Explanipedia

Development of a Competency Framework for Medical Affairs Professionals in Australasia Open

Andrew Weekes, Matthew Britland, Chitrarpita Saha, Simon McErlane, N. El Ansari , et al. · 2025

This framework has been endorsed by the Medical Affairs Professionals of Australasia Executive Committee and provides a clear framework for the professional development of medical affairs professionals across our region. It is also applica…

Effect of HER3 Overexpression on Survival Outcomes in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis Open

Masoud Hassanzadeh Makoui, Shiva Fekri, Zahra Jafari, Reza Hassanzadeh Makoui, N. El Ansari , et al. · 2025

In summary, our results reveal that a significant proportion of PC patients show overexpression of HER3, suggesting its potential role as a target for immunotherapy. The findings also highlight the promise of HER3 as a prognostic biomarker…

Acute Renal Failure with Severe Hyperkalaemia Revealing Schmidt Syndrome Open

Hassan Aden Neima, Sara Ijdda, Sana Rafi, G. El Mghari, N. El Ansari · 2025

Medicine

Schmidt's syndrome combines several autoimmune diseases, including Addison's disease, thyroiditis and peripheral gonadal insufficiency. A 21-year-old female presented 15 days prior to admission with a digestive complaint of nausea, vomitin…

Myxoedema Coma: A Rare Case Report Open

F. Ettalibi, S. Rafi, Sara Ijdda, G. El Mghari, N. El Ansari · 2025

Medicine Physics

Myxedema coma (MC) is a rare and life-threatening endocrine emergency resulting from severe hypothyroidism, with a high mortality rate. It can develop in patients with long-standing undiagnosed hypothyroidism or be precipitated by an under…

Molar Pregnancy Induced Hyperthyroidism: A Case Report Open

F. Ettalibi, S. Rafi, Sara Ijdda, G. El Mghari, N. El Ansari · 2025

Medicine Biology

Hyperthyroidism is a rare complication of gestational trophoblastic disease (GTD). Here, We report the case of a 20-year-old patient who presented with signs of hyperthyroidism during a molar pregnancy. The diagnosis was confirmed through …

Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: A Case Report Open

F. Ettalibi, S. Rafi, G. El Mghari, N. El Ansari · 2025

Medicine

Testicular Adrenal Rest Tumors (ISIT) are rare benign tumors observed in hormone adrénocorticotrope hypersecretion syndromes, particularly in congenital adrenal hyperplasia (CAH). They originate from aberrant adrenal cortical cells that de…

ENHANCING HYSTEROSALPINGOGRAPHY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS ON THE USE OF VIRTUAL REALITY OR MUSIC FOR REDUCING PAIN AND ANXIETY Open

Zainah Abdulbari Alhebshi, Shama Afroze Baig, Mubashshar Ahmad, Jumana H. Timraz, N. El Ansari , et al. · 2025

Psychology Medicine Biology

Background Hysterosalpingography (HSG) is a diagnostic procedure used to assess the uterus and fallopian tubes, often associated with pain and anxiety. This systematic review and meta-analysis evaluate the effectiveness of virtual reality …

Metastatic Medullary Thyroid Carcinoma: Current Situation and Outlook Open

F-Z. El Jaafari, Sara Ijdda, S. Rafi, G. El Mghari, N. El Ansari · 2025

Medicine Engineering

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid cancer, accounting for 1-2% of cases. While localized MTC has a good prognosis, metastatic MTC presents significant treatment challenges. This study explores diagnostic appr…

Refractory Hypocalcemia: A Case Report Open

F-Z. El Jaafari, S. Rafi, Sara Ijdda, G. El Mghari, N. El Ansari · 2025

Medicine Materials science

Introduction: Refractory hypocalcemia is a challenging condition that does not respond to standard treatment. One rare cause is malabsorption syndrome, which impairs the absorption of calcium and other nutrients. Patient and Methods: A 34-…

Unveiling the connection: asthma and endometriosis – a comprehensive systematic review and meta-analysis Open

Masoud Hassanzadeh Makoui, Shiva Fekri, Reza Hassanzadeh Makoui, N. El Ansari, Shima Shokrzadeh , et al. · 2025

Medicine Political science

Introduction and Objective: Asthma and endometriosis are two prevalent chronic conditions that affect a significant portion of the population. Both conditions have been linked to inflammatory processes and immune dysregulation, suggesting …

The Role of Mast Cells in the Development and Advancement of Endometriosis Open

Masoud Hassanzadeh Makoui, Shiva Fekri, Reza Hassanzadeh Makoui, N. El Ansari, Abdolreza Esmaeilzadeh · 2025

Biology Medicine

Endometriosis is a medical condition identified by the presence of endometrium‐like tissue outside the uterus. This condition is known to result in symptoms such as frequent pelvic pain, infertility, and irregularities in the menstrual cyc…

Sex Assignment in Cases of Ambiguous Genitalia Open

Hajira Mohammed, N. El Ansari, A. Baig, Joud J Alshowaikhat, Madiha M Uz Zama , et al. · 2024

Medicine

Ambiguous genitalia is a rare disorder where it is unclear whether an infant's external genitals are male or female. This can be attributed to various internal and external etiologies, such as androgen receptor abnormalities, gonadal abnor…

Exophthalmos Revealing Cushing’s Syndrome: A Case Report Open

Hassan Aden Neima, H. Salsabil, S. Rafi, G. El Mghari, N. El Ansari · 2024

Medicine

Exophthalmos is typically associated with Graves’ ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing’s syndrome. We present a case of a patient aged 40 years with no patholo…

Investigating the Co-Expression Rate of HER2 and HER3 Biomarkers in Cancer Patients: A Systematic Review and Meta-Analysis Open

Reza Hassanzadeh Makoui, Shiva Fekri, N. El Ansari, Masoud Hassanzadeh Makoui · 2024

Medicine Biology

The study found that HER2 and HER3 biomarkers, which are targets for different therapies, are co-expressed in various types of cancer.

Effects of bazedoxifene on endometriosis in experimental animal models: A systematic review and meta-analysis Open

Reza Hassanzadeh Makoui, Shiva Fekri, N. El Ansari, Masoud Hassanzadeh Makoui · 2024

Medicine Biology

Endometriosis is a prevalent condition in women that causes pelvic pain and fertility issues due to the growth of endometrial tissue outside the uterus during menstrual cycles. Steroid hormones play a crucial role in the development and gr…

Correlation between the existence of serum autoantibodies and the risk of endometriosis: A systematic review and meta-analysis Open

Shiva Fekri, Reza Hassanzadeh Makoui, N. El Ansari, Masoud Hassanzadeh Makoui · 2024

Medicine

Endometriosis is a common condition among women and can cause complications such as abdominal pain, dysmenorrhea, and infertility. One of the potential causes of this disease is autoimmunity. However, evidence regarding the role of autoimm…

Individual effects of GSTM1 and GSTT1 polymorphisms on the risk of polycystic ovarian syndrome: A systematic review and meta-analysis Open

Masoud Hassanzadeh Makoui, Shiva Fekri, Reza Hassanzadeh Makoui, N. El Ansari · 2023

Medicine Biology

This study aimed to understand the relationship between two specific genetic variations (GSTT1 and GSTM1 polymorphisms) and the risk of developing polycystic ovarian syndrome (PCOS). PCOS is a common endocrinologic disorder that affects wo…

Simultaneous Thyroid Autoimmunity: A Coexistence of Grave's Disease and Hashimoto's Thyroiditis Open

H. Ouakrim, I. Midhat, S. Rafi, G. El Mghari, N. El Ansari · 2023

Medicine

Introduction: Grave’s Disease (GD) and Hashimoto's Thyroiditis (HT) are two autoimmune diseases whose coexistence is rare. We report a case of a patient in whom both diseases manifested simultaneously. Case report: A 36- year-old woman pre…

Rare Localization of Papillary Thyroid Carcinoma on Thyroglossal Tract Cyst Open

Sara Ijdda, S. Rafi, G.H. Elmghari, N. El Ansari · 2023

Medicine

Thyroglossal tract cysts (TTCs) are common and degeneration is rare, occurring in only around 1 to 1.5 % of cases. Papillary carcinoma is the most common histological type. The clinical presentation of these cancers is very often non-speci…

Hyperthyroidism and Pregnancy Open

Sara Ijdda, S. Rafi, G.H. Elmghari, N. El Ansari · 2023

Medicine Biology

Introduction: Hyperthyroidism in pregnancy is defined by low TSH, below the specific reference values of each trimester with high levels of free T3, free T4 or both. Source of serious complications for both the mother and the fetus. The ai…

A rare case of Cushing syndrome ectopic-ACTH: A case report Open

Hassan Aden Neima, S. Bammou, S RAFI, G. El Mghari, N. El Ansari · 2023

Medicine

Malignant tumors, nevertheless, have been associated with extremely high circulating ACTH and cortisol levels, and short duration of symptoms of Cushing syndrome (CS) besides atypical clinical phenotype, when compared with pituitary-depend…

A rare case of Cushing syndrome ectopic-ACTH: A case report Open

Hassan Aden Neima, S. Bammou, S RAFI, G. El Mghari, N. El Ansari · 2023

Medicine

Malignant tumors, nevertheless, have been associated with extremely high circulating ACTH and cortisol levels, and short duration of symptoms of Cushing syndrome (CS) besides atypical clinical phenotype, when compared with pituitary-depend…

46 XY disorder of sex development: Case report Open

F. El Gharroudi, S. Bammou, S. Rafi, G. El Mghari, N. El Ansari · 2023

Psychology

Disorders of sexual differentiation in 46, XY patients cover a wide spectrum of clinical pictures (female phenotype, posterior hypospadias, cryptorchidism). Their causes are varied and affect the stages of testicular determination (gonadal…

Bilateral pheochromocytoma: A case report Open

M. Ben lafqih, N. Hassan Aden, S. Rafi, G. El Mghari, N. El Ansari · 2023

Medicine

Pheochromocytoma is a rare tumor developed at the expense of chromaffin cells, the adrenal involvement is most often unilateral. But, in 10% of cases, a bilateral localization is observed. We report the case of a 62-year-old patient, witho…

Spontaneous reduction in macroprolactinoma volume during pregnancy and after birth: A case report Open

F El Gharroudi, S. Rafi, G. El Mghari, N. El Ansari · 2023

Medicine Mathematics Physics

Prolactinoma, the most common secretory pituitary tumor, is found in 100 patients per million. It is responsible for impaired reproductive function in both sexes. Its treatment in the context of fertility restoration gives very satisfactor…

Pituitary macro adenoma presenting as severe hyponatremia: A case report Open

M. Ben Lafqih, I. Bouizamarane, W. Douali, S. Rafi, G. El Mghari , et al. · 2022

Medicine Computer science

Hyponatremia in panhypopituitarism is multifactorial, it can be explained by the corticotropic deficit observed in pituitary insufficiency which is responsible for a lifting of inhibition on the anti-diuretic hormone with a consequent net …

THE IMPACT OF RAMADAN FASTING ON LEAN BODY MASSOF TYPE 2 DIABETICS Open

Widad. Douali, Farah Elgharroudi, S. Rafi, G.El. Mghari, N. El Ansari , et al. · 2022

Medicine

Introduction:Despitebeing exempt, manyDiabeticMuslims observe fastingduring the month of Ramadan. Wecarried out thiswork to study the impact of this practice Lean body mass in this group of patients. Material and methods:Westudied 176 Moro…

Insulin Injection A Non-Trivial Act with Sometimes Serious Consequences: Major Role of Therapeutic Education Open

Rolly Junior Louzolo-Kimbembe, F-Z. El Jaafari, S. Rafi, G. El Mghari, N. El Ansari · 2021

Medicine

Case ReportInsulin, the more powerful antihyperglycemic agent, is the most widely used treatment in the management of diabetes mellitus.This product has undergone several developments since its invention, basically with the modification of…

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