A. Osama Gaber
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View article: CHL1 Regulates Cortical Neuron Identity and Laminar Formation during Stem Cell-derived Neurogenesis
CHL1 Regulates Cortical Neuron Identity and Laminar Formation during Stem Cell-derived Neurogenesis Open
Background: Close Homolog of L1 (CHL1), a neural cell adhesion molecule, plays a critical role in cortical development, but its isoform-specific and stage-dependent functions remain poorly defined. This study examines the differential effe…
View article: Tannic acid nanoparticles improve the renal histological structure and kidney function in arsenic trioxide-induced renal damage
Tannic acid nanoparticles improve the renal histological structure and kidney function in arsenic trioxide-induced renal damage Open
View article: Pro-inflammatory Cytokines of Gastric Tissues and Its Role in Patients with H. pylori
Pro-inflammatory Cytokines of Gastric Tissues and Its Role in Patients with H. pylori Open
View article: Long-term outcomes of light chain amyloidosis patients receiving heart transplant: A single-center experience
Long-term outcomes of light chain amyloidosis patients receiving heart transplant: A single-center experience Open
View article: Osteocalcin induces phosphorylation of FOXO1 in human beta-cells and restores insulin expression under hyperglycemic conditions
Osteocalcin induces phosphorylation of FOXO1 in human beta-cells and restores insulin expression under hyperglycemic conditions Open
Forkhead box O1 (FOXO1) is a key transcription factor that plays an important role in pancreatic β-cell compensation under physiological and pathological conditions and serves as a key regulator of glucose homeostasis. While FOXO1 expressi…
View article: Impact of Therapeutic Plasma Exchange and Rituximab for Prevention of Idiopathic Focal Segmental Glomerulosclerosis Recurrence Post–Kidney Transplantation
Impact of Therapeutic Plasma Exchange and Rituximab for Prevention of Idiopathic Focal Segmental Glomerulosclerosis Recurrence Post–Kidney Transplantation Open
Background. Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation (KT) in 30%–50% of recipients. Recurrence is associated with early graft loss in up to 60% of cases. This study aimed to assess the efficacy of thera…
View article: Neoadjuvant Multiagent Systemic Therapy Approach to Liver Transplantation for Perihilar Cholangiocarcinoma
Neoadjuvant Multiagent Systemic Therapy Approach to Liver Transplantation for Perihilar Cholangiocarcinoma Open
Background. Perihilar cholangiocarcinoma (phCCA) has excellent outcomes following liver transplantation (LT). Neoadjuvant radiation-based locoregional therapy is standard-of-care. Gemcitabine and cisplatin (gem/cis) combination systemic th…
View article: A systematic review of progress test as longitudinal assessment in Saudi Arabia
A systematic review of progress test as longitudinal assessment in Saudi Arabia Open
View article: The learning curve for robotic living donor right hepatectomy: Analysis of outcomes in 2 specialized centers
The learning curve for robotic living donor right hepatectomy: Analysis of outcomes in 2 specialized centers Open
Robotic surgery is an emerging minimally invasive option for living donor hepatectomy. Currently, there are no studies on the learning curve of robotic donor hepatectomy. Thus, we evaluated the learning curve for robotic donor right hepate…
View article: Determining Predictors of Actual Living Kidney Donation Based on Potential Donor Characteristics
Determining Predictors of Actual Living Kidney Donation Based on Potential Donor Characteristics Open
Background Living donor kidney transplantation is the optimal treatment for end‐stage kidney disease; however, few living donor candidates (LDCs) who begin evaluation actually donate. While some LDCs are deemed medically ineligible, others…
View article: Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization
Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization Open
Background. The COVID-19 pandemic has led to an increase in SARS-CoV-2–test positive potential organ donors. The benefits of life-saving liver transplantation (LT) must be balanced against the potential risk of donor-derived viral transmis…
View article: CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4+ T cell immunity is dependent on an intrinsic stem-like program Open
View article: Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant
Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant Open
Significance Statement There is no standardized desensitization regimen for kidney transplant candidates. CD38, expressed by plasma cells, could be targeted for desensitization to deplete plasma cells producing alloantibodies and donor-spe…
View article: Transplant Oncology: An Emerging Discipline of Cancer Treatment
Transplant Oncology: An Emerging Discipline of Cancer Treatment Open
Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The applications of oncology, transplant medicine, and surgery are the core of transplant oncology to improve patients’ survival and quali…
View article: Qualifying a Novel Clinical Trial Endpoint (iBOX) Predictive of Long-Term Kidney Transplant Outcomes
Qualifying a Novel Clinical Trial Endpoint (iBOX) Predictive of Long-Term Kidney Transplant Outcomes Open
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute’s Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel sec…
View article: Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients
Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients Open
Older compatible living donor kidney transplant (CLDKT) recipients have higher mortality and death-censored graft failure (DCGF) compared to younger recipients. These risks may be amplified in older incompatible living donor kidney transpl…
View article: Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes
Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes Open
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute's Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel sec…
View article: Longitudinal estimated glomerular filtration rate (<scp>eGFR)</scp> modeling in long‐term renal function to inform clinical trial design in kidney transplantation
Longitudinal estimated glomerular filtration rate (<span>eGFR)</span> modeling in long‐term renal function to inform clinical trial design in kidney transplantation Open
Kidney transplantation is the preferred treatment for individuals with end‐stage kidney disease. From a modeling perspective, our understanding of kidney function trajectories after transplantation remains limited. Current modeling of kidn…
View article: #6389 EARLY WEIGHT LOSS AFTER BARIATRIC SURGERY IN PATIENTS WITH ORGAN FAILURE OR TRANSPLANTATION
#6389 EARLY WEIGHT LOSS AFTER BARIATRIC SURGERY IN PATIENTS WITH ORGAN FAILURE OR TRANSPLANTATION Open
Background and Aims Obesity is an epidemic that complicates global health and economies. Surgery for obesity (OS) is one effective treatment that results in significant weight loss. Patients with chronic organ failure who are obese undergo…
View article: Factors affecting survival after liver retransplantation: a systematic review and meta-analysis
Factors affecting survival after liver retransplantation: a systematic review and meta-analysis Open
Background Liver retransplantation (reLT) has historically had inferior survival relative to primary liver transplant (LT). To improve outcomes after reLT, researchers have identified factors predicting overall (OS) and/or graft survival (…
View article: Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry
Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry Open
View article: Progress in Combined Liver–lung Transplantation at a Single Center
Progress in Combined Liver–lung Transplantation at a Single Center Open
Background. Combined liver–lung transplantation is an uncommon, although vital, procedure for patients with simultaneous end-stage lung and liver disease. The utility of lung–liver transplant has been questioned because of initial poor sur…
View article: Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats Open
View article: COVID-19 mortality may be reduced among fully vaccinated solid organ transplant recipients
COVID-19 mortality may be reduced among fully vaccinated solid organ transplant recipients Open
Background Solid organ transplant (SOT) recipients are at increased risk for morbidity and mortality from COVID-19 due to their immunosuppressed state and reduced immunogenicity from COVID-19 mRNA vaccines. This investigation examined the …
View article: Hospitalization and survival of solid organ transplant recipients with coronavirus disease 2019: A propensity matched cohort study
Hospitalization and survival of solid organ transplant recipients with coronavirus disease 2019: A propensity matched cohort study Open
Background Solid organ transplant (SOT) recipients are predicted to have worse COVID-19 outcomes due to their compromised immunity. However, this association remains uncertain because published studies have had small sample sizes and varia…
View article: Pretransplant HOMA-β Is Predictive of Insulin Independence in 7 Patients With Chronic Pancreatitis Undergoing Islet Autotransplantation
Pretransplant HOMA-β Is Predictive of Insulin Independence in 7 Patients With Chronic Pancreatitis Undergoing Islet Autotransplantation Open
Background. Islet and β-cell function is intrinsic to glucose homeostasis. Pancreatectomy and islet autotransplantation (PIAT) for chronic pancreatitis (CP) treatment is a useful model for assessing islet function in the absence of immune-…
View article: B-cell response in solid organ transplantation
B-cell response in solid organ transplantation Open
The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, i…
View article: mTOR inhibitors, mycophenolates, and other immunosuppression regimens on antibody response to SARS-CoV-2 mRNA vaccines in solid organ transplant recipients
mTOR inhibitors, mycophenolates, and other immunosuppression regimens on antibody response to SARS-CoV-2 mRNA vaccines in solid organ transplant recipients Open
View article: Predicting a Positive Antibody Response After 2 SARS-CoV-2 mRNA Vaccines in Transplant Recipients: A Machine Learning Approach With External Validation
Predicting a Positive Antibody Response After 2 SARS-CoV-2 mRNA Vaccines in Transplant Recipients: A Machine Learning Approach With External Validation Open
Background. Solid organ transplant recipients (SOTRs) are less likely to mount an antibody response to SARS-CoV-2 mRNA vaccines. Understanding risk factors for impaired vaccine response can guide strategies for antibody testing and additio…
View article: Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View
Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View Open
Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related deaths and accounts for over eighty percent of primary liver cancers worldwide. Surgical resection and radiofrequency ablation in small tumors are inc…