Explanipedia

Correction: Child-mother relationships and childhood dietary patterns in the Iberian Peninsula uncovered by Bayesian isotopic approaches Open

Alice Toso, Sílvia Casimiro, Charlotte Oxborough, Simona Schifano, Maite Iris García Collado , et al. · 2025

Child-mother relationships and childhood dietary patterns in the Iberian Peninsula uncovered by Bayesian isotopic approaches Open

Alice Toso, Sílvia Casimiro, Charlotte Oxborough, Simona Schifano, Maite Iris García Collado , et al. · 2025

This study examines trends in infant diet, breastfeeding and weaning in Portugal through time in Roman, Medieval Muslim and Christian skeletal assemblages (1st to the 15th century CE). New stable carbon (δ 13 C) and nitrogen (δ 15 N) measu…

Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection Open

Simon Carlile, Seán Cahill, Eóin C. O’Brien, Nuno Neto, Michael G. Monaghan , et al. · 2024

Staphylococcus aureus can induce trained immunity in murine macrophages offering protection against repeat exposure during S. aureus skin infection. Here we demonstrate that S. aureus exposure can result in non-specifi…

Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset Open

Megan M. Hanlon, Conor M. Smith, Mary Canavan, Nuno Neto, Qingxuan Song , et al. · 2024

This study performed an in-depth investigation into the myeloid cellular landscape in the synovium of patients with rheumatoid arthritis (RA), “individuals at risk” of RA, and healthy controls (HC). Flow cytometric analysis demonstrated th…

2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified Open

Nuno Neto, Meenakshi Suku, David A. Hoey, Michael G. Monaghan · 2023

Background Human mesenchymal stem cells (hMSCs) utilize discrete biosynthetic pathways to self-renew and differentiate into specific cell lineages, with undifferentiated hMSCs harbouring reliance on glycolysis and hMSCs differentiating tow…

Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure Open

Farhad Chariyev‐Prinz, Nuno Neto, Michael G. Monaghan, Daniel J. Kelly · 2023

It is generally accepted that the application of hydrostatic pressure (HP) is beneficial for MSC chondrogenesis. There is, however, evidence to suggest that the timing of application might determine its impact on cell fate and tissue devel…

An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis Open

Farhad Chariyev‐Prinz, Alex Szojka, Nuno Neto, Ross Burdis, Michael G. Monaghan , et al. · 2023

Mechanical stimulation can modulate the chondrogenic differentiation of stem/progenitor cells and potentially benefit tissue engineering (TE) of functional articular cartilage (AC). Mechanical cues like hydrostatic pressure (HP) are often …

2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified Open

Nuno Neto, Meenakshi Suku, David A. Hoey, Michael G. Monaghan · 2023

I. Background : Human mesenchymal stem cells (hMSCs) fuel discrete biosynthetic pathways to multiply and differentiate into specific cell lineages; with undifferentiated hMSCs showing reliance on glycolytic respiration. hMSCs differentiati…

Macrophage metabolic profile is altered by hydroxyapatite particle size Open

Lianne C. Shanley, Olwyn R. Mahon, Sinead A O’Rourke, Nuno Neto, Michael G. Monaghan , et al. · 2023

Since the recent observation that immune cells undergo metabolic reprogramming upon activation, there has been immense research in this area to not only understand the basis of such changes, but also to exploit metabolic rewiring for thera…

2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified Open

Nuno Neto, Meenakshi Suku, David A. Hoey, Michael G. Monaghan · 2023

Human mesenchymal stem cells (hMSCs) fuel discrete biosynthetic pathways to multiply and differentiate into specific cell lineages; with undifferentiated hMSCs showing reliance on glycolysis. hMSCs differentiating towards an osteogenic phe…

Computational approaches in rheumatic diseases – Deciphering complex spatio-temporal cell interactions Open

C. Hegarty, Nuno Neto, Paul A. Cahill, Achilleas Floudas · 2023

Inflammatory arthritis, including rheumatoid (RA), and psoriatic (PsA) arthritis, are clinically and immunologically heterogeneous diseases with no identified cure. Chronic inflammation of the synovial tissue ushers loss of function of the…

Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis Open

Mary F. Rooney, Nuno Neto, Michael G. Monaghan, Emmeline W. Hill, Richard K. Porter · 2022

Los judíos en Olisipo (Lisboa). Reflexiones a partir de un posible sello de panadero Open

Ricardo Ávila Ribeiro, Nuno Neto, Paulo Rebelo, Macarena Bustamante álvarez · 2022

Se presenta un sello circular cerámico con iconografía hebraica localizado en Lisboa en un contexto de época tardorromana. En él aparece una menorah esquematizada. En el presente trabajo, además de realizar un análisis iconográfico, tipoló…

A preclinical model of cutaneous melanoma based on reconstructed human epidermis Open

Anna Leikeim, Maximiliane Wußmann, Freia F. Schmidt, Nuno Neto, Franziska Benz , et al. · 2022

Malignant melanoma is among the tumor entities with the highest increase of incidence worldwide. To elucidate melanoma progression and develop new effective therapies, rodent models are commonly used. While these do not adequately reflect …

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning Open

Nuno Neto, Sinead A O’Rourke, Mimi Zhang, Hannah K. Fitzgerald, Aisling Dunne , et al. · 2022

In this study, we utilise fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence as a non-invasive modality to classify two contrasting states of human macrophages by proxy of their governing metabolic state. Macrophages …

Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis. Open

Emmeline W. Hill, Richard K. Porter, Nuno Neto, Michael G. Monaghan, Mary F. Rooney · 2022

BackgroundThoroughbred racehorse performance is largely influenced by a major quantitative trait locus at the myostatin ( MSTN ) gene which determines aptitude for certain race distances due to a promoter region insertion mutation influenc…

Geoarchaeology of the alluvial plain deposits at Entrecampos, Lisboa: first insights for a stratigraphic reconstruction  Open

Luís Almeida, Maurizio Zambaldi, Cristina Gameiro, João Leónidas, Nelson Antunes , et al. · 2022

<p>In the framework of a preventive archaeological excavation at the <em>Unidade de Execução de Entrecampos - Parcela A</em> (UEE-PA) in central Lisbon, Portugal, a sedimentary successi…

OP0013 LOSS OF SYNOVIAL TISSUE MACROPHAGE HOMEOSTASIS PRECEDES RHEUMATOID ARTHRITIS CLINICAL ONSET Open

M. Hanlon, Mary Canavan, Nuno Neto, Qingxuan Song, P. Gallagher , et al. · 2022

Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages Open

Sinead A O’Rourke, Nuno Neto, Eimear Devilly, Lianne C. Shanley, Hannah K. Fitzgerald , et al. · 2022

This study not only provides further insight into how atherosclerosis-associated DAMPs impact on immune cell function, but also highlights metabolic reprogramming as a potential therapeutic target for cholesterol crystal-related inflammati…

Author response: Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning Open

Nuno Neto, Sinead A O’Rourke, Mimi Zhang, Hannah K. Fitzgerald, Aisling Dunne , et al. · 2022

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Abstract In this study, we utilise fluo…

Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis Open

Achilleas Floudas, Áine Gorman, Nuno Neto, Michael G. Monaghan, Zoe Elliott , et al. · 2022

Inflammatory arthritis is a chronic systemic autoimmune disease of unknown etiology, which affects the joints. If untreated, these diseases can have a detrimental effect on the patient's quality of life, leading to disabilities, and theref…

Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning Open

Nuno Neto, Sinead A O’Rourke, Mimi Zhang, Hannah K. Fitzgerald, Aisling Dunne , et al. · 2022

1. Abstract In this study, fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence is applied as a non-invasive modality to classify two contrasting states of human macrophages by proxy of their governing metabolic state. …

The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells Open

Hannah K. Fitzgerald, Sinead A O’Rourke, Eva Desmond, Nuno Neto, Michael G. Monaghan , et al. · 2022

The extracellular parasite and causative agent of African sleeping sickness Trypanosoma brucei (T. brucei) has evolved a number of strategies to avoid immune detection in the host. One recently described mechanism involves the conversion o…

A Preclinical Model of Cutaneous Melanoma Based on Reconstructed Human Epidermis Open

Florian Groeber‐Becker, Anna Leikeim, Maximiliane Wußmann, Freia F. Schmidt, Nuno Neto , et al. · 2022

Malignant melanoma is among the tumor entities with the highest increase of incidence worldwide. To elucidate melanoma progression and develop new effective therapies, rodent models are commonly used. While these do not adequately reflect …

Development of an Inclusive Multiplayer Serious Game for Deaf and Blind Open

Nuno Neto, Bruno Galasso, Dirceu Teixeira, Paula Escudeiro · 2022

The paper presents the development of an inclusive serious multiplayer game with Morse code as its theme, as well as describing methodologies and architectures for developing a serious game through specific concepts for the deaf (sign lang…

Macrophage Metabolic Profile is Altered by Hydroxyapatite Particle Size Open

Lianne C. Shanley, Olwyn R. Mahon, Sinead A O’Rourke, Nuno Neto, Michael G. Monaghan , et al. · 2022

Inclusive Digital Learning through Serious Games: a Clipping for Inclusion Open

Paula Escudeiro, Dirceu Teixeira, Bruno Galasso, Nuno Neto, Flávio Costa · 2022

Serious games have a great potential to help the population develop new skills or improve previously existing ones. However, part of the population does not have the means to play these games. Therefore, this article aims to discuss the us…

Conditionally Immortalised Equine Skeletal Muscle Cell Lines for in Vitro Analysis Open

Mary F. Rooney, Nuno Neto, Michael G. Monaghan, Emmeline W. Hill, Richard K. Porter · 2021

Background Thoroughbred racehorse performance is largely influenced by a major quantitative trait locus at the myostatin ( MSTN ) gene which determines aptitude for certain race distances due to a promoter region insertion mutation influen…

Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip Open

Simone Perottoni, Nuno Neto, Cesare Di Nitto, Ruslan I. Dmitriev, Manuela Teresa Raimondi , et al. · 2021

The stem cell niche at the perivascular space plays a role in dictating the fate of stem cells within it. This study predicts in silico and models the perivascular space, in a miniaturised bioreactor, with non-invasive assessment of cell m…

Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint Open

Achilleas Floudas, Nuno Neto, Viviana Marzaioli, Kieran Murray, Barry Moran , et al. · 2020

While autoantibodies are used in the diagnosis of rheumatoid arthritis (RA), the function of B cells in the inflamed joint remains elusive. Extensive flow cytometric characterization and SPICE algorithm analyses of single-cell synovial tis…

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