Oliver Artz
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View article: Acquired High Tumor Mutational Burden and Activity of Immunotherapy after Targeted Therapy in Microsatellite Stable Colorectal Cancer
Acquired High Tumor Mutational Burden and Activity of Immunotherapy after Targeted Therapy in Microsatellite Stable Colorectal Cancer Open
Purpose: Microsatellite stable (MSS) colorectal cancers, in contrast to microsatellite instability–high colorectal cancers, have few mutations and are insensitive to immune checkpoint blockade (ICB). Colorectal cancers treated with targete…
View article: Nonoperative Management of Mismatch Repair–Deficient Tumors
Nonoperative Management of Mismatch Repair–Deficient Tumors Open
Among patients with early-stage dMMR solid tumors that were amenable to curative-intent surgery, neoadjuvant PD-1 blockade led to organ preservation in a high proportion of patients. (Funded by Swim Across America and others; ClinicalTrial…
View article: The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer
The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer Open
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes and plays a key role in cellular growth and development. Global changes in cellular methylated RNA and m6A-mediated transcript regulation significantly i…
View article: Data from Analysis of Shared Variants between Cancer Biospecimens
Data from Analysis of Shared Variants between Cancer Biospecimens Open
Purpose:Mutational data from multiple solid and liquid biospecimens of a single patient are often integrated to track cancer evolution. However, there is no accepted framework to resolve if individual samples from the same individual share…
View article: Supplementary Methods1 from Analysis of Shared Variants between Cancer Biospecimens
Supplementary Methods1 from Analysis of Shared Variants between Cancer Biospecimens Open
Supplementary Methods
View article: Supplementary Figures and Tables1 from Analysis of Shared Variants between Cancer Biospecimens
Supplementary Figures and Tables1 from Analysis of Shared Variants between Cancer Biospecimens Open
Supplementary Figures and Supplementary Table Headings
View article: Supplementary Tables1 from Analysis of Shared Variants between Cancer Biospecimens
Supplementary Tables1 from Analysis of Shared Variants between Cancer Biospecimens Open
Supplementary Table Data
View article: Analysis of Shared Variants between Cancer Biospecimens
Analysis of Shared Variants between Cancer Biospecimens Open
Purpose: Mutational data from multiple solid and liquid biospecimens of a single patient are often integrated to track cancer evolution. However, there is no accepted framework to resolve if individual samples from the same individual shar…
View article: Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors
Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors Open
PURPOSE The molecular drivers underlying mucinous tumor pathogenicity are poorly understood. GNAS mutations predict metastatic burden and treatment resistance in mucinous appendiceal adenocarcinoma. We investigated the pan-cancer clinicopa…
View article: Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses
Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses Open
Increasing evidence implicates the tumor microbiota as a factor that can influence cancer progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics targeting anaerobic bacteria substantially improved di…
View article: Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer
Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer Open
Patients with POLE/D1pd mCRC showed more favorable outcomes compared to dMMR/MSI-H mCRC to treatment with ICIs in terms of tumor response and survival.
View article: Light and temperature regulate m<sup>6</sup>A-RNA modification to regulate growth in plants
Light and temperature regulate m<sup>6</sup>A-RNA modification to regulate growth in plants Open
N6-methyladenosine is a highly dynamic, abundant mRNA modification which is an excellent potential mechanism for fine tuning gene expression. Plants adapt to their surrounding light and temperature environment using complex gene regulatory…
View article: UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue-light receptor to regulate growth
UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue-light receptor to regulate growth Open
All organisms undergo growth, which is precisely controlled by exogenous and endogenous signals. Unchecked growth often leads to neoplasia and other developmental defects, severely affecting an organism’s fitness. Light is a vital exogenou…
View article: Rapid expression of COVID-19 proteins by transient expression in tobacco
Rapid expression of COVID-19 proteins by transient expression in tobacco Open
In 2020 we suffered from a major global pandemic caused by the SARS-CoV-2 coronavirus. Efforts to contain the virus include the development of rapid tests and vaccines, which require a ready supply of viral proteins. Here we report the pro…
View article: Characterization of <i>spa</i> mutants in the moss <i>Physcomitrella</i> provides evidence for functional divergence of <i><scp>SPA</scp></i> genes during the evolution of land plants
Characterization of <i>spa</i> mutants in the moss <i>Physcomitrella</i> provides evidence for functional divergence of <i><span>SPA</span></i> genes during the evolution of land plants Open
Summary The Arabidopsis COP 1/ SPA complex is a key repressor of photomorphogenesis that suppresses light signaling in the dark. Both COP 1 and SPA proteins are essential components of this complex. Although COP 1 also exists in humans, SP…
View article: Mutations in the N‐terminal kinase‐like domain of the repressor of photomorphogenesis <scp>SPA</scp>1 severely impair <scp>SPA</scp>1 function but not light responsiveness in Arabidopsis
Mutations in the N‐terminal kinase‐like domain of the repressor of photomorphogenesis <span>SPA</span>1 severely impair <span>SPA</span>1 function but not light responsiveness in Arabidopsis Open
Summary The COP 1/ SPA complex is an E3 ubiquitin ligase that acts as a key repressor of photomorphogenesis in dark‐grown plants. While both COP 1 and the four SPA proteins contain coiled‐coil and WD ‐repeat domains, SPA proteins differ fr…
View article: Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function
Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function Open
Diaphanous-related formins are eukaryotic actin nucleation factors regulated by an autoinhibitory interaction between the N-terminal RhoGTPase-binding domain (mDiaN) and the C-terminal Diaphanous-autoregulatory domain (DAD). Although the a…