Norma Verdolini
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View article: Impact of Duration of Untreated Bipolar Disorder on Clinical Outcomes: A Systematic Review
Impact of Duration of Untreated Bipolar Disorder on Clinical Outcomes: A Systematic Review Open
Background Bipolar disorder (BD) prognosis is influenced by multiple factors, including age, sex and comorbid conditions. This review focuses on the concept termed ‘duration of untreated bipolar disorder’ (DUB), defined as the interval bet…
View article: Obstetric complications, cortical gyrification, and cognition in first-episode psychosis
Obstetric complications, cortical gyrification, and cognition in first-episode psychosis Open
Background Obstetric complications (OCs) are associated with cognitive and brain abnormalities observed in patients with schizophrenia. Gyrification, a measure of cortical integrity sensitive to events occurring during the prenatal and per…
View article: Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis
Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis Open
Introduction Impairment in both psychosocial functioning and neurocognition (NC) performance is present in bipolar disorder (BD) yet the role of sex differences in these deficits remains unclear. The present systematic review and meta-anal…
View article: Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions Open
Background Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hu…
View article: Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders
Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders Open
This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach's validity. The atlas NIfTI maps are available online.
View article: Sex matters: Differences in prodromes, clinical and neuropsychological features in individuals with a first episode mania or psychosis
Sex matters: Differences in prodromes, clinical and neuropsychological features in individuals with a first episode mania or psychosis Open
The main finding is the presence of significant sex effect and group by sex interaction on specific neurocognitive cognition and emotional intelligence measures. Tailored sex-based early treatment strategies might be implemented.
View article: Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode Open
Prolactin plays a role in the functionality and clinical symptomatology of FEP patients. Our results suggest that pharmacological counselling in patients with hyperprolactinemia at baseline and negative symptomatology might improve their f…
View article: Aerobic capacity and mitochondrial function in bipolar disorder: a longitudinal study during acute phases and after clinical remission
Aerobic capacity and mitochondrial function in bipolar disorder: a longitudinal study during acute phases and after clinical remission Open
Background Aerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. W…
View article: The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis
The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis Open
Background Polygenic risk scores for educational attainment (PRS EA ), cognitive reserve (CR), and clinical symptoms are associated with functioning in first-episode psychosis (FEP). Nevertheless, the mechanisms underlying their complex in…
View article: Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis
Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis Open
Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neu…
View article: Patterns of pharmacotherapy for bipolar disorder: A <scp>GBC</scp> survey
Patterns of pharmacotherapy for bipolar disorder: A <span>GBC</span> survey Open
Objectives To understand treatment practices for bipolar disorders (BD), this study leveraged the Global Bipolar Cohort collaborative network to investigate pharmacotherapeutic treatment patterns in multiple cohorts of well‐characterized i…
View article: Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion <scp>MRI</scp>: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment
Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion <span>MRI</span>: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment Open
Despite diffusion tensor imaging (DTI) evidence for widespread fractional anisotropy ( FA ) reductions in the brain white matter of patients with bipolar disorder, questions remain regarding the specificity and sensitivity of FA abnormalit…
View article: Corrigendum: Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: differences between males and females
Corrigendum: Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: differences between males and females Open
[This corrects the article DOI: 10.3389/fpsyt.2022.982583.].
View article: Exploring Digital Biomarkers of Illness Activity in Mood Episodes: Hypotheses Generating and Model Development Study
Exploring Digital Biomarkers of Illness Activity in Mood Episodes: Hypotheses Generating and Model Development Study Open
Background Depressive and manic episodes within bipolar disorder (BD) and major depressive disorder (MDD) involve altered mood, sleep, and activity, alongside physiological alterations wearables can capture. Objective Firstly, we explored …
View article: Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis
Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis Open
Background Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase psychosis vulnerability independently of genetic risk, in interaction with it, or are a manifestation of psychosi…
View article: Obstetric complications and clinical presentation in first episode of psychosis
Obstetric complications and clinical presentation in first episode of psychosis Open
Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs…
View article: Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.
Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts. Open
Our findings suggest that multi-item instruments provide valuable information on different aspects of suicidal thoughts or behavior but share a modest core factor with single suicidal ideation items. Retrospective, multisite collaborations…
View article: Exploring Digital Biomarkers of Illness Activity in Mood Episodes: Hypotheses Generating and Model Development Study (Preprint)
Exploring Digital Biomarkers of Illness Activity in Mood Episodes: Hypotheses Generating and Model Development Study (Preprint) Open
BACKGROUND Depressive and manic episodes within bipolar disorder (BD) and major depressive disorder (MDD) involve altered mood, sleep, and activity, alongside physiological alterations wearables can capture. OBJECTIVE Firstly, we explor…
View article: Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis
Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis Open
Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, …
View article: Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: differences between males and females
Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: differences between males and females Open
Background Deficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence functionality. Sex d…
View article: Sex Differences in Bipolar Disorders: Impact on Psychopathological Features and Treatment Response
Sex Differences in Bipolar Disorders: Impact on Psychopathological Features and Treatment Response Open
Introduction Sex differences were demonstrated in bipolar disorders (BD) concerning epidemiological, clinical, and psychopathological characteristics, but consensus is lacking. Moreover, data concerning the influence of sex on treatment re…
View article: Can machine learning with data from wearable devices distinguish disease severity levels and generalise across patients? A pilot study in Mania and Depression
Can machine learning with data from wearable devices distinguish disease severity levels and generalise across patients? A pilot study in Mania and Depression Open
A bstract Mood disorders are severe and chronic mental conditions exacting high costs from society. The lack of reliable biomarkers to aid clinicians in tailoring pharmacotherapy based on distinguishable patient-specific traits means that …