Ove B. Schaffalitzky de Muckadell
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View article: General practice variation in peptic ulcer prophylaxis: a nationwide register-based study
General practice variation in peptic ulcer prophylaxis: a nationwide register-based study Open
A significant under-prescribing of ulcer prophylaxis is common across all general practice characteristics, and only few associations with practice characteristics were present. Most efforts to rationalize PPI prescribing have aimed at red…
View article: Endoscopic treatment options in peptic ulcer bleeding
Endoscopic treatment options in peptic ulcer bleeding Open
This review evaluates the evidence for the use of over-the-scope clips (OTSC), topical haemostatic agents (THA), and prophylactic embolisation (PE) in patients with peptic ulcer bleeding (PUB). The use of OTSC and THA may have the potentia…
View article: The Effect of Non-pooled Multidonor Faecal Microbiota Transplantation for Inducing Clinical Remission in Patients with Chronic Pouchitis: Results from a Multicentre, Randomised, Double-blinded, Placebo-controlled Trial [MicroPouch]
The Effect of Non-pooled Multidonor Faecal Microbiota Transplantation for Inducing Clinical Remission in Patients with Chronic Pouchitis: Results from a Multicentre, Randomised, Double-blinded, Placebo-controlled Trial [MicroPouch] Open
Background and Aims To investigate if treatment with non-pooled, multidonor faecal microbiota transplantation [FMT] for 4 weeks was superior to placebo to induce clinical remission in patients with chronic pouchitis. Methods The study was …
View article: Critical reading of articles on randomised clinical trials
Critical reading of articles on randomised clinical trials Open
The randomised clinical trial is the most reliable study design to compare the effects of different interventions, however, the methodological quality of randomised clinical trials varies. In this review, the central considerations for cri…
View article: Doppler-Guided Second-Look Endoscopy in Peptic Ulcer Bleeding: A Randomised Controlled Trial
Doppler-Guided Second-Look Endoscopy in Peptic Ulcer Bleeding: A Randomised Controlled Trial Open
Background: Endoscopic treatment guided by Doppler endoscopic probes (DEPs) during index endoscopy may be associated with improved outcome in patients with peptic ulcer bleeding (PUB). As competencies for DEP evaluation are not always avai…
View article: Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients
Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients Open
Rebleeding is a frequent complication of peptic ulcer bleeding (PUB). The associated prognosis remains rather unclear because previous studies generally also included non-ulcer lesions. We aimed to identify predictors for rebleeding; clari…
View article: von Hippel-Lindau disease: Updated guideline for diagnosis and surveillance
von Hippel-Lindau disease: Updated guideline for diagnosis and surveillance Open
von Hippel Lindau disease (vHL) is caused by a hereditary predisposition to multiple neoplasms, especially hemangioblastomas in the retina and CNS, renal cell carcinomas (RCC), pheochromocytomas, neuroendocrine pancreatic tumours (PNET) an…
View article: Whole genome sequencing identifies rare genetic variants in familial pancreatic cancer patients
Whole genome sequencing identifies rare genetic variants in familial pancreatic cancer patients Open
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies with very high mortality and short survival time. About 5–10% of the PDAC patients have a familial predisposition to the disease designated as familial …
View article: Whole genome sequencing identifies rare germline variants enriched in cancer related genes in first degree relatives of familial pancreatic cancer patients
Whole genome sequencing identifies rare germline variants enriched in cancer related genes in first degree relatives of familial pancreatic cancer patients Open
First‐degree relatives (FDRs) of familial pancreatic cancer (FPC) patients have increased risk of developing pancreatic ductal adenocarcinoma (PDAC). Investigating and understanding the genetic basis for PDAC susceptibility in FPC predispo…
View article: Hypotension develops one to two hours before other symptoms in peptic ulcer rebleeding; a matched cohort study
Hypotension develops one to two hours before other symptoms in peptic ulcer rebleeding; a matched cohort study Open
Rebleeding is a frequent complication of peptic ulcer bleeding (PUB) and is associated with increased mortality. Blood pressure and heart rate are two easy non-invasive measurements to evaluate the hemodynamics and therefore a standard obs…
View article: Cohort profile and heritability assessment of familial pancreatic cancer: a nation-wide study
Cohort profile and heritability assessment of familial pancreatic cancer: a nation-wide study Open
Familial Pancreatic Cancer (FPC) is responsible for up to 10% of all cases of pancreatic ductal adenocarcinoma (PDAC). Individuals predisposed for FPC have an estimated lifetime risk of 16–39% of developing PDAC. While heritability of PDAC…
View article: Analysis of patterns of bacteremia and 30-day mortality in patients with acute cholangitis over a 25-year period
Analysis of patterns of bacteremia and 30-day mortality in patients with acute cholangitis over a 25-year period Open
Our results indicate that presence of bacteremia was associated with a nearly fourfold increase in 30-day mortality among AC patients.
View article: When does proton pump inhibitor treatment become long term? A scoping review
When does proton pump inhibitor treatment become long term? A scoping review Open
Objective Proton pump inhibitor (PPI) use has risen substantially, primarily driven by ongoing use over months to years. However, there is no consensus on how to define long-term PPI use. Our objectives were to review and compare definitio…
View article: Heritability of familial pancreatic cancer in a Danish national family cohort
Heritability of familial pancreatic cancer in a Danish national family cohort Open
Background: Familial Pancreatic Cancer (FPC) is responsible for up to 10% of all cases of pancreatic ductal adenocarcinoma (PDAC). Individuals predisposed for FPC have an estimated lifetime risk of 18-38% of developing PDAC. While heritabi…
View article: Cohort profile and heritability assessment of familial pancreatic cancer: a nation-wide study
Cohort profile and heritability assessment of familial pancreatic cancer: a nation-wide study Open
Familial Pancreatic Cancer (FPC) is responsible for up to 10% of all cases of pancreatic ductal adenocarcinoma (PDAC). Individuals predisposed for FPC have an estimated lifetime risk of 16–39% of developing PDAC. While heritability of PDAC…
View article: A positive diagnostic strategy is safe and saves endoscopies in patients with irritable bowel syndrome: A five‐year follow‐up of a randomized controlled trial
A positive diagnostic strategy is safe and saves endoscopies in patients with irritable bowel syndrome: A five‐year follow‐up of a randomized controlled trial Open
Background Previously, the diagnosis of irritable bowel syndrome (IBS) required exclusion of organic causes by extensive diagnostic testing. Newer guidelines recommend IBS as a positive diagnosis based on symptoms with limited testing. We …
View article: <b>Ueg</b>Week 2020 Poster Presentations
<b>Ueg</b>Week 2020 Poster Presentations Open
United European Gastroenterology JournalVolume 8, Issue S8 p. 144-887 UEG Week 2020 Poster PresentationsOpen Access Ueg Week 2020 Poster Presentations First published: 01 October 2020 https://doi.org/10.1177/2050640620927345Citations: 2Abo…
View article: Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer
Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer Open
Purpose: High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grad…
View article: Validation of a Simple Quality‐of‐Life Score for Identification of Minimal and Prediction of Overt Hepatic Encephalopathy
Validation of a Simple Quality‐of‐Life Score for Identification of Minimal and Prediction of Overt Hepatic Encephalopathy Open
Minimal hepatic encephalopathy (MHE) is underdiagnosed because most clinics refrain from psychometric testing. Diagnostic activities need to go up so patients with MHE can get the treatment their condition requires. The sickness impact pro…
View article: Mixed connective tissue disease
Mixed connective tissue disease Open
Mixed connective tissue disease (MCTD) is a rare connective tissue disorder combining clinical features of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM) (see these terms) and/or rheumatoid arthritis (RA).
View article: Prediction of overt hepatic encephalopathy by the continuous reaction time method and the portosystemic encephalopathy syndrome test in clinically mentally unimpaired patients with cirrhosis
Prediction of overt hepatic encephalopathy by the continuous reaction time method and the portosystemic encephalopathy syndrome test in clinically mentally unimpaired patients with cirrhosis Open
The CRT test was clinically useful in identifying two-thirds of clinically mentally unimpaired cirrhosis patients who later experienced OHE, and the use of both the CRT and PSE showed satisfactory prediction by identifying three-fourths of…
View article: A model to predict the risk of aspirin/non‐steroidal anti‐inflammatory drugs‐related upper gastrointestinal bleeding for the individual patient
A model to predict the risk of aspirin/non‐steroidal anti‐inflammatory drugs‐related upper gastrointestinal bleeding for the individual patient Open
Upper gastrointestinal bleeding is a feared complication of using non‐steroidal anti‐inflammatory drugs (NSAIDs) or aspirin. Studies predicting the incidence rate for individuals with a given set of characteristics are lacking. The aim of …
View article: Prescribing of proton-pump inhibitors: auditing the management and reasons for prescribing in Danish general practice
Prescribing of proton-pump inhibitors: auditing the management and reasons for prescribing in Danish general practice Open
Background Prescribing of proton-pump inhibitors has substantially increased. Information from clinical settings is warranted to gain insight into reasons for prescribing. Aim To investigate Danish General Practitioners’ management and rea…
View article: Editorial: population‐based testing for <i>Helicobacter pylori</i> in Western countries. Authors' reply
Editorial: population‐based testing for <i>Helicobacter pylori</i> in Western countries. Authors' reply Open
Linked Content This article is linked to Høgh et al and Vakil papers. To view these articles, visit https://doi.org/10.1111/apt.15193 and https://doi.org/10.1111/apt.15224 .
View article: The cost effectiveness of <i>Helicobacter pylori</i> population screening—economic evaluation alongside a randomised controlled trial with 13‐year follow‐up
The cost effectiveness of <i>Helicobacter pylori</i> population screening—economic evaluation alongside a randomised controlled trial with 13‐year follow‐up Open
Summary Background Helicobacter pylori eradication improves dyspeptic symptoms in 8%‐10%, prevents peptic ulcer and may reduce the risk of gastric cancer. Availability of a high quality diagnostic test and an effective treatment makes popu…
View article: Unchanged mortality in patients with acute cholangitis despite an increase in malignant etiologies – a 25-year epidemiological study
Unchanged mortality in patients with acute cholangitis despite an increase in malignant etiologies – a 25-year epidemiological study Open
Background and aims: Acute cholangitis (AC) is a rare but serious condition, with an incidence of 7.0 per 10,000 people and mortality rates up to 10%. The aim of this study was to describe changes in obstruction etiology, comorbidities, cl…
View article: Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion
Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion Open
Losartan 4 mg/kg/day did not increase renal sodium excretion in this model of liver cirrhosis, although the urinary ANGII excretion was increased. The BDL animals tolerated Losartan poorly, and the treatment induced a 150 times higher PRC.