Explanipedia

The Bordetella type III secretion system effector BteA targets host eosinophil-epithelial signaling to promote IL-1Ra expression and persistence Open

Katelyn M. Parrish, Nicholas J. First, Jana Kamanová, Tyler L. Williams, Sarah J. Johnson , et al. · 2025

Differential effects of proton pump inhibitors on the aryl hydrocarbon receptor in esophageal epithelial cells Open

Morgan Klein, Alexander T. Dwyer, Sierra Beach, Tomislav Ticak, Marc E. Rothenberg , et al. · 2024

Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis Open

Steven P. Proper, Alexander T. Dwyer, Andrews Appiagyei, Jennifer M. Felton, Netali Ben-Baruch Morgenstern , et al. · 2024

Introduction Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD; howe…

Aryl hydrocarbon receptor (AHR) and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis Open

Steven P. Proper, Alexander T. Dwyer, Andrews Appiagyei, Jennifer M. Felton, Netali Ben-Baruch Morgenstern , et al. · 2023

Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD, however, the mech…

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7 Open

Nurit P. Azouz, Andrea M. Klingler, Mark Rochman, Misu Paul, Julie M. Caldwell , et al. · 2023

Eosinophilic esophagitis (EoE) is a type 2 allergic disease characterized by esophageal inflammation and epithelial cell dysfunction. Acquired loss of the anti-serine protease of kazal type 7 (SPINK7) in the squamous epithelium of the esop…

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells Open

Matthew Mahoney, Vishnu C. Damalanka, Michael A. Tartell, Dong hee Chung, André Luiz Lourenço , et al. · 2021

Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help …

Achieving Precision Medicine in Allergic Disease: Progress and Challenges Open

Steven P. Proper, Nurit P. Azouz, Tesfaye B. Mersha · 2021

Allergic diseases (atopic dermatitis, food allergy, eosinophilic esophagitis, asthma and allergic rhinitis), perhaps more than many other traditionally grouped disorders, share several overlapping inflammatory pathways and risk factors, th…

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells Open

Matthew Mahoney, Vishnu C. Damalanka, Michael A. Tartell, Dong hee Chung, André Luiz Lourenço , et al. · 2021

The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and of other coronaviruses and…

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2 Open

Nurit P. Azouz, Andrea M. Klingler, Victoria Callahan, Ivan Akhrymuk, Katarina Elez , et al. · 2021

Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane s…

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat Open

Tim Hempel, Lluı́s Raich, Simon Olsson, Nurit P. Azouz, Andrea M. Klingler , et al. · 2020

The authors unravel the molecular action principle of nafamostat and camostat, two potential COVID-19 drugs targeting the human protein TMPRSS2.

Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors Open

Mark Rochman, Yong Xie, Lydia E. Mack, Julie M. Caldwell, Andrea M. Klingler , et al. · 2020

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate Open

Tim Hempel, Lluı́s Raich, Simon Olsson, Nurit P. Azouz, Andrea M. Klingler , et al. · 2020

The entry of the coronavirus SARS-CoV-2 into human cells can be inhibited by the approved drugs camostat and nafamostat. Here we elucidate the molecular mechanism of these drugs by combining experiments and simulations. In vitro assays con…

Uncovering the secretes of allergic inflammation Open

Michael Brusilovsky, Mark Rochman, Nurit P. Azouz, Lydia E. Mack, Marc E. Rothenberg · 2020

Allergic asthma is a chronic inflammatory lung disease associated with increased cytokine secretion. Aspects of airway inflammation are also linked to a common genetic variant that corresponds to the small GTPase, Rab27, a protein involved…

Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis Open

Nurit P. Azouz, Andrea M. Klingler, Purnima Pathre, John A. Besse, Netali Ben-Baruch Morgenstern , et al. · 2020

Eosinophilic esophagitis is mediated by uncontrolled proteolytic activity of kallikrein 5 influencing the epithelial barrier and innate immunity.

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2 Open

Nurit P. Azouz, Andrea M. Klingler, Victoria Callahan, Ivan Akhrymuk, Katarina Elez , et al. · 2020

Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protea…

A key role for IL-13 signaling via the type 2 IL-4 receptor in atopic dermatitis Open

Ariel Munitz, Almog Bitton, Shmuel Avlas, Hadar Reichman, Michal Itan , et al. · 2020

Mechanisms of gastrointestinal allergic disorders Open

Nurit P. Azouz, Marc E. Rothenberg · 2019

Gastrointestinal (GI) allergic disease is an umbrella term used to describe a variety of adverse, food antigen-driven, immune-mediated diseases. Although these diseases vary mechanistically, common elements include a breakdown of immunolog…

Epithelial origin of eosinophilic esophagitis Open

Mark Rochman, Nurit P. Azouz, Marc E. Rothenberg · 2018

The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses Open

Nurit P. Azouz, Mario Alberto Ynga-Durand, Julie M. Caldwell, Ayushi Jain, Mark Rochman , et al. · 2018

Loss of esophageal SPINK7 unleashes protease activity, impairs barrier function, and induces proinflammatory responses.

The Anti-protease SPINK7 is a Checkpoint Regulator of Esophageal Epithelial Inflammatory Responses Open

Nurit P. Azouz, Mario Alberto Ynga-Durand, Julie M. Caldwell, Ayushi Jain, Mary C. Bedard , et al. · 2018

Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis Open

Ofir Klein, Amit Roded, Neta Zur, Nurit P. Azouz, Olga Pasternak , et al. · 2017

Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis Open

Mark Rochman, Jared Travers, Cora E. Miracle, Mary C. Bedard, Ting Wen , et al. · 2017

LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium Open

R D'mello, Julie M. Caldwell, Nurit P. Azouz, Ting Wen, Joseph D. Sherrill , et al. · 2015

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis Open

Nurit P. Azouz, Mitsunori Fukuda, Marc E. Rothenberg, Ronit Sagi‐Eisenberg · 2015

Mast Cells (MC) are secretory cells of the immune system that accomplish their physiological and pathological functions by releasing pre-formed and newly synthesized allergic, inflammatory and immunoregulatory mediators. MCs' mediators aff…

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