Paul Thelen
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View article: Modulating the Heat Sensitivity of Prostate Cancer Cell Lines In Vitro: A New Impact for Focal Therapies
Modulating the Heat Sensitivity of Prostate Cancer Cell Lines In Vitro: A New Impact for Focal Therapies Open
Focal therapies such as high-intensity focused ultrasound (HiFU) are an emerging therapeutic option for prostate cancer (PCA). Thermal or mechanical effects mediate most therapies. Moreover, locally administered drugs such as bicalutamide …
View article: Enhancing PSMA-uptake with androgen deprivation therapy – a new way to detect prostate cancer metastases?
Enhancing PSMA-uptake with androgen deprivation therapy – a new way to detect prostate cancer metastases? Open
Our preliminary results of this feasibility assessment indicate a possible enhancing effect of PSMA-imaging induced by low-dose ADT. Despite several limitations and the small number of patients, this could be a new approach to improve stag…
View article: Testosterone metabolites inhibit proliferation of castration- and therapy-resistant prostate cancer
Testosterone metabolites inhibit proliferation of castration- and therapy-resistant prostate cancer Open
Novel treatments for castration-resistant prostate cancer (CRPC) such as abiraterone acetate (AA) or enzalutamide effectively target the androgen pathway to arrest aberrant signalling and cell proliferation. Testosterone is able to inhibit…
View article: Prospects of estrogen receptor β activation in the treatment of castration-resistant prostate cancer
Prospects of estrogen receptor β activation in the treatment of castration-resistant prostate cancer Open
Advanced prostate cancer can develop into castration-resistant prostate cancer (CRPC). This process is mediated either by intratumoral ligand synthesis or by mutations or aberrations of the androgen receptor (AR) or its cofactors. To date,…