Nuzhat Husain
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View article: Tumors and tumor-like lesions of the gall bladder—A review
Tumors and tumor-like lesions of the gall bladder—A review Open
Gall bladder carcinoma (GBC) remains a formidable diagnostic and therapeutic challenge, characterized by its often-incidental discovery and diverse spectrum of lesions, spanning from benign mimickers to malignant neoplasms. This review syn…
View article: A Pan-Indian survey on the interpretation of intestinal biopsies in inflammatory bowel disease, and differentiating intestinal tuberculosis and Crohn’s disease from a pathologist’s perspective
A Pan-Indian survey on the interpretation of intestinal biopsies in inflammatory bowel disease, and differentiating intestinal tuberculosis and Crohn’s disease from a pathologist’s perspective Open
Background: The incidence of inflammatory bowel disease (IBD) is rising in India, particularly that of Crohn’s disease (CD). Histological examination is essential for disease evaluation. Materials and Methods: This national survey invited …
View article: Circulating tumor cells in liquid biopsy: progress and challenges in detection and quantification
Circulating tumor cells in liquid biopsy: progress and challenges in detection and quantification Open
Circulating tumor cells (CTCs) are extremely rare in peripheral blood, typically occurring at a frequency of approximately one cell per million to ten million nucleated blood cells. This rarity presents significant challenges for their det…
View article: Amyloidogenic occipital mass obscuring plasmacytoma: a rare presentation and review of literature
Amyloidogenic occipital mass obscuring plasmacytoma: a rare presentation and review of literature Open
Solitary plasmacytoma of bone are a spectrum of plasma cell disorder which are defined by presence of clonal plasma cell in the bone including skull. The occurrence of true plasmacytoma of skull with large amyloid deposits in young patient…
View article: Pattern of care and clinical outcome of patients with carcinoma endometrium and the impact of central histopathological review on management: A tertiary cancer centre experience
Pattern of care and clinical outcome of patients with carcinoma endometrium and the impact of central histopathological review on management: A tertiary cancer centre experience Open
Purpose/Objective: Endometrial carcinoma (EC) is the third most common gynecological malignancy in India. Recent PORTEC-3 analysis emphasized the role of central histopathological review. We aimed to retrospectively analyze the demographic…
View article: Panel of serum long non-coding RNAs as potential non-invasive biomarkers for gallbladder carcinoma
Panel of serum long non-coding RNAs as potential non-invasive biomarkers for gallbladder carcinoma Open
Gallbladder carcinoma (GBC) is a common malignancy and is usually diagnosed in the late stages of the disease. The identification of new effective early diagnostic biomarkers could represent an effective approach in reducing mortality in G…
View article: Covid-19-Associated Mucormycosis: Histopathology of the Deadly Fungal Infection
Covid-19-Associated Mucormycosis: Histopathology of the Deadly Fungal Infection Open
Introduction Many patients suffered from rhino-orbital-cerebral mucormycosis during the coronavirus disease 2019 (COVID-19) pandemic in India. Diabetes is a known risk factor of COVID-19 infection and mucormycosis. Objective The present st…
View article: A study on expression of programmed death ligand-1in small cell lung carcinoma and correlation withclinicopathological parameters
A study on expression of programmed death ligand-1in small cell lung carcinoma and correlation withclinicopathological parameters Open
Small cell lung carcinoma (SCLC) is characterized by rapid growth and an aggressive clinical course. Standard therapy regimes have limited effects on disease course; therefore the prognosis of SCLC is poor. In the current study, the freque…
View article: Parathyroid carcinoma in a patient with primary hyperparathyroidism mimicking parathyroid adenoma
Parathyroid carcinoma in a patient with primary hyperparathyroidism mimicking parathyroid adenoma Open
Primary hyperparathyroidism caused by parathyroid carcinoma is extremely rare. Clinically, it is very challenging to differentiate between parathyroid carcinoma and adenoma. The correct diagnosis is made based on the histopathology of the …
View article: 471 Accuracy of Preoperative MRI for Rectal Cancer: A Retrospective Study at a District General Hospital
471 Accuracy of Preoperative MRI for Rectal Cancer: A Retrospective Study at a District General Hospital Open
Aim To investigate the accuracy of preoperative MRI for rectal cancer in the form of sensitivity, specificity, positive predictive value and negative predictive value. Method The retrospective study included a cohort of 47 patients of rect…
View article: Circulating free DNA integrity index and promoter methylation of tumor suppressor gene P16, DAPK and RASSF1A as a biomarker for oropharyngeal squamous cell carcinoma
Circulating free DNA integrity index and promoter methylation of tumor suppressor gene P16, DAPK and RASSF1A as a biomarker for oropharyngeal squamous cell carcinoma Open
Circulating free DNA (cfDNA) is in use for the non-invasive diagnosis of tumors. Methylation of tumor suppressor genes (TSGs) is an early event in carcinogenesis and may serve as tumor biomarker. We have investigated cfDNA integrity and me…
View article: Immunophenotypic characterization of normal and abnormal plasma cells in bone marrow of newly diagnosed multiple myeloma patients
Immunophenotypic characterization of normal and abnormal plasma cells in bone marrow of newly diagnosed multiple myeloma patients Open
Background: Identification of plasma cells into abnormal (APC) and normal (NPC) compartments is of utmost importance in flow cytometric (FC) analysis of multiple myeloma (MM) and related plasma cell dyscrasias for diagnosis, prognosis, and…
View article: Detection of IDH1 Mutation in cfDNA and Tissue of Adult Diffuse Glioma with Allele-Specific qPCR
Detection of IDH1 Mutation in cfDNA and Tissue of Adult Diffuse Glioma with Allele-Specific qPCR Open
The CAST-PCR assay is more precise and sensitive for IDH1-R132Hdetection than traditional IHC, and IDH1-R132H mutation detection using cfDNA may add to the current methods of glioma genomic characterization.
View article: Ewing’s sarcoma of the right kidney with multiple metastasis on PET/CT
Ewing’s sarcoma of the right kidney with multiple metastasis on PET/CT Open
Background Ewing’s sarcoma is categorized as small round cell aggressive tumor which commonly occurs in bone and soft tissue. Primary renal Ewing’s sarcoma is an extremely rare entity and accounts for less than 1% of renal masses. It is ch…
View article: Ovarian hydatid cyst: an uncommon site of presentation
Ovarian hydatid cyst: an uncommon site of presentation Open
Hydatid cyst is a parasitic infestation caused by Echinococcus larvae. Hydatid cyst of the ovary is a highly unusual presentation. Herein, we present a case of a young woman who complained of episodic lower abdominal pain. Ultrasound of th…
View article: Anorectal balloon cell melanoma: a rare variant
Anorectal balloon cell melanoma: a rare variant Open
Balloon cell melanoma is a rare presentation of malignant melanoma, usually on the skin, with less than 100 cases reported. Mucosal BCM is even rarer, with only one case of anorectal BCM reported in English literature. The diagnosis is bas…
View article: Evaluation of PDL-1 expression in thyroid carcinoma and its correlation with clinicopathological parameters in a North Indian population
Evaluation of PDL-1 expression in thyroid carcinoma and its correlation with clinicopathological parameters in a North Indian population Open
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View article: Cytomorphology of pituitary carcinoma metastatic to liver diagnosed by fine-needle aspiration: A rare case report and review of literature
Cytomorphology of pituitary carcinoma metastatic to liver diagnosed by fine-needle aspiration: A rare case report and review of literature Open
Pituitary carcinomas (PCs) are rare entities constituting about 0.1–0.2% of all pituitary neoplasms. They are diagnosed by the presence of craniospinal or systemic metastasis in pituitary adenomas (PAs). The distant metastatic sites includ…
View article: Crossing Vessel in Pelvi Ureteric Junction Obstruction: A Histopathological Analysis
Crossing Vessel in Pelvi Ureteric Junction Obstruction: A Histopathological Analysis Open
The differences in histopathological examination between the 2 groups were not statistically significant. However, in patients with crossing vessels, there was a higher degree of inflammation, which may lead to early pelvi ureteric junctio…
View article: Medical Thoracoscopy: A Useful Diagnostic Tool for Undiagnosed Pleural Effusion
Medical Thoracoscopy: A Useful Diagnostic Tool for Undiagnosed Pleural Effusion Open
Medical thoracoscopy is a useful tool for the diagnosis of pleural diseases. The procedure is safe with minimal complications.
View article: Laboratory perspectives for Leprosy: Diagnostic, prognostic and predictive tools.
Laboratory perspectives for Leprosy: Diagnostic, prognostic and predictive tools. Open
The diagnosis of leprosy poses several challenges. The bacillary load, serology, and tissue response are determined by the host immune status, which make individual tests unsuitable across the spectrum. The sensitivity of tests for identif…
View article: Liquid biopsy in CNS tumors: Current status & future perspectives.
Liquid biopsy in CNS tumors: Current status & future perspectives. Open
Precise classification of central nervous system (CNS) malignancies is vital for the treatment and prognostication. Identification of noninvasive markers can be of importance to guide treatment decisions and in monitoring treatment respons…