Explanipedia

Sex-related cardiometabolic differences in ME/CFS patients Open

Lidija Hofmann, Danka Jeremić, Luis León, Cornelia Pipper-Krampl, Daniel Pfurtscheller , et al. · 2025

Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome Open

Friederike Hoheisel, Kathrin Fleischer, Kerstin Rubarth, Nuno Sepúlveda, Sandra Bauer , et al. · 2025

Introduction Epstein-Barr virus (EBV) infection is a well-established trigger and risk factor for both myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we identified elevated I…

Statistical Triage Model for Feline Infectious Diseases in a Veterinary Isolation Unit: The Case of Feline Immunodeficiency and Leukemia Viruses Open

Miguel M. Maximino, I. Machado, Telmo Nunes, Luís Tavares, Virgílio Almeida , et al. · 2025

Isolation units in veterinary hospitals are essential for managing infectious diseases, but limited resources in staff, equipment and budget make timely triage difficult. In this scenario, data-driven models, if trained with high-quality d…

Autoantibodies to Arginine-rich Sequences Mimicking Epstein-Barr Virus in Post-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Open

Friederike Hoheisel, Kathrin Fleischer, Kerstin Rubarth, Nuno Sepúlveda, Sandra Bauer , et al. · 2024

Background Epstein-Barr virus (EBV) infection is a known trigger and risk factor for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we found enhanced IgG reactivity to EBV EB…

On the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after a SARS-CoV-2 infection Open

Nuno Sepúlveda, Francisco Westermeier · 2024

Editorial: On the cusp of the silent wave of the long COVID pandemic: why, what and how should we tackle this emerging syndrome in the clinic and population? Open

Francisco Westermeier, Nuno Sepúlveda · 2024

Post-Infection Fatigue Syndromes in the Era of Long COVID: The Case of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Open

Nuno Sepúlveda, João Malato, João Carlos Winck, António Vaz Carneiro, Joan Serra Hoffman , et al. · 2024

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Sex and disease severity-based analysis of steroid hormones in ME/CFS Open

Cornelia Pipper, Linda Bliem, Luis León, Daniela Mennickent, Claudia Bodner , et al. · 2024

Developing a Feline Infectious Disease Triage Model: Insights from Logistic Regression Models in Data from a Veterinary Isolation Unit Open

Miguel M. Maximino, I. Machado, Telmo Nunes, Luís Tavares, Virgílio Almeida , et al. · 2024

Background: The Biological Isolation and Containment Unit (BICU) of the Faculty of Veterinary Medicine, University of Lisbon, is dedicated to treating animals with suspected or confirmed infectious diseases. Feline Immunodeficiency Virus (…

Antibody selection strategies and their impact in predicting clinical malaria based on multi-sera data Open

André Fonseca, Mikolaj Spytek, Przemysław Biecek, Clara Cordeiro, Nuno Sepúlveda · 2024

IgG Antibody Responses to Epstein-Barr Virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Their Effective Potential for Disease Diagnosis and Pathological Antigenic Mimicry Open

André Fonseca, Mateusz Szysz, Hoang Thien Ly, Clara Cordeiro, Nuno Sepúlveda · 2024

Background and Objectives: The diagnosis and pathology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain under debate. However, there is a growing body of evidence for an autoimmune component in ME/CFS caused by the Eps…

Classification Methods for the Serological Status Based on Mixtures of Skew-Normal and Skew-t Distributions Open

Tiago Dias Domingues, Helena Mouriño, Nuno Sepúlveda · 2024

Gaussian mixture models are widely employed in serological data analysis to discern between seropositive and seronegative individuals. However, serological populations often exhibit significant skewness, making symmetric distributions like…

IgG Antibody Responses to Epstein-Barr Virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Their Effective Potential for Disease Diagnosis and Pathological Antigenic Mimicry Open

André Fonseca, Mateusz Szysz, Hoang Thien Ly, Clara Cordeiro, Nuno Sepúlveda · 2023

The diagnosis and the pathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) remain under debate. However, there is a growing body of evidence for an autoimmune component in ME/CFS caused by the Epstein-Barr virus (EBV) a…

The importance of estimating prevalence of ME/CFS in future epidemiological studies of long COVID Open

Anna D. Grabowska, Francisco Westermeier, Luís Nacul, Eliana Lacerda, Nuno Sepúlveda · 2023

OPINION article Front. Public Health, 03 November 2023Sec. Infectious Diseases: Epidemiology and Prevention Volume 11 - 2023 | https://doi.org/10.3389/fpubh.2023.1275827

Sex and disease severity-based analysis of steroid hormones in ME/CFS Open

Cornelia Pipper, Linda Bliem, Luis León, Daniela Mennickent, Claudia Bodner , et al. · 2023

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by decreased daily activity and persistent fatigue after physical and/or cognitive exertion. Although ME/CFS affects both sexes, there is a…

Editorial: Reproducibility and rigour in infectious diseases - surveillance, prevention and treatment Open

Francisco Westermeier, Nuno Sepúlveda · 2023

EDITORIAL article Front. Med., 11 October 2023Sec. Infectious Diseases: Pathogenesis and Therapy Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1294969

Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center Open

Sophie Steiner, Annick Fehrer, Friederike Hoheisel, Simon Schoening, Anna C. Aschenbrenner , et al. · 2023

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevale…

Interplay between Systemic Glycemia and Neuroprotective Activity of Resveratrol in Modulating Astrocyte SIRT1 Response to Neuroinflammation Open

Anna D. Grabowska, Mateusz Wątroba, Joanna Witkowska, Agnieszka Mikulska, Nuno Sepúlveda , et al. · 2023

The flow of substances between the blood and the central nervous system is precisely regulated by the blood–brain barrier (BBB). Its disruption due to unbalanced blood glucose levels (hyper- and hypoglycemia) occurring in metabolic disorde…

Association analysis between symptomology and herpesvirus IgG antibody concentrations in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis Open

Tiago Dias Domingues, João Malato, Anna D. Grabowska, Ji‐Sook Lee, Jose Ameijeiras‐Alonso , et al. · 2023

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS) are two complex and multifactorial diseases whose patients experience persistent fatigue, cognitive impairment, among other shared symptoms. The onset …

Epidemiologic Factors Supporting Triage of Infected Dog Patients Admitted to a Veterinary Hospital Biological Isolation and Containment Unit Open

I. Machado, Telmo Nunes, Miguel M. Maximino, João Malato, Luís Tavares , et al. · 2023

The teaching hospital of the Faculty of Veterinary Medicine at the University of Lisbon hosts a Biological Isolation and Containment Unit (BICU) for the hospitalization of both confirmed and suspected animals of an infectious disease. This…

Editorial: Current research on serological analyses of infectious diseases Open

Eric Rogier, Emanuele Giorgi, Kevin K. A. Tetteh, Nuno Sepúlveda · 2023

EDITORIAL article Front. Med., 17 February 2023Sec. Infectious Diseases: Pathogenesis and Therapy Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1154584

Impact of Misdiagnosis in Case-Control Studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Open

João Malato, Luís Graça, Nuno Sepúlveda · 2023

Misdiagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can occur when different case definitions are used by clinicians (relative misdiagnosis) or when failing the genuine diagnosis of another disease (misdiagnosis in …

Antibody selection strategies and their impact in the analysis of malaria multi-sera data Open

André Fonseca, Mikolaj Spytek, Przemysław Biecek, Clara Cordeiro, Nuno Sepúlveda · 2022

Background Nowadays, the chance of discovering the best antibody candidates for explaining naturally acquired protection to malaria and detecting exposure to malaria parasites has notably increased due to publicly available multi-sera data…

Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity Open

Franziska Sotzny, Igor Salerno Filgueiras, Claudia Kedor, Helma Freitag, Kirsten Wittke , et al. · 2022

Most patients with Post COVID Syndrome (PCS) present with a plethora of symptoms without clear evidence of organ dysfunction. A subset of them fulfills diagnostic criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Sym…

Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde Open

Daniel Ward, Ana Gomes, Kevin K. A. Tetteh, Nuno Sepúlveda, Lara Ferrero Gómez , et al. · 2022

Revisiting IgG Antibody Reactivity to Epstein-Barr Virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Its Potential Application to Disease Diagnosis Open

Nuno Sepúlveda, João Malato, Franziska Sotzny, Anna D. Grabowska, André Fonseca , et al. · 2022

Infections by the Epstein-Barr virus (EBV) are often at the disease onset of patients suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). However, serological analyses of these infections remain inconclusive when co…

Impact of imperfect diagnosis in ME/CFS association studies Open

João Malato, Luís Graça, Nuno Sepúlveda · 2022

The absence of an objective disease biomarker puts studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) under the curse of imperfect diagnosis. This problem leads to frequent reports that fail to reproduce prior published…

Revisiting IgG antibody reactivity to Epstein-Barr virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and its potential application to disease diagnosis Open

Nuno Sepúlveda, João Malato, Franziska Sotzny, Anna D. Grabowska, André Fonseca , et al. · 2022

Infections by the Epstein-Barr virus (EBV) are often at the disease onset of patients suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). However, serological analyses of these infections remain inconclusive when co…

Editorial: Current Insights Into Complex Post-infection Fatigue Syndromes With Unknown Aetiology: The Case of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Beyond Open

Francisco Westermeier, Eliana Lacerda, Carmen Scheibenbogen, Nuno Sepúlveda · 2022

EDITORIAL article Front. Med., 24 February 2022 | https://doi.org/10.3389/fmed.2022.862953

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients Open

Romina Bertinat, Roberto Villalobos-Labra, Lidija Hofmann, J. Blauensteiner, Nuno Sepúlveda , et al. · 2022

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by severe and persistent fatigue. Along with clinical studies showing endothelial dysfunction (ED) in a subset of ME/CFS patients, we have …

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