Nyengo Mkandawire
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View article: A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival
A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival Open
View article: Injury: a neglected global health challenge in low-income and middle-income countries
Injury: a neglected global health challenge in low-income and middle-income countries Open
View article: Technical Priorities for Orthopaedic Trauma Care Development in Malawi
Technical Priorities for Orthopaedic Trauma Care Development in Malawi Open
Introduction Malawi has a high and rising incidence of musculoskeletal injuries and inadequate orthopaedic trauma care capacity, which must be urgently addressed. MethodsWe performed a scoping literature review to define essential goals an…
View article: Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma
Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma Open
View article: Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa Open
In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in s…
View article: Sickle cell allele <scp><i>HBB</i></scp>‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa
Sickle cell allele <span><i>HBB</i></span>‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa Open
Burkitt lymphoma (BL) is an aggressive B‐cell lymphoma that significantly contributes to childhood cancer burden in sub‐Saharan Africa. Plasmodium falciparum , which causes malaria, is geographically associated with BL, but the evidence re…
View article: The Socioeconomic consequences of femoral shaft fracture for patients in Malawi
The Socioeconomic consequences of femoral shaft fracture for patients in Malawi Open
BackgroundFemoral shaft fractures are common in Malawi, with an annual incidence of 44 per 100,000 people. Inadequate treatment and delayed presentation often result in functional, biopsychosocial, and financial challenges for patients. Th…
View article: Outcomes of open tibial fracture surgery: beyond the operating room
Outcomes of open tibial fracture surgery: beyond the operating room Open
Musculoskeletal injuries are a global issue and a particular challenge in low-income countries, owing to the rising rates of road traffic injuries and rudimentary trauma care systems.1 The tibia is the bone that most frequently sustains an…
View article: <i>IFNL4</i> Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa
<i>IFNL4</i> Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa Open
Interferon lambda 4 (IFN-λ4) is a novel type-III interferon that can be expressed only by carriers of the genetic variant rs368234815-dG within the first exon of the IFNL4 gene. Genetic inability to produce IFN-λ4 (in carriers of th…
View article: GENOME‐WIDE ASSOCIATION STUDY OF CHILDHOOD BURKITT LYMPHOMA IN EAST AFRICA IDENTIFIES A NOVEL GERMLINE SUSCEPTIBILITY LOCUS ON CHROMOSOME 21
GENOME‐WIDE ASSOCIATION STUDY OF CHILDHOOD BURKITT LYMPHOMA IN EAST AFRICA IDENTIFIES A NOVEL GERMLINE SUSCEPTIBILITY LOCUS ON CHROMOSOME 21 Open
Introduction: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with hallmark somatic IG::MYC chromosomal translocations. BL is responsible for a significant proportion of childhood cancers in equatorial Africa, where exposure to Epst…
View article: Surgical capacity, productivity and efficiency at the district level in Sub-Saharan Africa: A three-country study
Surgical capacity, productivity and efficiency at the district level in Sub-Saharan Africa: A three-country study Open
Introduction Efficient utilisation of surgical resources is essential when providing surgical care in low-resources settings. Countries are developing plans to scale up surgery, though insufficiently based on empirical evidence. This paper…
View article: The presence and availability of essential diagnostics in Malawian district and central hospitals: A secondary analysis of a nationwide survey of musculoskeletal trauma care capacity
The presence and availability of essential diagnostics in Malawian district and central hospitals: A secondary analysis of a nationwide survey of musculoskeletal trauma care capacity Open
Background Diagnostics are foundational to effective health systems but remain widely unavailable worldwide, especially in low-income countries like Malawi. To achieve health equity in Malawi, it is necessary to assess the availability of…
View article: Starting a spine surgery service in a low-resource setting: a look back over twenty five years of spine surgery in Malawi
Starting a spine surgery service in a low-resource setting: a look back over twenty five years of spine surgery in Malawi Open
Purpose This is a short historical narrative of the development of spine surgery in Malawi. Methods The authors communicated and both drew on memories and anecdotes over the last 25 years. Results This is not a scientific paper, so there a…
View article: The unmet need for treatment of children with musculoskeletal impairment in Malawi
The unmet need for treatment of children with musculoskeletal impairment in Malawi Open
View article: Additional file 1 of The unmet need for treatment of children with musculoskeletal impairment in Malawi
Additional file 1 of The unmet need for treatment of children with musculoskeletal impairment in Malawi Open
Additional file 1. Appendix: Rapid Assessment of Musculoskeletal Impairment (RAM 1 & RAM 2).
View article: The experiences of adult patients receiving treatment for femoral shaft fractures at a public referral hospital in Lilongwe, Malawi: A qualitative analysis
The experiences of adult patients receiving treatment for femoral shaft fractures at a public referral hospital in Lilongwe, Malawi: A qualitative analysis Open
Background: Malawi has a rising burden of musculoskeletal trauma, coupled with insufficient surgical capacity to manage common, debilitating injuries like femoral shaft fractures. Nonoperative treatment remains the standard of care, with s…
View article: Total Joint Arthroplasty in HIV-Positive Patients in Malawi
Total Joint Arthroplasty in HIV-Positive Patients in Malawi Open
Background: In this observational study, we describe the medium-term outcomes of total joint arthroplasty (TJA) in human immunodeficiency virus (HIV)-positive patients in Malawi, a low-income country. With a high prevalence of HIV and incr…
View article: Improving Access to Surgery Through Surgical Team Mentoring – Policy Lessons From Group Model Building With Local Stakeholders in Malawi
Improving Access to Surgery Through Surgical Team Mentoring – Policy Lessons From Group Model Building With Local Stakeholders in Malawi Open
To sustain surgical mentoring, it is important that an approach of continued communication, monitoring, and (re-)evaluation is taken. In addition, an output- or performance-based financing scheme for DHs is required to incentivize them to …
View article: Paediatric surgical conditions in Malawi - A cross-sectional nationwide household survey
Paediatric surgical conditions in Malawi - A cross-sectional nationwide household survey Open
BackgroundUntreated surgical conditions may lead to lifelong disability in children. Treating children with surgical conditions may reduce long-term effects of morbidity and disability. Unfortunately, low- and middle-income countries have …
View article: The unmet need for treatment of children with musculoskeletal impairment in Malawi
The unmet need for treatment of children with musculoskeletal impairment in Malawi Open
Background More than a billion people globally are living with disability and the prevalence is likely to increase rapidly in the coming years in low- and middle-income countries (LMICs). The vast majority of those living with disability a…
View article: Assessment of Mixed Plasmodium falciparum sera5 Infection in Endemic Burkitt Lymphoma: A Case-Control Study in Malawi
Assessment of Mixed Plasmodium falciparum sera5 Infection in Endemic Burkitt Lymphoma: A Case-Control Study in Malawi Open
Background: Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in Africa and is linked to Plasmodium falciparum (Pf) malaria infection, one of the most common and deadly childhood infections in Africa; however, the role of …
View article: Cost utility analysis of intramedullary nailing and skeletal traction treatment for patients with femoral shaft fractures in Malawi
Cost utility analysis of intramedullary nailing and skeletal traction treatment for patients with femoral shaft fractures in Malawi Open
Background and purpose - In Malawi, both skeletal traction (ST) and intramedullary nailing (IMN) are used in the treatment of femoral shaft fractures, ST being the mainstay treatment. Previous studies have found that IMN has improved outco…
View article: Surgical service monitoring and quality control systems at district hospitals in Malawi, Tanzania and Zambia: a mixed-methods study
Surgical service monitoring and quality control systems at district hospitals in Malawi, Tanzania and Zambia: a mixed-methods study Open
Background In low-income and middle-income countries, an estimated one in three clinical adverse events happens in non-complex situations and 83% are preventable. Poor quality of care also leads to inefficient use of human, material and fi…
View article: Prevalence, causes and impact of musculoskeletal impairment in Malawi: A national cluster randomized survey
Prevalence, causes and impact of musculoskeletal impairment in Malawi: A national cluster randomized survey Open
Background There is a lack of accurate information on the prevalence and causes of musculoskeletal impairment (MSI) in low income countries. The WHO prevalence estimate does not help plan services for specific national income levels or cou…
View article: Total Joint Arthroplasty in HIV-Positive Patients in Malawi
Total Joint Arthroplasty in HIV-Positive Patients in Malawi Open
In this observational study, we describe the medium-term outcomes of total joint arthroplasty (TJA) in human immunodeficiency virus (HIV)-positive patients in Malawi, a low-income country. With a high prevalence of HIV and increasing arthr…
View article: Improving Management of Adult Ankle Fractures in Malawi
Improving Management of Adult Ankle Fractures in Malawi Open
Background: The burden of musculoskeletal trauma is increasing worldwide, especially in low-income countries such as Malawi. Ankle fractures are common in Malawi and may receive suboptimal treatment due to inadequate surgical capacity and …
View article: A nationwide survey investigating the prevalence and incidence of adults with femoral shaft fractures receiving care in Malawian district and central hospitals
A nationwide survey investigating the prevalence and incidence of adults with femoral shaft fractures receiving care in Malawian district and central hospitals Open
Background: Diaphyseal femoral fractures are a common musculoskeletal injury in Malawi, often due to road traffic collisions. Most adults are treated non-operatively as inpatients, occupying limited beds for up to 2 months. We sought to do…
View article: Improving the Management of Adult Patients with Acute Ankle Fractures in Malawi: An Examination of Providers’ Knowledge and Treatment Strategies
Improving the Management of Adult Patients with Acute Ankle Fractures in Malawi: An Examination of Providers’ Knowledge and Treatment Strategies Open
Category: Trauma; Ankle; Other Introduction/Purpose: The burden of trauma is growing worldwide, especially in low-income countries. In Malawi, ankle fractures are common and may receive inadequate treatment due to limited surgical capacity…
View article: Deaths from surgical conditions in Malawi - a randomised cross-sectional Nationwide household survey
Deaths from surgical conditions in Malawi - a randomised cross-sectional Nationwide household survey Open
View article: Outcome at 1 year in patients with femoral shaft fractures treated with intramedullary nailing or skeletal traction in a low-income country: a prospective observational study of 187 patients in Malawi
Outcome at 1 year in patients with femoral shaft fractures treated with intramedullary nailing or skeletal traction in a low-income country: a prospective observational study of 187 patients in Malawi Open
Background and purpose - Intramedullary nailing (IMN) is underutilized in low-income countries (LICs) where skeletal traction (ST) remains the standard of care for femoral shaft fractures. This prospective study compared patient-reported q…