Explanipedia

Advancing Heart Failure Care: Breakthroughs and Emerging Strategies Open

Andrea Tedeschi, Federico Barocelli, Luigi Gerra, F Breviario, Matteo Palazzini , et al. · 2025

Heart failure represents a complex clinical syndrome characterized by progressive ventricular dysfunction, systemic congestion, and high mortality despite significant advances in pharmacological and device-based therapy. This review explor…

WITHDRAWN: The ALTSHOCK criteria for respiratory failure in cardiogenic shock Open

Guido Tavazzi, Andrea Montisci, Giulia Maj, Giovanni Tavecchia, Simone Frea , et al. · 2025

Withdrawal Statement The authors have withdrawn their manuscript because the submission was unintended and accidental, and therefore was not meant to enter the public record in its current form. Moreover, the analyses underlying the manusc…

Pre‐admission beta‐blocker therapy and outcomes in cardiogenic shock: Insights from the Altshock‐2 Registry Open

Matteo Pagnesi, Mauro Riccardi, Alice Sacco, Giovanni Tavecchia, Giovanna Viola , et al. · 2025

Aims We aimed to assess the impact of pre‐admission beta‐blocker (BB) therapy on the clinical characteristics, in‐hospital treatment and outcomes of patients with cardiogenic shock (CS). Methods All patients enrolled in the multicentre pro…

Lung ultrasound and mortality in a cardiogenic shock population: A prospective registry‐based analysis Open

Guido Tavazzi, Costanza Natalia Julia Colombo, Matteo Pagnesi, Maurizio Bertaina, Andrea Montisci , et al. · 2025

Aims Lung ultrasound (LUS) is a widely used technique to assess de‐aeration in critically ill patients with respiratory failure. There is paucity of data on LUS in cardiogenic shock (CS). We sought to evaluate the epidemiology of lung cong…

Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study Open

Jonas Sundermeyer, Caroline Kellner, Benedikt N. Beer, Lisa Besch, Angela Dettling , et al. · 2025

Aims Heart failure–related cardiogenic shock (HF‐CS) accounts for about half of CS cases, with a paucity of data regarding the role of kidney injury in this subset. This study aims to evaluate patient characteristics and outcome associated…

Prevention of readmission in the acute setting for heart failure patients: an adapted protocol of levosimendan infusion in inpatient high-intensity cardiac rehabilitation Open

Ignazio Cusmano, Salvatore Di Lauro, Alessandro Tirrito, Francesca Di Salvo, Francesco Orlando , et al. · 2025

Introduction Heart failure is a systemic disorder often endemic in older and frail patients, associated with increased long-term mortality, reduced health-related quality of life and greater likelihood of hospital readmission. Intensive ca…

Heart failure and early cardiac rehabilitation: pilot experience and definition of the patient journey Open

Francesca Di Salvo, Ignazio Cusmano, Monica Loguercio, Salvatore Di Lauro, Paola Grati , et al. · 2025

Background Cardiac rehabilitation (CR) is a multidisciplinary intervention which has provided consistent achievements in improving cardiovascular prognosis and quality of life across different settings, including ischemic heart disease and…

Extracellular vesicles as biomarkers of the regenerative mechanisms induced by rehabilitation after heart transplantation Open

Silvia Picciolini, Aurora Mangolini, Alice Gualerzi, Paolo Pedersini, Francesca Di Salvo , et al. · 2025

Background Cardiac rehabilitation (CR) is a complex multidisciplinary intervention that may be effective in reversing the pathophysiological consequences occurring after Heart Transplantation (HT). To promote functional recovery, the patie…

OsteopaThic, logopedIc and psychological assessment To improve outcome in pAtieNts undergoIng Cardiac surgery: a randomized clinical trial (TITANIC trial) Open

Eleonora Volpato, Leone Stilo, Monica Tavanelli, Bruno Bordoni, Letizia Oreni , et al. · 2025

Background Postoperative pain and swallowing disorders are complex, multifactorial phenomenon that frequently occur after cardiac surgery. Preoperative anxiety and the interaction between sex and other sociocultural factors may predict gre…

Clinical outcomes associated with temporary mechanical circulatory support in the AltShock-2 registry: a propensity score matching analysis Open

Giovanni Tavecchia, Andrea Montisci, Gaetano Maria De Ferrari, Simone Frea, L Patrini , et al. · 2025

Background Nationwide data on temporary mechanical circulatory support (tMCS) for cardiogenic shock (CS) have shown mixed results, likely due to variations in the etiology of CS, timing of device implantation, and access to advanced therap…

Prognostic role of lung ultrasound in cardiogenic shock patients: a prospective registry based analysis Open

Costanza Natalia Julia Colombo, L Patrini, Alice Sacco, Nuccia Morici, Federico Pappalardo , et al. · 2025

Background/Introduction - Lung ultrasound (LUS) is a technique widely validated to assess lung de-aeration, identified by presence and quantification of B lines. The extent of lung field occupied by B lines is associated with the severity …

Right heart, wrong again: why do we keep ignoring tricuspid regurgitation in cardiogenic shock? Open

C. Pelosi, Alessandro Fasolino, Giovanna Viola, G Maj, C Sorini-Dini , et al. · 2025

Purpose describe the incidence and the prognostic relevance of TR in patients with CS, a setting in which few data are available. Methods We enrolled 725 consecutive patients admitted to the Altshock-2 registry (a multicenter prospective s…

Insights from the Altshock-2 registry on intra-aortic balloon pump use in acute decompensated heart failure complicated by cardiogenic shock Open

Giacomo Ruzzenenti, Chiara Colombo, G Maj, Simone Frea, C Sorini-Dini , et al. · 2025

Introduction and purpose intra-aortic balloon pump (IABP) is an ECG-gated, volume-displacement device that, while only modestly increasing cardiac output, significantly reduces left ventricle (LV) afterload. Acute decompensated heart failu…

Early Intra-Aortic Balloon Support for Heart Failure-Related Cardiogenic Shock Open

Nuccia Morici, Alice Sacco, Simone Frea, Matteo Rota, Luca Villanova , et al. · 2025

Sodium nitroprusside in heart failure-related and acute myocardial infarction-related cardiogenic shock: friend or foe? Open

Alessandro Fasolino, Rita Camporotondo, G Maj, Giovanna Viola, Simone Frea , et al. · 2025

Background Cardiogenic shock (CS) is a clinical syndrome associated with high morbidity and mortality, highly prevalent in the modern-era cardiac intensive care unit (CICU). Vasodilator therapy with intravenous sodium nitroprusside (SNP) h…

The impact of sex on outcomes and interaction with temporary mechanical circulatory support in cardiogenic shock: insights from the Altshock-2 Registry Open

Maurizio Bertaina, Carlotta Sorini Dini, Alice Sacco, Giovanna Viola, Martina Briani , et al. · 2025

Background Cardiogenic shock (CS) is the most severe form of acute heart failure and is characterized by an ominous short-term prognosis.Among potential therapeutic interventions in this setting the use of temporary mechanical circulatory …

Elevated glucose levels at 24 hours predict mortality in cardiogenic shock Open

A Cesari, Rita Camporotondo, G Maj, Simone Frea, L Villanova , et al. · 2025

Background Hyperglycemia is associated with poor outcomes in critically ill patients. However, its role as a predictor of outcomes in cardiogenic shock (CS) remains unclear due to conflicting evidence in the literature. Purpose Our study a…

Machine-learning phenotyping of patients with functional mitral regurgitation undergoing transcatheter edge-to-edge repair: the MITRA-AI study Open

Fabrizio D’Ascenzo, Filippo Angelini, Corrado Pancotti, Pier Paolo Bocchino, Cristina Giannini , et al. · 2025

Aims Severe functional mitral regurgitation (FMR) may benefit from mitral transcatheter edge-to-edge repair (TEER), but selection of patients remains to be optimized. Objectives The aim of this study was to use machine-learning (ML) approa…

ENIGMA-shock: protocol for a study framEwork for aN InteGrated assessMent of cArdiac rehabilitation programmes in patients acutely managed for cardiogenic shock Open

Nuccia Morici, Emanuela Foglia, LB Ferrario, Paolo Pedersini, Marco Corda , et al. · 2025

Introduction The treatment of patients with cardiogenic shock (CS) has been focused historically on single interventions (medical treatments, percutaneous and surgical interventions and, more recently, various temporary mechanical circulat…

Incidence and predictors of weaning failure from veno‐arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock Open

Angela Dettling, Caroline Kellner, Jonas Sundermeyer, Benedikt N. Beer, Lisa Besch , et al. · 2025

Aims This study aimed to investigate incidence and predictors of weaning failure and in‐hospital death after successful weaning from veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) in patients with cardiogenic shock (CS). Metho…

Older women with non-ST-elevation acute coronary syndrome undergoing invasive or conservative management: an individual patient data meta-analysis Open

Francesca Rubino, Graziella Pompei, Gregory Mills, Christos P. Kotanidis, Claudio Laudani , et al. · 2024

Aims Women and older patients are underrepresented in randomized controlled trials (RCTs) investigating treatment strategies following acute coronary syndrome. This study aims to evaluate the benefit of invasive vs. conservative strategy o…

Impact of biological sex on heart transplant patients admitted to cardiac rehabilitation: A 10-year retrospective cohort study Open

Andrea Tedeschi, Ignazio Cusmano, Francesca Di Salvo, Letizia Oreni, Anastasia Toccafondi , et al. · 2024

Ventilation strategies in cardiogenic shock: Insights from the <span>AltShock</span>‐2 registry Open

Alice Sacco, Andrea Montisci, Giovanni Tavecchia, Simone Frea, Davide Paolo Bernasconi , et al. · 2024

Aims To describe the use and the relation to outcome of different ventilation strategies in a contemporary, large, prospective registry of cardiogenic shock patients. Methods and results Among 657 patients enrolled from March 2020 to Novem…

Post-Myocardial Infarction Rehabilitation: The Absence in the Rehabilitation Process of the Diaphragm Muscle Open

Bruno Bordoni, Luca Mapelli, Anastasia Toccafondi, Francesca Di Salvo, Gianmarco Cannadoro , et al. · 2024

Myocardial infarction (MI) is one of the leading causes of death worldwide. There can be many reasons that cause MI, such as a sedentary lifestyle, a disordered diet, harmful habits such as smoking and alcoholism, concomitant congenital or…

Non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting: a meta-analysis of invasive vs. conservative management Open

Matthew Kelham, Rohan Vyas, Rohini Ramaseshan, Krishnaraj S. Rathod, Robbert J. de Winter , et al. · 2024

Background and Aims A routine invasive strategy is recommended in the management of higher risk patients with non-ST-elevation acute coronary syndromes (NSTE-ACSs). However, patients with previous coronary artery bypass graft (CABG) surger…

Heart Failure Management through Telehealth: Expanding Care and Connecting Hearts Open

Andrea Tedeschi, Matteo Palazzini, Giancarlo Trimarchi, Nicolina Conti, Francesco Di Spigno , et al. · 2024

Heart failure (HF) is a leading cause of morbidity worldwide, imposing a significant burden on deaths, hospitalizations, and health costs. Anticipating patients’ deterioration is a cornerstone of HF treatment: preventing congestion and end…

Respiratory support modalities in cardiogenic shock: insights from a prospective multicenter registry Open

Giovanni Tavecchia, Simone Frea, G De Ferrari, Carlotta Sorini Dini, Martina Briani , et al. · 2024

Funding Acknowledgements None. Background Respiratory support is a vital component of the comprehensive management of cardiogenic shock (CS). However, there is a lack of data comparing the application of different respiratory support modal…

Acute-on-chronic heart failure leading to cardiogenic shock: any role for intra-aortic balloon pump? Results from a multicenter retrospective data collection Open

Costanza Natalia Julia Colombo, Alice Sacco, L Villanova, Angelo Calini, V Dammassa , et al. · 2024

Funding Acknowledgements None. Background Intra-aortic balloon pump (IABP) implantation has been significantly reduced since IABP-SHOCK II trial did not show any clinical benefit in acute myocardial infarction (AMI)-related cardiogenic sho…

Acute kidney injury in acute decompensated heart failure related cardiogenic shock: data from the Alt-Shock2 registry Open

Martina Milani, Giovanni Tavecchia, Simone Frea, Carlotta Sorini Dini, Martina Briani , et al. · 2024

Funding Acknowledgements None. Background Acute kidney injury (AKI) is one of the most common complications in patients with cardiogenic shock (CS), proving the strict relationship between heart and kidney (the so-called cardio-renal syndr…

De-escalating treatments and transitioning care in a cardiac intensive care units network Open

Alice Sacco, Giovanni Tavecchia, Simone Frea, Carlotta Sorini Dini, Martina Briani , et al. · 2024

Funding Acknowledgements None. Background Recent data (1) have shown that end-of-life (EOL) management of patients with acute decompensated heart failure (ADHF) in Cardiac Intensive Care Units (CICU) is aggressive, with late or no involvem…

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