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View article: Insights into the computer-aided drug design and discovery based on anthraquinone scaffold for cancer treatment: A systematic review
Insights into the computer-aided drug design and discovery based on anthraquinone scaffold for cancer treatment: A systematic review Open
Background In the search for better anticancer drugs, computer-aided drug design (CADD) techniques play an indispensable role in facilitating the lengthy and costly drug discovery process especially when natural products are involved. Anth…
View article: The Analgesic Potential of Litsea Species: A Systematic Review
The Analgesic Potential of Litsea Species: A Systematic Review Open
Various plant species from the Litsea genus have been claimed to be beneficial for pain relief. The PRISMA approach was adopted to identify studies that reported analgesic properties of plants from the Litsea genus. Out of 450 records retu…
View article: Haematological, biochemical, and histopathological evaluation of the Morus alba L. leaf extract from Brunei Darussalam: Acute toxicity study in ICR mice
Haematological, biochemical, and histopathological evaluation of the Morus alba L. leaf extract from Brunei Darussalam: Acute toxicity study in ICR mice Open
Background: Studies have reported that the phytochemical content of Mulberry (Morus alba Linn.) is influenced by the area where it grows. On the other hand, the study of the bioactivity and toxicity of mulberry leaves from Brunei Darussala…
View article: Insights into the computer-aided drug design and discovery based on anthraquinone scaffold for cancer treatment: A protocol for systematic review
Insights into the computer-aided drug design and discovery based on anthraquinone scaffold for cancer treatment: A protocol for systematic review Open
There is still unmet medical need in cancer treatment mainly due to drug resistance and adverse drug events. Therefore, the search for better drugs is essential. Computer-aided drug design (CADD) and discovery tools are useful to streamlin…
View article: Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management
Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management Open
Obesity affects more than 10% of the adult population globally. Despite the introduction of diverse medications aimed at combating fat accumulation and obesity, a significant number of these pharmaceutical interventions are linked to subst…
View article: Prioritizing New Inhibitors for TPD1 from a Library of Anthraquinone and Chalcone Derivatives.
Prioritizing New Inhibitors for TPD1 from a Library of Anthraquinone and Chalcone Derivatives. Open
The main purpose of virtual screening is to rank order hit compounds according to their affinity to the protein target. Several functions and techniques have been developed to achieve this purpose; however, simple and forward methods were …
View article: Prioritizing New Inhibitors for TPD1 from a Library of Anthraquinone and Chalcone Derivatives.
Prioritizing New Inhibitors for TPD1 from a Library of Anthraquinone and Chalcone Derivatives. Open
The main purpose of virtual screening is to rank order hit compounds according to their affinity to the protein target. Several functions and techniques have been developed to achieve this purpose; however, simple and forward methods were …
View article: First national survey of medicine waste-minimizing ın Brunei Darussalam
First national survey of medicine waste-minimizing ın Brunei Darussalam Open
Medicine wastage has become a concern to the nation due to the detrimental impacts that it brings to the economy and environment.Therefore, this study aims to provide an overview of the various waste-minimizing activities performed by gove…
View article: Drug/Natural Products-Related problems in Elderly
Drug/Natural Products-Related problems in Elderly Open
Herbal remedies have risen for decades in developed and developing countries. In this systematic review, the herbs such as cannabis, St. John's wort, kava, turmeric, grapefruit, bitter orange, ginger, garlic, and Chinese Herbal tea are dis…
View article: Prevention and Treatment of Monkeypox: A Systematic Review of Preclinical Studies
Prevention and Treatment of Monkeypox: A Systematic Review of Preclinical Studies Open
The outbreak of monkeypox, coupled with the onslaught of the COVID-19 pandemic is a critical communicable disease. This study aimed to systematically identify and review research done on preclinical studies focusing on the potential monkey…
View article: Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives
Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives Open
Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the purported health benefits of chalcone and its derivatives, in…
View article: Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies Open
Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial …
View article: General Health Benefits and Pharmacological Activities of Triticum aestivum L.
General Health Benefits and Pharmacological Activities of Triticum aestivum L. Open
Common wheat (Triticum aestivum), one of the world’s most consumed cereal grains, is known for its uses in baking and cooking in addition to its medicinal uses. As this plant’s medical benefits are enormous and scattered, this narrative re…
View article: Coriandrum sativum L.:A review on ethnopharmacology, phytochemistry, and cardiovascular benefits
Coriandrum sativum L.:A review on ethnopharmacology, phytochemistry, and cardiovascular benefits Open
Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many ph…
View article: Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids?
Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids? Open
Since the commercialization of morphine in 1826, numerous alkaloids have been isolated and exploited effectively for the betterment of mankind, including cancer treatment. However, the commercialization of alkaloids as anticancer agents ha…
View article: Herbal Plants: The Role of AhR in Mediating Immunomodulation
Herbal Plants: The Role of AhR in Mediating Immunomodulation Open
The prevalence of chronic inflammatory diseases including inflammatory bowel disease (IBD), autoimmunity and cancer have increased in recent years. Herbal-based compounds such as flavonoids have been demonstrated to contribute to the modul…
View article: Overcoming Chemoresistance via Extracellular Vesicle Inhibition
Overcoming Chemoresistance via Extracellular Vesicle Inhibition Open
With the ever-growing number of cancer deaths worldwide, researchers have been working hard to identify the key reasons behind the failure of cancer therapies so the efficacy of those therapies may be improved. Based on extensive research …
View article: PREVALENCE OF UNCOLLECTED MEDICINES AT TWO HEALTH CENTERS IN BRUNEI
PREVALENCE OF UNCOLLECTED MEDICINES AT TWO HEALTH CENTERS IN BRUNEI Open
Objective: This study was designed to achieve a better knowledge of uncollected medicines at two health centers in Brunei.
Methods: Patients with prescriptions prepared at two community pharmacies but did not collect them within 1 week fr…
View article: Licorice: A Potential Herb in Overcoming SARS-CoV-2 Infections
Licorice: A Potential Herb in Overcoming SARS-CoV-2 Infections Open
The management of the global pandemic outbreak due to the coronavirus disease (COVID-19) has been challenging with no exact dedicated treatment nor established vaccines at the beginning of the pandemic. Nonetheless, the situation seems to …
View article: Phytochemical and Therapeutic Potential of <i>Citrus grandis</i> (L.) Osbeck: A Review
Phytochemical and Therapeutic Potential of <i>Citrus grandis</i> (L.) Osbeck: A Review Open
Citrus grandis or Citrus maxima, widely recognized as Pomelo is widely cultivated in many countries because of their large amounts of functional, nutraceutical and biological activities. In traditional medicine, various parts of this plant…
View article: Risk factors affecting COVID-19 case fatality rate: A quantitative analysis of top 50 affected countries
Risk factors affecting COVID-19 case fatality rate: A quantitative analysis of top 50 affected countries Open
Background: Latest clinical data on treatment on coronavirus disease 2019 (COVID-19) indicated that older patients and those with underlying history of smoking, hypertension or diabetes mellitus might have poorer prognosis of recovery from…
View article: Mobile Health Apps on COVID-19 Launched in the Early Days of the Pandemic: Content Analysis and Review
Mobile Health Apps on COVID-19 Launched in the Early Days of the Pandemic: Content Analysis and Review Open
Background Mobile health (mHealth) app use is a major concern because of the possible dissemination of misinformation that could harm the users. Particularly, it can be difficult for health care professionals to recommend a suitable app fo…
View article: Risk factors affecting COVID-19 case fatality rate: A quantitative analysis of top 50 affected countries
Risk factors affecting COVID-19 case fatality rate: A quantitative analysis of top 50 affected countries Open
Background Latest clinical data on treatment on coronavirus disease 2019 (COVID-19) indicated that older patients and those with underlying history of smoking, hypertension or diabetes mellitus might have poorer prognosis of recovery from …
View article: Mobile Health Apps on COVID-19 Launched in the Early Days of the Pandemic: Content Analysis and Review (Preprint)
Mobile Health Apps on COVID-19 Launched in the Early Days of the Pandemic: Content Analysis and Review (Preprint) Open
BACKGROUND Mobile health (mHealth) app use is a major concern because of the possible dissemination of misinformation that could harm the users. Particularly, it can be difficult for health care professionals to recommend a suitable app f…