Ulrich Wenzel
YOU?
Author Swipe
View article: Alternative Splicing in Mechanically Stretched Podocytes as a Model of Glomerular Hypertension
Alternative Splicing in Mechanically Stretched Podocytes as a Model of Glomerular Hypertension Open
Key Points Mechanical stretch induced over 3000 alternative splicing events in podocytes, affecting gene expression and protein abundance. Seventeen genes showed consistent splicing events across multiple analysis tools, with key isoform c…
View article: Aortic aneurysm and dissection: complement and precision medicine in aortic disease
Aortic aneurysm and dissection: complement and precision medicine in aortic disease Open
Aortic disease encompasses life-threatening conditions such as aortic aneurysm and dissection, which are associated with high prevalence, morbidity, and mortality. The complement system, a key component of innate immunity, not only defends…
View article: Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease
Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease Open
Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney disease with the worst prognosis. Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis, anti-glomerular basement membrane (anti-GB…
View article: Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis Open
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN r…
View article: Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension
Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension Open
Background Alterations in pre-mRNA splicing play an important role in disease pathophysiology. However, the role of alternative splicing (AS) for podocytes in hypertensive nephropathy (HN) has not been investigated. The purpose of the Sys_…
View article: Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis Open
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (ANCA-GN). To date, treatment of most patients with ANCA…
View article: Increased blood pressure after nonsevere COVID-19
Increased blood pressure after nonsevere COVID-19 Open
Background: Various sequelae have been described after nonsevere coronavirus disease 2019 (COVID-19), but knowledge on postacute effects on blood pressure is limited. Methods: This is a cross-sectional analysis of blood pressure profiles i…
View article: Complement component C3 as a new target to lower albuminuria in hypertensive kidney disease
Complement component C3 as a new target to lower albuminuria in hypertensive kidney disease Open
Background and Purpose Complement activation may drive hypertension through its effects on immunity and tissue integrity. Experimental Approach We examined expression of C3, the central protein of the complement cascade, in hypertension. K…
View article: No compliment for complement: Kidney biopsies of patients with malignant nephrosclerosis show no complement activation
No compliment for complement: Kidney biopsies of patients with malignant nephrosclerosis show no complement activation Open
The complement system represents an ancient part of innate immunity and is comprised of multiple serum proteins. In several pathological conditions, including atypical hemolytic syndrome (aHUS), complement activation is contributing to dis…
View article: Deficiency of complement C3a and C5a receptors does not prevent angiotensin II–induced hypertension and hypertensive end-organ damage
Deficiency of complement C3a and C5a receptors does not prevent angiotensin II–induced hypertension and hypertensive end-organ damage Open
Complement activation may drive the pathology of hypertension through its effects on innate and adaptive immune responses, aside from direct effects on tissue integrity. Recently it was suggested that hypertension is a disease characterize…
View article: Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury
Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury Open
Glucocorticoids remain a cornerstone of therapeutic regimes for autoimmune and chronic inflammatory diseases - for example, in different forms of crescentic glomerulonephritis - because of their rapid antiinflammatory effects, low cost, an…
View article: GM-CSF drives immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
GM-CSF drives immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12 Open
Glomerulonephritis is a group of immune-mediated diseases that cause inflammation within the glomerulus and adjacent compartments of the kidney and is a major cause of end-stage renal disease. T cells are among the main drivers of glomerul…
View article: Emerging fields for therapeutic targeting of the aldosterone–mineralocorticoid receptor signaling pathway
Emerging fields for therapeutic targeting of the aldosterone–mineralocorticoid receptor signaling pathway Open
International audience
View article: Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage
Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage Open
Introduction: Chronic activation of the mineralocorticoid receptor (MR) leads to pathological processes like inflammation and fibrosis during cardiorenal disease. Modulation of immunological processes in the heart or kidney may serve as a …
View article: The role of the mineralocorticoid receptor in immune cells in cardiovascular disease
The role of the mineralocorticoid receptor in immune cells in cardiovascular disease Open
Chronic low‐grade inflammation and immune cell activation are important mechanisms in the pathophysiology of cardiovascular disease (CVD). Therefore, targeted immunosuppression is a promising novel therapy to reduce cardiovascular risk. In…
View article: Canonical and non‐canonical functions of the complement system in health and disease
Canonical and non‐canonical functions of the complement system in health and disease Open
This article is part of a themed issue on Canonical and non-canonical functions of the complement system in health and disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issueto…
View article: Efficiency of Percutaneous Stent Angioplasty in Renal Artery Stenosis – 15 Years of Experience at a Single Center
Efficiency of Percutaneous Stent Angioplasty in Renal Artery Stenosis – 15 Years of Experience at a Single Center Open
Purpose To determine the therapeutic efficiency of percutaneous revascularization in renal artery stenosis (RAS), as well as the role of comprehensive factors such as patient selection and degree of artery stenosis, on clinical outcome. Me…
View article: The role of complement in arterial hypertension and hypertensive end organ damage
The role of complement in arterial hypertension and hypertensive end organ damage Open
Increasing evidence indicates that hypertension and hypertensive end organ damage are not only mediated by haemodynamic injury but that inflammation also plays an important role. The complement system protects the host from a hostile micro…
View article: The role of complement in arterial hypertension and hypertensive end organ damage
The role of complement in arterial hypertension and hypertensive end organ damage Open
Increasing evidence indicates that hypertension and hypertensive end organ damage are not only mediated by hemodynamic injury but that inflammation plays an important role in the pathophysiology and contributes to the deleterious consequen…