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View article: Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in Ameliorating Renal Fibrosis: A Comprehensive Narrative Review
Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in Ameliorating Renal Fibrosis: A Comprehensive Narrative Review Open
Chronic kidney disease (CKD) represents a global health challenge with limited therapeutic options, often progressing to end-stage renal disease requiring dialysis or transplantation. Renal fibrosis, characterized by excessive extracellula…
View article: Hyptolide Promotes Breast Cancer Stem Cells Apoptosis and S-phase Cell Cycle Arrest
Hyptolide Promotes Breast Cancer Stem Cells Apoptosis and S-phase Cell Cycle Arrest Open
Taken together, hyptolide has potential for treating BCSCs by targeting SRC, EGFR, and MAPK1 signaling. Further investigation of the molecular mechanisms involved is required to develop hyptolide as a BCSC-targeted drug.
View article: Mesenchymal stem cell-derived secretome accelerates third-degree burn wound healing: Effects on proliferation, angiogenesis, and fibrosis regulation
Mesenchymal stem cell-derived secretome accelerates third-degree burn wound healing: Effects on proliferation, angiogenesis, and fibrosis regulation Open
Mesenchymal stem cell-derived secretome (MSC-derived secretome) has shown promise in regenerative medicine; however, research specifically evaluating its efficacy in third-degree burn wounds remains scarce. The aim of this study was to inv…
View article: High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes
High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes Open
Breast cancer (BC) is a global health concern with significant mortality rates, necessitating a deep understanding of its molecular landscape. Luminal A and B BC, characterized by estrogen receptor (ER) and/or progesterone receptor (PR) po…
View article: Hypoxia-conditioned mesenchymal stem cells (MSC) exosomes attenuate ultraviolet-B (UVB)-mediated malondialdehyde (MDA) and matrix metalloproteinase-1 (MMP)-1 upregulation in collagen loss models
Hypoxia-conditioned mesenchymal stem cells (MSC) exosomes attenuate ultraviolet-B (UVB)-mediated malondialdehyde (MDA) and matrix metalloproteinase-1 (MMP)-1 upregulation in collagen loss models Open
<p><strong>Aim</strong> To investigate the effects of exosome-derived human mesenchymal stem cells (EH-MSCs) on matrix metalloproteinase-1 (MMP)-1 and malondialdehyde (MDA) levels in ultraviolet-B (UVB)-irradiated Wistar …
View article: Improved wound healing in superficial wound infection through a-SMA upregulation and increased collagen density by the secretome of hypoxic mesenchymal stem cells
Improved wound healing in superficial wound infection through a-SMA upregulation and increased collagen density by the secretome of hypoxic mesenchymal stem cells Open
Background/Aim: Superficial wound infections cause delayed remodeling by suppressing the expression of Alpha-smooth muscle actin (a-SMA), which inhibits collagen synthesis. Secretomes derived from hypoxic mesenchymal stem cells (SH-MSCs) c…
View article: Hypoxic mesenchymal stem cell secretome upregulates IL-10 and STAT3 gene expressions in mice model with polycystic ovary syndrome
Hypoxic mesenchymal stem cell secretome upregulates IL-10 and STAT3 gene expressions in mice model with polycystic ovary syndrome Open
Polycystic Ovary Syndrome (PCOS) is a condition characterized by chronic anovulation and hyperandrogenism, which often leads to infertility. It is closely associated with chronic inflammation triggered by glucose and saturated fat, contrib…
View article: The Effect of Celery Extract on Caspase-3 and TNF-α Gene Expression in Lead Poisoning-Induced Renal Injury in Rats
The Effect of Celery Extract on Caspase-3 and TNF-α Gene Expression in Lead Poisoning-Induced Renal Injury in Rats Open
Background To determine the effect of Apium graveolens L (Celery) extract in the TNF-α and caspase-3 gene expression on the lead poisoning-induced renal injury rats’ model. Methods This study is experimental research with post test only co…
View article: Anti-inflammation effect of Apium graveolens Extract against lead-acetate-induced brain injury in rats
Anti-inflammation effect of Apium graveolens Extract against lead-acetate-induced brain injury in rats Open
Purpose: The current study investigated the protective potential of Apium graveolens extract (APE) against lead-induced brain injury in rats by exploring anti-inflammatory and antiapoptotic mechanism. Methods: Twenty male Wistar rats were …
View article: Inhibitory Effects of Petai Peel Extract Gel on Tyrosinase and TRP1 Gene Expression in UVB-Exposed Mouse Skin
Inhibitory Effects of Petai Peel Extract Gel on Tyrosinase and TRP1 Gene Expression in UVB-Exposed Mouse Skin Open
Background: UVB irradiation can induce the formation of Reactive Oxygen Species (ROS), which causes the activation of melanin synthesis through the activation of tyrosinase and tyrosinase-related protein-1 (TRP1). Secondary metabolites in …
View article: Hypoxia Mesenchymal Stem Cell Secretome Enhances IL-10 via STAT3 Pathway in a Rat PCOS Model
Hypoxia Mesenchymal Stem Cell Secretome Enhances IL-10 via STAT3 Pathway in a Rat PCOS Model Open
Background Polycystic ovary syndrome(PCOS) is a condition of chronic anovulation and hyperandrogenism which commonly causes infertility. PCOS is closely associated with chronic inflammation triggered by glucose and saturated fat, causing h…
View article: Unveiling the Potential of Hyptis Capitata and Hyptis Brevipes Compounds in Overcoming Apoptosis Resistance and Inducing Targeted Cell Cycle Arrest in Breast Cancer Stem Cells
Unveiling the Potential of Hyptis Capitata and Hyptis Brevipes Compounds in Overcoming Apoptosis Resistance and Inducing Targeted Cell Cycle Arrest in Breast Cancer Stem Cells Open
Breast cancer stem cells (CSC), as a kind of tumor cells, are able to regenerate themselves, leading to apoptosis resistance and cancer relapse. In this study, we investigated the potential of Hyptis Capitata and Hyptis Brevipes compounds …
View article: Enhanced Third Degree Burn Wound Healing by Hypoxic Mesenchymal Stem Cells' Secretome: IL-10 Upregulation and TNF-α/PGE2 Suppression
Enhanced Third Degree Burn Wound Healing by Hypoxic Mesenchymal Stem Cells' Secretome: IL-10 Upregulation and TNF-α/PGE2 Suppression Open
Background: Severe third-degree burns pose a notable obstacle in clinical settings, frequently leading to hindered healing of wounds and the development of scars. In this research, we explored how the secretome of hypoxic mesenchymal stem …
View article: Pengendalian Manajemen Sebagai Upaya Mengoptimalkan Kinerja Keuangan
Pengendalian Manajemen Sebagai Upaya Mengoptimalkan Kinerja Keuangan Open
Background – The debt phenomenon is very crucial in the company. Many entrepreneurs go bankrupt or fail to pay due to debts owned by the company so that debt has a big pressure on generating company profits. Aim – This research is to analy…
View article: Enhanced Wound Healing in Superficial Infection Wounds Through α-SMA Upregulation and Collagen Density Increase by Secretome Hypoxia Mesenchymal Stem Cells
Enhanced Wound Healing in Superficial Infection Wounds Through α-SMA Upregulation and Collagen Density Increase by Secretome Hypoxia Mesenchymal Stem Cells Open
Background: Superficial wound infections lead to delayed remodeling due to the suppression of alpha-smooth muscle actin (α-SMA) gene expression, thus inhibiting collagen synthesis. Secretomes from hypoxia mesenchymal stem cells (SH-MSCs) c…
View article: Clitoria ternatea Flower Extract Inhibits Matrix Mettaloproteinase-3 leading to the promotion of α-SMA Gene Expression in UVB-Induced Rat Model
Clitoria ternatea Flower Extract Inhibits Matrix Mettaloproteinase-3 leading to the promotion of α-SMA Gene Expression in UVB-Induced Rat Model Open
This study aimed to determine the effect of administration of Clitorea ternatea flower extract (C. ternatea) in a gel on the expression of MMP-3 and α-SMA in the skin of rat models induced by UVB light exposure. This research design is exp…
View article: Corporate Governance Dan Kinerja Keuangan: Perusahaan Manufaktur Sektor Industri Barang Konsumsi Yang Terdaftar Di Bursa Efek Indonesia
Corporate Governance Dan Kinerja Keuangan: Perusahaan Manufaktur Sektor Industri Barang Konsumsi Yang Terdaftar Di Bursa Efek Indonesia Open
Penelitian ini bertujuan untuk mengukur dampak Tata Kelola Perusahaan terhadap kinerja Keuangan pada Perusahaan Manufaktur Sektor Industri Barang Konsumsi Yang Terdaftar di Bursa Efek Indonesia. Metodologi penelitian yang digunakan adalah …
View article: Therapeutic Potential of Secretome Hypoxia Mesenchymal Stem Cells: Downregulation of TNF-α and HIF-2α in Metabolic Syndrome-Induced Inflammation in Wistar Rats
Therapeutic Potential of Secretome Hypoxia Mesenchymal Stem Cells: Downregulation of TNF-α and HIF-2α in Metabolic Syndrome-Induced Inflammation in Wistar Rats Open
Background: Metabolic syndrome (MetS) has become a global health challenge with several associated issues, such as obesity, insulin resistance, dyslipidemia, and hypertension. Important proteins such as Tumor Necrosis Factor-alpha (TNF-α) …
View article: Pemahaman Literasi Keuangan Digital Dalam Mencegah Pinjaman Online Ilegal Pada Pengurus Ranting ‘Aisyiyah Ngasem
Pemahaman Literasi Keuangan Digital Dalam Mencegah Pinjaman Online Ilegal Pada Pengurus Ranting ‘Aisyiyah Ngasem Open
Financial Technology is financial technology developed for purposes in the financial sector. One type of Financial Technology is Peer-to-Peer (P2P) Lending, which is an information technology-based lending service. Technological innovation…
View article: Unveiling the genetic landscape: high frequency of pik3ca mutation in luminal a and b breast cancer within the Indonesian population
Unveiling the genetic landscape: high frequency of pik3ca mutation in luminal a and b breast cancer within the Indonesian population Open
Background: Breast cancer (BC) is a global health concern with significant mortality rates, necessitating a deep understanding of its molecular landscape. Objective: This study focuses on the prevalence of phosphatidylinositol-4,5-bisphosp…
View article: Secretome of Hypoxia-Preconditioned Mesenchymal Stem Cells Ameliorates Hyperglycemia in Type 2 Diabetes Mellitus Rats
Secretome of Hypoxia-Preconditioned Mesenchymal Stem Cells Ameliorates Hyperglycemia in Type 2 Diabetes Mellitus Rats Open
Introduction: Type 2 diabetes mellitus (T2DM) is a prevalent form of diabetes that affects 90 - 95 % of all diabetic patients. Insulin sensitizers and insulin exogenous supply could temporarily ameliorate hyperglycaemia; however, they are …
View article: Curcuma longa extract inhibits migration by reducing MMP-9 and Rac-1 expression in highly metastatic breast cancer cells
Curcuma longa extract inhibits migration by reducing MMP-9 and Rac-1 expression in highly metastatic breast cancer cells Open
Background and purpose: Highly metastatic breast cancer is a population of cancer cells that has metastasized to other organs in the body leading to apoptosis resistance. It was reported that MDAMB-231 cells contain lower levels of reactiv…
View article: Hypoxic mesenchymal stem cells (MSCS)-induced interleukin (IL)-10 alleviate systemic lupus erythematosus (SLE) infl ammation through inhibiting interferon (IFN)-gamma production
Hypoxic mesenchymal stem cells (MSCS)-induced interleukin (IL)-10 alleviate systemic lupus erythematosus (SLE) infl ammation through inhibiting interferon (IFN)-gamma production Open
<p><strong>Aim</strong> <br />To determine the eff ect of hypoxic mesenchymal stem cells (MSCs) on the interleukin (IL)-10 and interferon (IFN)-gamma in peripheral blood mononuclear cells (PBMCs) from systemic lupus…
View article: Analisis Dampak Manager Overconfidance dengan Mekanisme Corporate Governance Terhadap Kinerja pada Perusahaan Manufaktur
Analisis Dampak Manager Overconfidance dengan Mekanisme Corporate Governance Terhadap Kinerja pada Perusahaan Manufaktur Open
Tata kelola perusahaan telah mendapat perhatian sebagai mekanisme penting. Pesatnya pertumbuhan privatisasi, krisis keuangan global baru-baru ini, dan perkembangan lembaga keuangan telah memperkuat perbaikan praktik tata kelola perusahaan.…
View article: Caesalpinia sappan reduces the stemness of breast cancer stem cells involving the elevation of intracellular reactive oxygen species
Caesalpinia sappan reduces the stemness of breast cancer stem cells involving the elevation of intracellular reactive oxygen species Open
Background and purpose: Breast cancer stem cells (BCSCs) as a kind of tumor cells are able to regenerate themselves, leading to apoptosis resistance and cancer relapse. It was reported that BCSCs contain lower levels of reactive oxygen spe…
View article: Analisis Rasio Likuiditas Terhadap Nilai Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia
Analisis Rasio Likuiditas Terhadap Nilai Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Open
Penelitian ini bertujuan untuk mengetahui pengaruh current rasio, quick rasio dan cash rasio terhadap nilai perusahaan. Data yang digunakan dalam penelitian ini adalah data sekunder dari laporan keuangan perusahaan manufaktur yang terdafta…
View article: PELATIHAN KEUANGAN BERBASIS TEKNOLOGI UMKM SEBAGAI PENDUKUNG INTERNAL ORGANISASI
PELATIHAN KEUANGAN BERBASIS TEKNOLOGI UMKM SEBAGAI PENDUKUNG INTERNAL ORGANISASI Open
Manajemen pengelolaan Keuangan baik untuk pencatatan pemasukan dan pengeluaran sangat penting untuk perkembangan UMKM untuk dasar evaluasi sistem bisnis yang sudah berjalan dengan perkembangan teknologi yang semakin baik maka perlu adanya …
View article: Peningkatan Kapasitas Ekonomi Warga Kelurahan Patemon melalui Inovasi Abon Lele
Peningkatan Kapasitas Ekonomi Warga Kelurahan Patemon melalui Inovasi Abon Lele Open
Di masa pandemi Covid, masyarakat dihadapkan dengan permasalahan ekonomi, seperti pemutusan hubungan kerja (PHK), menurunnya pendapatan bagi sebagian para pedagang, bahkan ada yang sampai harus menutup usahanya karena terdampak pandemi. Ma…
View article: Combination Curcuma longa and Phyllanthus niruri Extract Potentiate Antiproliferative in Triple Negative Breast Cancer MDAMB-231 Cells
Combination Curcuma longa and Phyllanthus niruri Extract Potentiate Antiproliferative in Triple Negative Breast Cancer MDAMB-231 Cells Open
The combination of CL and PN exerted promising antiproliferative effects in TNBC. Therefore, CL and PN may be considered a potential source for the development of potent anticancer drugs for breast cancer treatment.
View article: Ukuran perusahaan dan leverage terhadap nilai perusahaan di Bursa Efek Indonesia: Return on equity sebagai variabel moderasi
Ukuran perusahaan dan leverage terhadap nilai perusahaan di Bursa Efek Indonesia: Return on equity sebagai variabel moderasi Open
This study examines the effect of firm size and leverage on firm value, with return on equity as a moderating variable. The data used in this study is secondary data from the financial reports of companies listed on the Indonesian Stock Ex…