O. M. Lesnyak
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View article: The effect of smoking cessation on rheumatoid arthritis activity, pain intensity, and quality of life in patients
The effect of smoking cessation on rheumatoid arthritis activity, pain intensity, and quality of life in patients Open
Smoking is one of the main proven environmental factors that worsen the course and effectiveness of rheumatoid arthritis (RA) treatment. The aim – to evaluate the effect of smoking cessation on rheumatoid arthritis activity, pain, and qual…
View article: Mast Cell Association with the Microenvironment of a Phosphaturic Mesenchymal Tumour Secreting Fibroblast Growth Factor 23
Mast Cell Association with the Microenvironment of a Phosphaturic Mesenchymal Tumour Secreting Fibroblast Growth Factor 23 Open
Background: Phosphaturic mesenchymal tumours secreting fibroblast growth factor 23 (hereinafter referred to as FGF23+ PMT) are rare neoplasms that can cause hypophosphataemic osteomalacia, owing to excessive FGF23 production. Mast cells (M…
View article: Interdisciplinary consensus on the care of elderly patients with hip fractures based on an orthogeriatric approach
Interdisciplinary consensus on the care of elderly patients with hip fractures based on an orthogeriatric approach Open
This consensus was prepared by a group of experts from various specialties in the interests of improving the quality of specialized medical care for elderly and senile patients with hip fractures, which are almost always the result of oste…
View article: Efficacy of a smoking cessation program in patients with rheumatoid arthritis
Efficacy of a smoking cessation program in patients with rheumatoid arthritis Open
Background. Smoking is a significant risk factor for the development of chronic non-infectious diseases such as malignant tumors, cardiovascular and respiratory diseases. Smoking is also considered one of the most important external risk f…
View article: Interdisciplinary consensus on the care of elderly patients with hip fractures based on an orthogeriatric approach
Interdisciplinary consensus on the care of elderly patients with hip fractures based on an orthogeriatric approach Open
This consensus was prepared by a group of experts from various specialties in the interests of improving the quality of specialized medical care for elderly and old age patients with hip fractures, which are almost always the result of ost…
View article: Interdisciplinary Consensus on the Care of Elderly Patients with Hip Fractures Through an Orthogeriatric Approach
Interdisciplinary Consensus on the Care of Elderly Patients with Hip Fractures Through an Orthogeriatric Approach Open
INTRODUCTION. The development of an interdisciplinary consensus on the care of elderly and elderly patients with proximal femoral fractures is an urgent problem of modern medicine. The provisions of this Consensus will help to establish ef…
View article: Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from ADRB2 Gene Polymorphism
Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from ADRB2 Gene Polymorphism Open
Osteoporosis is characterized by increased resorption and decreased bone formation; it is predominantly influenced by genetic factors. G-protein coupled receptors (GPCRs) play a vital role in bone homeostasis, and mutations in these genes …
View article: SNPs in GPCR Genes and Impaired Osteogenic Potency in Osteoporotic Patient Lines-Based Study
SNPs in GPCR Genes and Impaired Osteogenic Potency in Osteoporotic Patient Lines-Based Study Open
G-protein-coupled receptors (GPCRs) have emerged as critical regulators of bone development and remodeling. In this study, we aimed to identify specific GPCR mutations in osteoporotic patients via next-generation sequencing (NGS). We perfo…
View article: Skeletal abnormalities, pediatric-onset severe osteoporosis, and multiple fragility fractures in a patient with a novel CTNNB1 de novo variant
Skeletal abnormalities, pediatric-onset severe osteoporosis, and multiple fragility fractures in a patient with a novel CTNNB1 de novo variant Open
We report a case of a patient with a de novo germline heterozygous truncating variant of CTNNB1 gene (c.2172del, p.Tyr724Ter) causing neurodevelopmental disorder with spastic diplegia and visual defects syndrome (NEDSDV) asso…
View article: The consensus of experts of the russian association for osteoporosis on the long-term treatment of osteoporosis with bisphosphonates
The consensus of experts of the russian association for osteoporosis on the long-term treatment of osteoporosis with bisphosphonates Open
Bisphosphonates are the most commonly used drugs for the treatment of osteoporosis and reducing the risk of fractures, which were introduced into clinical practice more than 30 years ago. The bisphosphonate group includes oral (alendronic …
View article: Long-term treatment with bisphosphonates in clinical practice: advantages, main problems and risks
Long-term treatment with bisphosphonates in clinical practice: advantages, main problems and risks Open
Bisphosphonates are the main class of drugs for treatment osteoporosis (OP) and other diseases with increased bone resorption, as bisphosphonates are very effective in reducing risk of fracture. The problem of maintaining the effectiveness…
View article: Skeletal Abnormalities, Pediatric-Onset Severe Osteoporosis, and Multiple Fragility Fractures in a Patient with a De Novo Ctnnb1 Novel Variant
Skeletal Abnormalities, Pediatric-Onset Severe Osteoporosis, and Multiple Fragility Fractures in a Patient with a De Novo Ctnnb1 Novel Variant Open
View article: Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases
Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases Open
Introduction: Tumor-induced osteomalacia is an acquired rare disease manifested by hypophosphatemic osteomalacia due to excessive secretion of fibroblast growth factor 23 (FGF23). FGF 23 is a non-classical hormone secreted by bone tissue (…
View article: THU462 Clinical Features & Management Of FGF23 Secreting Tumors: Series Of 40 Clinical Cases
THU462 Clinical Features & Management Of FGF23 Secreting Tumors: Series Of 40 Clinical Cases Open
Disclosure: S. Gronskaia: None. Z. Belaya: None. L. Rozhinskaya: None. T. Dubovitskaya: None. E. Mamedova: None. E.A. Pigarova: None. M. Degtyarev: None. S. Rodionova: None. Y. Buklemishev: None. D. Babaeva: None. V. Vladimirova: None. N. …
View article: Experience of distance learning of a multidisciplinary approach in the management of an elderly patient with a low-energy fracture
Experience of distance learning of a multidisciplinary approach in the management of an elderly patient with a low-energy fracture Open
BACKGROUND: In the Russian Federation, high mortality and unsatisfactory treatment results of elderly and senile patients with low-energy fractures have been noted. Urgent implementation of a systematic approach to the treatment and preven…
View article: FRAX-based intervention thresholds for men in the Russian Federation: Expert consensus of the Russian association on osteoporosis
FRAX-based intervention thresholds for men in the Russian Federation: Expert consensus of the Russian association on osteoporosis Open
According to the European guidelines for osteoporosis, the same FRAX intervention threshold is suggested for men as for women. At the same time, in the Russian Federation, according to research data, an extremely low proportion of identifi…
View article: Comments on the use of Key Performance Indicators in evaluating the Organization of Fracture Liaison Services
Comments on the use of Key Performance Indicators in evaluating the Organization of Fracture Liaison Services Open
In recent years Fracture Liaison Services (FLS) have been established worldwide to reduce the number of fractures due to osteoporosis. Within the framework of the global campaign «Capture the fracture» by International Osteoporosis Foundat…
View article: An experience- and preference-based EQ-5D-3L value set derived using 18 months of longitudinal data in patients who sustained a fracture: results from the ICUROS
An experience- and preference-based EQ-5D-3L value set derived using 18 months of longitudinal data in patients who sustained a fracture: results from the ICUROS Open
Introduction EQ-5D-3L preference-based value sets are predominately based on hypothetical health states and derived in cross-sectional settings. Therefore, we derived an experience-based value set from a prospective observational study. Me…
View article: Role of G protein-associated membrane receptors in the pathogenesis of osteoporosis
Role of G protein-associated membrane receptors in the pathogenesis of osteoporosis Open
Osteoporosis is a chronic disease characterized by a pathological change in bone tissue, excessive fragility and a decrease in bone strength as a result of the predominance of bone resorption processes over the process of bone formation. T…
View article: The role and place of the FRAX calculator in initiation osteoporosis treatment: an analysis of the osteoporosis center registry
The role and place of the FRAX calculator in initiation osteoporosis treatment: an analysis of the osteoporosis center registry Open
Background: The growing frequency of fractures associated with osteoporosis, the significant costs of their treatment, disability and increased mortality make it an important and urgent task to optimize the diagnosis and treatment of osteo…
View article: Efforts of the Russian Association on Osteoporosis in 2021
Efforts of the Russian Association on Osteoporosis in 2021 Open
The Russian Association on Osteoporosis was established in 1995 and by now it has regional branches in 53 cities of the Russian Federation with total 116 members. The Association also includes the Society of Patients OSTEORUS (Chairman —…
View article: The effectiveness of screening to identify patients with osteoporosis/high risk of fractures in primary health care
The effectiveness of screening to identify patients with osteoporosis/high risk of fractures in primary health care Open
Background. The organization of screening for osteoporosis is an actual problem due to the need for early detection of patients with high risk of fractures and initiation of their treatment. Aim. The aim of our study was to study the effec…
View article: Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis
Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis Open
Due to continuous aging of population and increase in the number of elderly people, osteoporosis became socially significant disease leading to disability, increasing mortality and thereby putting an additional burden on the public healthc…
View article: Falls in older and senile patients. Clinical giudelines
Falls in older and senile patients. Clinical giudelines Open
Falls in old and senile age is one of the main geriatric syndromes that determine the prognosis of a patient's life and autonomy, regardless of the consequences. According to experts, 33% of people 65 years of age and older have a history …
View article: First results of the register of patients with osteoporosis included in the secondary fracture prevention services
First results of the register of patients with osteoporosis included in the secondary fracture prevention services Open
Background . To reduce the number of osteoporotic fractures in the world in recent years, — Fracture Liaison Service has been created. Since 2019, the development of a register of patients included in the Secondary Fracture Prevention name…
View article: Problems in patient management and the impact of osteoporosis therapy on the incidence of clinical infection
Problems in patient management and the impact of osteoporosis therapy on the incidence of clinical infection Open
The global diversion of health resources during the COVID-19 pandemic from the provision of routine medical care, and the more frequent and severe course of this infection in older patients justify the need to study the impact of the pande…
View article: Burden of Osteoporosis in the Countries of the Eurasian Region
Burden of Osteoporosis in the Countries of the Eurasian Region Open
The public health burden of osteoporosis estimated by the results of clinical and population-based researches in most of the former USSR is uncertain for today. The objective of this audit (Audit-2020) was the epidemiological, medico-socia…
View article: FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan
FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan Open
For the 8 Eurasian countries, the newly established FRAX-based intervention thresholds provide an opportunity to improve the clinical detection of both men and women with a high risk of fracture and improve treatment rates.
View article: Vitamin D status in Armenian women: a stratified cross-sectional cluster analysis
Vitamin D status in Armenian women: a stratified cross-sectional cluster analysis Open
View article: Clinical and instrumental associations of knee osteoarthrosis and pathology of the veins of the lower extremities
Clinical and instrumental associations of knee osteoarthrosis and pathology of the veins of the lower extremities Open
Knee osteoarthritis (OA) and varicose disease of the lower extremities (VD) are two diseases common in middle– aged and older women. Questions about whether their combination is accidental or natural and whether VD affects the course and s…