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View article: Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis Open
Objectives To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. Design Pooling of longitudinal dat…
View article: Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study
Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study Open
Background Allergic rhinitis (AR) is a major non‐communicable disease that affects the health‐related quality of life (HRQoL) of patients. However, data on HRQoL and symptom control in AR patients with comorbid asthma (AR + asthma) are lac…
View article: Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 1. Table S1: “Summary of the studies in the meta-analysis for the association between Season of Birth and DNA methylation at birth and in children (age: 1 to 11 years)”. Baseline summary of participants from each of the ind…
View article: Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 5. Table S4: “Direction of differential methylation of CpGs in DMRs of the at-birth and childhood analyses (preliminary analysis”).
View article: Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 6. Table S5: “Genes mapped to DMP/DMR identified in at-birth samples of babies born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associatio…
View article: Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 8. Table S8: “Genes mapped to DMR identified in the childhood samples of children born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associa…
View article: Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children Open
Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tra…
View article: Symptom control and health-related quality of life in allergic rhinitis with and without comorbid asthma: a multicentre European study
Symptom control and health-related quality of life in allergic rhinitis with and without comorbid asthma: a multicentre European study Open
Background: Allergic rhinitis (AR) is a major non-communicable disease that affects the health-related quality of life (HRQoL) of patients. AR is significantly related to asthma also affecting HRQoL. However, data on HRQoL and symptom cont…
View article: Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills Open
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausibl…
View article: Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium Open
Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA …
View article: Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills Open
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausibl…
View article: Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium Open
Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA …
View article: Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium Open
Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA …
View article: Additional file 1 of Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Additional file 1 of Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age Open
Table S1. Cohort-specific results from epigenome-wide association analyses of gestational age. Table S2. Normalization technique and phenotype definitions used by each cohort. Table S3. Bonferroni-significant CpGs from the meta-analysis on…
View article: Comparison of Smoking-Related DNA Methylation Between Newborns from Prenatal Exposure and Adults from Personal Smoking
Comparison of Smoking-Related DNA Methylation Between Newborns from Prenatal Exposure and Adults from Personal Smoking Open
Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials &…
View article: Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Epigenome-wide meta-analysis of DNA methylation and childhood asthma Open
Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. OBJECTIVE: We sought to identify differential DNA methylation in …
View article: Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide database
Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide database Open
Allergic rhinitis (AR) is a chronic disease affecting a large amount of the population. To optimize treatment and disease management, it is crucial to detect patients suffering from severe forms. Several tools have been used to classify pa…
View article: Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project
Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project Open
The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of …
View article: Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts Open
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whethe…