Daniel Roche
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View article: Case Report: Metabolic, inflammatory, and neurological improvements after a ketogenic diet in a woman with treatment-resistant schizophrenia and metabolic syndrome
Case Report: Metabolic, inflammatory, and neurological improvements after a ketogenic diet in a woman with treatment-resistant schizophrenia and metabolic syndrome Open
We report the case of a 48-year-old woman with treatment-resistant schizophrenia (TRS) and metabolic syndrome who completed a 5-week medical ketogenic diet (KD) in an inpatient setting. The patient was initially started on a 2.5:1 ratio of…
View article: T cells are associated with negative symptoms in persons with anti-gliadin antibody positive schizophrenia and related disorders
T cells are associated with negative symptoms in persons with anti-gliadin antibody positive schizophrenia and related disorders Open
These hypothesis-generating findings suggest T cell dysfunction in AGA+ SRD, suggesting Tregs mitigating negative symptom severity, but also an unidentified other T cell population possibly contributing to negative symptomatology.
View article: Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomics
Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomics Open
Alcohol use disorder (AUD) is a complex condition with diverse molecular underpinnings. Chronic alcohol exposure is associated with alterations in both innate and adaptive immune cell populations that in turn contribute to AUD susceptibili…
View article: Under What Circumstances Do Pregnant Women Use Cannabis and Alcohol? The Contributions of Risk Perception, Mental Health, and Individual Context
Under What Circumstances Do Pregnant Women Use Cannabis and Alcohol? The Contributions of Risk Perception, Mental Health, and Individual Context Open
Background: Alcohol and cannabis use during pregnancy are prevalent health concerns in the United States due to potentially hazardous effects to both mother and fetus, however pregnant women still use both substances at high rates. Perceiv…
View article: Machine learning model development to retrospectively predict suicide attempts in the Millenium Cohort Study sample
Machine learning model development to retrospectively predict suicide attempts in the Millenium Cohort Study sample Open
Introduction Suicidal behavior is a complex phenomenon that affects all demographics, with children and adolescents being particularly vulnerable. It is associated with multifactorial conditions that must be considered for the development …
View article: Pan T cells, Helper T cells, and Regulatory T cells are Associated with Negative Symptoms in Persons with Anti-Gliadin Antibody Positive Schizophrenia and Related Disorders
Pan T cells, Helper T cells, and Regulatory T cells are Associated with Negative Symptoms in Persons with Anti-Gliadin Antibody Positive Schizophrenia and Related Disorders Open
Background About one in three persons with a schizophrenia related disorder (SRD) have elevated anti-gliadin IgG antibodies (AGA). This AGA positive (AGA+) subgroup of SRD clinically has a higher burden of negative symptoms and are symptom…
View article: Randomized Double Blind Inpatient Study of a Gluten-Free Diet in Persons with Schizophrenia
Randomized Double Blind Inpatient Study of a Gluten-Free Diet in Persons with Schizophrenia Open
Summary Background Schizophrenia and related disorders (SRD) are characterized by positive and negative symptoms, such as anhedonia and avolition. There are no current FDA approved treatments for negative symptoms, which is a critical gap …
View article: Index
Index Open
a toxic environment, 368,
View article: Associations among Trauma Exposure, Post-Traumatic Stress Symptoms and Alcohol Use in Black/African American Treatment-Seeking Adults
Associations among Trauma Exposure, Post-Traumatic Stress Symptoms and Alcohol Use in Black/African American Treatment-Seeking Adults Open
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD; ClinicalTrials.gov Identifier: NCT02884908.
View article: 223 Anti-TnMuc1 CAR-T cells that are conditionally armed with IL12 eliminate adenocarcinomas in preclinical models
223 Anti-TnMuc1 CAR-T cells that are conditionally armed with IL12 eliminate adenocarcinomas in preclinical models Open
Background Chimeric antigen receptor T (CAR-T) cell therapeutics have been successful at driving remissions in several B cell malignancies, but their efficacy against most tumor types remains limited. An emerging strategy to increase CAR-T…
View article: The Effects of Menstrual Cycle Hormones on Responses to Varenicline and Naltrexone Among Female Heavy Drinking Smokers
The Effects of Menstrual Cycle Hormones on Responses to Varenicline and Naltrexone Among Female Heavy Drinking Smokers Open
Aims Women often experience poorer smoking cessation outcomes in comparison to men. Menstrual cycle phase and sex hormones may influence smoking behavior and alter response to opioid antagonist medications. Less is known about the effects …
View article: A Scoping Review of Gender, Sex and Sexuality Differences in Polysubstance Use in Adolescents and Adults
A Scoping Review of Gender, Sex and Sexuality Differences in Polysubstance Use in Adolescents and Adults Open
Background Polysubstance use is a common, problematic behavior that increases risk of harm to self and others. Research suggests that rates may vary based on gender, sex and sexuality. Understanding the current state of this literature may…
View article: A Narrative Literature Review of the Epidemiology, Etiology, and Treatment of Co-Occurring Panic Disorder and Opioid Use Disorder
A Narrative Literature Review of the Epidemiology, Etiology, and Treatment of Co-Occurring Panic Disorder and Opioid Use Disorder Open
Based on findings in the field, we provide recommendations for future research as well as treatment considerations for co-occurring panic and opioid use disorders.
View article: SIGH, what’s in a name? An examination of the factor structure and criterion validity of the (Structured Interview Guide for the) Hamilton Anxiety scale (SIGH-A) in a sample of African American adults with co-occurring trauma experience and heavy alcohol use.
SIGH, what’s in a name? An examination of the factor structure and criterion validity of the (Structured Interview Guide for the) Hamilton Anxiety scale (SIGH-A) in a sample of African American adults with co-occurring trauma experience and heavy alcohol use. Open
The Hamilton Anxiety Inventory (HAM-A) is one of the oldest and most commonly used anxiety rating scales in clinical research. Despite its ubiquity, no studies have examined the scale's underlying factor structure and criterion validity am…
View article: A meta‐regression of methodological features that predict the effects of medications on the subjective response to alcohol
A meta‐regression of methodological features that predict the effects of medications on the subjective response to alcohol Open
Background Alcohol administration paradigms have been used for early efficacy testing of novel compounds for alcohol use disorder (AUD). There has been an ongoing debate about sample characteristics and methodological features that affect …
View article: Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta‐analysis
Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta‐analysis Open
Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve attenuation of the hedonic effects of alcohol and poten…
View article: Lack of Association between Opioid-Receptor Genotypes and Smoking Cessation Outcomes in a Randomized, Controlled Naltrexone Trial
Lack of Association between Opioid-Receptor Genotypes and Smoking Cessation Outcomes in a Randomized, Controlled Naltrexone Trial Open
Aims The present study examined how variation in mu- (OPRM1), kappa- (OPRK), and delta- (OPRD) opioid receptor genes may influence the efficacy of naltrexone in the context of a smoking cessation trial. Methods The study’s primary objectiv…