facility
Stroke Riskometer Application (SRA™) influence on lifestyle changes of home bound familial Malaysian stroke caregivers: a randomised controlled trial in a primary care based longer term stroke care facility Open
View article: Automated Gait Analysis Based on a Marker-Free Pose Estimation Model
Automated Gait Analysis Based on a Marker-Free Pose Estimation Model Open
Gait analysis is an essential tool for detecting biomechanical irregularities, designing personalized rehabilitation plans, and enhancing athletic performance. Currently, gait assessment depends on either visual observation, which lacks co…
View article: The multifaceted impact of structured training program on persons with Parkinson disease and their adult caregiver: A protocol for a systematic review
The multifaceted impact of structured training program on persons with Parkinson disease and their adult caregiver: A protocol for a systematic review Open
Background: Training caregivers and persons with Parkinson Disease (PwPD) is crucial to provide them with adequate knowledge and care skills in preparation for the Parkinson disease (PD) progression. This review will systematically evaluat…
View article: Nine Hereditary Movement Disorders First Described in Asia: Their History and Evolution
Nine Hereditary Movement Disorders First Described in Asia: Their History and Evolution Open
Clinical case studies and reporting are important to the discovery of new disorders and the advancement of medical sciences. Both clinicians and basic scientists play equally important roles leading to treatment discoveries for both cures …
View article: Historical and More Common Nongenetic Movement Disorders From Asia
Historical and More Common Nongenetic Movement Disorders From Asia Open
Nongenetic movement disorders are common throughout the world. The movement disorders encountered may vary depending on the prevalence of certain disorders across various geographical regions. In this paper, we review historical and more c…
View article: Issue Information
Issue Information Open
Movement Disorders Clinical Practice-is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/…
View article: Genetic Movement Disorders Commonly Seen in Asians
Genetic Movement Disorders Commonly Seen in Asians Open
The increasing availability of molecular genetic testing has changed the landscape of both genetic research and clinical practice. Not only is the pace of discovery of novel disease‐causing genes accelerating but also the phenotypic spectr…
View article: Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide
Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide Open
Toll-like receptor (TLR) 4 is involved in neuroinflammatory processes – both in peripheral tissues and the central nervous system. Pro-inflammatory cytokines production due to over activation of TLR4 interfere with insulin signaling elemen…
View article: Causes, factors, and complications associated with hospital admissions among patients with Parkinson's disease
Causes, factors, and complications associated with hospital admissions among patients with Parkinson's disease Open
Introduction Patients with Parkinson's disease (PD) are at a higher risk of hospital admissions compared to the general population. We studied the causes and factors associated with admissions among patients with PD over 6 years. Methods W…
View article: A KMT2B Frameshift Variant Causing Focal Dystonia Restricted to the Oromandibular Region After Long-Term Follow-up
A KMT2B Frameshift Variant Causing Focal Dystonia Restricted to the Oromandibular Region After Long-Term Follow-up Open
KMT2B-linked dystonia (DYT-KMT2B) is a childhood-onset dystonia syndrome typically beginning in the lower limbs and progressing caudocranially to affect the upper limbs with eventual prominent craniocervical involvement. Desp…
View article: Editorial: Genetic and molecular diversity in Parkinson's disease
Editorial: Genetic and molecular diversity in Parkinson's disease Open
EDITORIAL article Front. Aging Neurosci., 16 December 2022Sec. Parkinson’s Disease and Aging-related Movement Disorders Volume 14 - 2022 | https://doi.org/10.3389/fnagi.2022.1094914
View article: Neurological manifestations in <scp>SARS‐CoV</scp>‐2 infection: A single‐center cross‐sectional study in Malaysia
Neurological manifestations in <span>SARS‐CoV</span>‐2 infection: A single‐center cross‐sectional study in Malaysia Open
Background Neurological involvement associated with SARS‐CoV‐2 infection has been reported from different regions of the world. However, data from South East Asia are scarce. We described the neurological manifestations and their associate…
View article: Movement Disorders Resulting From Bilateral Basal Ganglia Lesions in End-Stage Kidney Disease: A Systematic Review
Movement Disorders Resulting From Bilateral Basal Ganglia Lesions in End-Stage Kidney Disease: A Systematic Review Open
Objective The basal ganglia (BG) are susceptible to fluctuations in blood urea levels, sometimes resulting in movement disorders. We described patients with end-stage kidney disease (ESKD) presenting with movement disorders associated with…
View article: Labrune’s Syndrome Presenting With Stereotypy-Like Movements and Psychosis: A Case Report and Review
Labrune’s Syndrome Presenting With Stereotypy-Like Movements and Psychosis: A Case Report and Review Open
Labrune’s syndrome, or leukoencephalopathy with brain calcifications and cysts (LCC), is a rare genetic syndrome with variable neurological presentations. Psychiatric manifestations and involuntary movements are uncommonly reported. We rep…
View article: Fecal Calprotectin in Parkinson’s Disease and Multiple System Atrophy
Fecal Calprotectin in Parkinson’s Disease and Multiple System Atrophy Open
Objective Converging evidence suggests that intestinal inflammation is involved in the pathogenesis of neurodegenerative diseases. Previous studies on fecal calprotectin in Parkinson’s disease (PD) were limited by small sample sizes, and l…
View article: Spinocerebellar ataxias in Asia: Prevalence, phenotypes and management
Spinocerebellar ataxias in Asia: Prevalence, phenotypes and management Open
This paper reviews and summarizes three main aspects of spinocerebellar ataxias (SCA) in the Asian population. First, epidemiological studies were comprehensively reviewed. Overall, the most common subtypes include SCA1, SCA2, SCA3, and SC…
View article: Aberrant Neurogliovascular Unit Dynamics in Cerebral Small Vessel Disease: A Rheological Clue to Vascular Parkinsonism
Aberrant Neurogliovascular Unit Dynamics in Cerebral Small Vessel Disease: A Rheological Clue to Vascular Parkinsonism Open
The distinctive anatomical assemble and functionally discrete multicellular cerebrovasculature dynamics confer varying rheological and blood–brain barrier permeabilities to preserve the integrity of cerebral white matter and its neural mic…
View article: Management of Parkinson’s Disease in the COVID-19 Pandemic and Future Perspectives in the Era of Vaccination
Management of Parkinson’s Disease in the COVID-19 Pandemic and Future Perspectives in the Era of Vaccination Open
The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) has led to a serious global health crisis. Increasing evidence suggests that elderly individuals with underlyin…
View article: The state of stroke services across the globe: Report of World Stroke Organization–World Health Organization surveys
The state of stroke services across the globe: Report of World Stroke Organization–World Health Organization surveys Open
Background Improving stroke services is critical for reducing the global stroke burden. The World Stroke Organization–World Health Organization– Lancet Neurology Commission on Stroke conducted a survey of the status of stroke services in l…
View article: The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment
The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment Open
The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenes…
View article: Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: A randomised controlled trial
Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: A randomised controlled trial Open
Objective We determined the effectiveness of a multi-strain probiotic (Hexbio ® ) containing microbial cell preparation MCP ® BCMC ® on constipation symptoms and gut motility in PD patients with constipation. Methods PD patients with const…