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View article: Regulation of Antioxidant Expression in the Liver Tissue of Obese Rats Treated with Coriander Seed Ethanolic Extract: In Silico and In Vivo Studies
Regulation of Antioxidant Expression in the Liver Tissue of Obese Rats Treated with Coriander Seed Ethanolic Extract: In Silico and In Vivo Studies Open
Background/Objectives: Obesity increases reactive oxygen species (ROS), thereby triggering oxidative stress. Coriander seeds contain polyphenolic compounds that act as natural antioxidants to reduce oxidative stress. Coriander seed ethanol…
View article: The Effect of Intermittent Fasting on FOXO3 Expression, Proteasome Activity and Oxidative Stress in Obese Men: A Clinical Trial
The Effect of Intermittent Fasting on FOXO3 Expression, Proteasome Activity and Oxidative Stress in Obese Men: A Clinical Trial Open
Introduction: The escalation of metabolic imbalance in obesity not only diminishes lifespan but also accelerates the cellular and biomolecular mechanisms of aging. This study aimed to explore the effect of intermittent fasting on FOXO3 exp…
View article: Do aerobic and anaerobic exercises differently affect muscle and liver biomarkers in young adult males?
Do aerobic and anaerobic exercises differently affect muscle and liver biomarkers in young adult males? Open
Introduction: Exercise, despite its well-established benefits, can lead to several adverse effects, including muscle injuries and significant elevations in liver enzymes. Objective: This study investigated the effects of aerobic and anaero…
View article: The Correlation Between Zinc Intake and Superoxide Dismutase Activity with Cognitive Function in the Elderly
The Correlation Between Zinc Intake and Superoxide Dismutase Activity with Cognitive Function in the Elderly Open
This study found no significant correlation between zinc intake and cognitive function. However, SOD activity were significantly correlated with cognitive function in the elderly.
View article: The effect of coriander seed extract on reducing triacylglycerol synthesis andlipid droplets in the liver of obese rats induced by high-fat diet
The effect of coriander seed extract on reducing triacylglycerol synthesis andlipid droplets in the liver of obese rats induced by high-fat diet Open
Obesity is a serious health problem that is often caused by consuming a high-fat diet (HFD) and exacerbated by a sedentary lifestyle. Non-alcoholic fatty liver disease (NAFLD), a condition where triacylglycerol (TAG) is accumulated in the …
View article: An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies
An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies Open
Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address …
View article: T Allele of FOXO3 rs2802292 Increases CCL2 Concentration and Slightly Decreases TGF-β Concentration in Indonesian Elderly
T Allele of FOXO3 rs2802292 Increases CCL2 Concentration and Slightly Decreases TGF-β Concentration in Indonesian Elderly Open
Background: Cellular senescence and the senescence-associated secretory phenotype (SASP) are pivotal factors influencing aging and age-related diseases. SASP secretes cytokines, chemokines, metalloproteinases, and growth factors that cause…
View article: Potential Anti-Senescence Effect of Extract from Andrographis paniculata Herbal Plant and Its Bioactive Compounds: A Systematic Review
Potential Anti-Senescence Effect of Extract from Andrographis paniculata Herbal Plant and Its Bioactive Compounds: A Systematic Review Open
The rapid aging of the global population is a major worldwide issue because of the close relationship between age and the development of several diseases. Aging or senescence is among the most widely studied topics at the moment. However, …
View article: Oxidative stress and antioxidant status mong the elderly in Jakarta
Oxidative stress and antioxidant status mong the elderly in Jakarta Open
Background: Indonesia is experiencing a demographic shift, with the elderly population comprising 9.92% (26.82 million) of the total population, 8.21% of whom reside in Jakarta. Oxidative stress is a key contributor to the development of d…
View article: Molecular Insights into Spirulina platensis Compounds Targeting TNFa and P21 in Delaying Cellular Senescence Mechanisms: An In Silico Approach
Molecular Insights into Spirulina platensis Compounds Targeting TNFa and P21 in Delaying Cellular Senescence Mechanisms: An In Silico Approach Open
View article: COMBINING LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LC-MS/MS) TECHNIQUE, SPECTROPHOTOMETERVALIDATION AND AN IN SILICO STUDY OF 96% ETHANOL EXTRACT OF SPIRULINA PLATENSIS
COMBINING LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LC-MS/MS) TECHNIQUE, SPECTROPHOTOMETERVALIDATION AND AN IN SILICO STUDY OF 96% ETHANOL EXTRACT OF SPIRULINA PLATENSIS Open
Objective: This study was to analyze the component sofa 96% ethanol extract of Spirulina platensis by the LC-MS/MS technique, then validate them with the spectrophotometer technique using the C-phycocyanin standard and an in silico study a…
View article: Andrographis paniculata Ethanol Extract Alleviates High Glucose-induced Senescence of Human Umbilical Vein Endothelial Cells via the Regulation of mTOR and SIRT1 Pathways
Andrographis paniculata Ethanol Extract Alleviates High Glucose-induced Senescence of Human Umbilical Vein Endothelial Cells via the Regulation of mTOR and SIRT1 Pathways Open
BACKGROUND: Chronic exposure of high glucose (HG) in endothelial cell induces senescence which may contribute to the development and progression of age-related diseases including insulin resistance. Andrographis paniculata improves insulin…
View article: Identification of cardiac premature senescence markers through GEO database interaction approach
Identification of cardiac premature senescence markers through GEO database interaction approach Open
Background: Cardiomyocytes are cardiac muscle cells where premature senescence can occur. The availability of in silico research regarding premature senescence in cardiomyocytes is still limited. Purpose: This in silico research aims to id…
View article: The effect of ethanol-based coriander (Coriandrum sativum L.) seed extract on oxidative stress, antioxidant level and cellular senescence in the heart of obese rat
The effect of ethanol-based coriander (Coriandrum sativum L.) seed extract on oxidative stress, antioxidant level and cellular senescence in the heart of obese rat Open
Context: High-fat diets contribute to oxidative stress and trigger cellular senescence through an imbalance in reactive oxygen species. The potential of coriander (Coriandrum sativum) seed, known for its therapeutic properties against oxid…
View article: IRON INTAKE, HEMOGLOBIN LEVEL AND ITS ASSOCIATION WITH KARNOFSKY SCORE: A CROSS SECTIONAL STUDY IN PULMONARY TUBERCULOSIS PATIENTS OF RSUP PERSAHABATAN
IRON INTAKE, HEMOGLOBIN LEVEL AND ITS ASSOCIATION WITH KARNOFSKY SCORE: A CROSS SECTIONAL STUDY IN PULMONARY TUBERCULOSIS PATIENTS OF RSUP PERSAHABATAN Open
Endometriosis is a chronic gynecological disease that often causes chronic pain, dysmenorrhea, and infertility. Hormonal treatment as definitive therapy for endometriosis can disrupt and lead to recurrent pain. Flavonoids are natural bioac…
View article: Freediving, Hypoxia, and Inflammation: Physiological Adaptations and Interactions between HIF and NF-κB
Freediving, Hypoxia, and Inflammation: Physiological Adaptations and Interactions between HIF and NF-κB Open
Freediving presents a unique set of physiological challenges and adaptations, making it a subject of interest for researchers studying the effects of extreme environmental conditions on the human body. There is a complex interplay between …
View article: Polymorphism of the Forkhead box-O3 (FOXO3) Longevity Gene rs2802292 and senescence-associated secretory phenotype (SASP) in Indonesian Elderly Population
Polymorphism of the Forkhead box-O3 (FOXO3) Longevity Gene rs2802292 and senescence-associated secretory phenotype (SASP) in Indonesian Elderly Population Open
BACKGROUND: Forkhead box O3 (FOXO3) is a transcription factor that regulates stress resistance, metabolism, cell cycle, and apoptosis. Several studies exhibited the association of the FOXO3 polymorphism rs2802292 with human longevity and p…
View article: Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats Open
In this study, the potential neuroprotective ability of coriander seeds ( Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how…
View article: Effect of Calorie Restriction on the Expression of Sirtuin1 as an Antiaging Biomarker
Effect of Calorie Restriction on the Expression of Sirtuin1 as an Antiaging Biomarker Open
Calorie restriction (CR) is the most effective method for delaying aging and preventing the onset of age-related diseases. Sirtuins constitute a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases. Their activi…
View article: The effect of intermittent fasting 5:2 on IL-6 levels in obese male employees in Jakarta
The effect of intermittent fasting 5:2 on IL-6 levels in obese male employees in Jakarta Open
Background: Obesity is a condition of excessive fat accumulation in adipose tissue. This condition causes endothelial damage, increase macrophage infiltration, and inflammation in adipose tissue. Inflammation happens due to the increase of…
View article: High concentration of γ‑H2AX correlates with a marker of apoptotic suppression and PI3K/Akt pathway upregulation in glioblastoma multiforme
High concentration of γ‑H2AX correlates with a marker of apoptotic suppression and PI3K/Akt pathway upregulation in glioblastoma multiforme Open
Glioblastoma multiforme (GBM) is a very aggressive type of primary brain tumor in adults with a poor prognosis. DNA double-strand breaks are known to be associated with the development of numerous cancer types due to their ability to gener…
View article: Effects of fasting on FOXO3 expression as an anti-aging biomarker in the liver
Effects of fasting on FOXO3 expression as an anti-aging biomarker in the liver Open
Intermittent fasting significantly increased the FOXO3 and SIRT1 mRNA expressions and the SOD activity level in the livers of the rabbits and significantly decreased the circulating and hepatic IGF-1. Therefore, interm…
View article: The impact of fasting toward oxidative stress marker in the liver and plasma of new zealand white rabbit
The impact of fasting toward oxidative stress marker in the liver and plasma of new zealand white rabbit Open
Background: Fasting may increase the activity of endogenous antioxidants and protect against oxidative stress. However, the effects of different fasting durations on the liver have not been reported. Objective: The purpose of this study is…
View article: The Effect of Fasting on Oxidative Stress in the Vital Organs of New Zealand White Rabbit.
The Effect of Fasting on Oxidative Stress in the Vital Organs of New Zealand White Rabbit. Open
The effect of fasting on oxidative stress in various organs showed various responses, however fasting reduced oxidative stress based on MDA and GSH levels in the heart and brain, respectively.
View article: Development and preliminary validity of an Indonesian mobile application for a balanced and sustainable diet for obesity management
Development and preliminary validity of an Indonesian mobile application for a balanced and sustainable diet for obesity management Open
View article: Diet Quality Profile among Urban Elderly in Jakarta during COVID-19 Pandemic in Indonesia
Diet Quality Profile among Urban Elderly in Jakarta during COVID-19 Pandemic in Indonesia Open
Background: Insulin resistance is a condition in which insulin cannot take up glucose, increasing blood glucose. Elderly people are more exposed to insulin resistance, requiring dietary interventions that extend longevity. Trehalose, a nat…
View article: Relationship between iron intake and iron status to stunted in children aged 24-35 months during the COVID-19 pandemic in Jakarta
Relationship between iron intake and iron status to stunted in children aged 24-35 months during the COVID-19 pandemic in Jakarta Open
Covid 19 pandemic has caused changes in the socioeconomic conditions, affects parents' ability to sustain their children nutritious food. If nutrients are insufficient for a long term is causing growth to be stunted.
View article: The impact of dietary restrictions on the expression of FOXO3 as an anti-ageing biomarker
The impact of dietary restrictions on the expression of FOXO3 as an anti-ageing biomarker Open
Ageing involves destruction on the molecular, cellular, and organ level, causing disease and death. Previous research has discovered that both diet and genetics can affect ageing. Forkhead helix box (FOXO) transcription factors are found t…
View article: Flavonoid intake and its correlation to malondialdehyde serum among reproductive-aged women with obesity
Flavonoid intake and its correlation to malondialdehyde serum among reproductive-aged women with obesity Open
Background: Obesity modulates oxidative stress and can be detected by examining malondialdehyde (MDA) serum levels. Flavonoids are natural bioactive ingredients that can be found in various types of vegetables and fruits that function as a…
View article: Correlation of zinc intake with hair zinc levels and appetite in children aged 2-3 years in Jakarta
Correlation of zinc intake with hair zinc levels and appetite in children aged 2-3 years in Jakarta Open
Background: Children under five years experience rapid growth and development, so that adequate nutritional intake is very important. Zinc is essential for child development and growth. Children’s zinc requirements are fulfilled from daily…