Oakley C. Olson
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View article: MON-704 Effects of Semaglutide on BMI and Cardiometabolic Profile in Adolescents with Variants in Monogenic Obesity-related Genes
MON-704 Effects of Semaglutide on BMI and Cardiometabolic Profile in Adolescents with Variants in Monogenic Obesity-related Genes Open
Disclosure: M. Salama: None. F. Pinto e Vairo: None. D. Hassan: None. S. Pittock: None. A. Lteif: None. O. Olson: None. A. Al Nofal: None. K. Leopold: None. S. Kumar: None. Objective: This study aimed to evaluate the effects of semaglutide…
View article: Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation
Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation Open
SUMMARY Hematopoietic stem and progenitor cells (HSPC) respond to infections, inflammation, and regenerative challenges using a collection of cellular and molecular mechanisms termed emergency myelopoiesis (EM) pathways. However, it remain…
View article: Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production Open
Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production and control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors to ste…
View article: Figs S8-S9 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S8-S9 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Cathepsin B loss impairs nerve invasion independent of tumor growth. Loss of this protease may keep the protective perineurium intact. This file contains two supplemental figures (S8 and S9).
View article: Fig S1 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Fig S1 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Nerve mediated inflammatory monocyte recruitment in perineural invasion.
View article: Figs S2-S5 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S2-S5 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
CCL2 and CCR2 loss results in impaired PNI and IM recruitment following cancer injection independent of tumor growth. This file contains 4 supplemental figures (S2-S5), which demonstrate the importance of both CCR2 and CCL2 in IM recruitme…
View article: Data from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Data from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells to enable PNI, but the contributing conditions within the tumor microenvironment …
View article: Fig S7 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Fig S7 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Anti-CCL2 treatment impairs IM recruitment and nerve invasion.
View article: Figs S10-S11 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S10-S11 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Analysis of human prostate cancer and adenoid cystic carcinoma specimens demonstrates macrophage infiltration around the majority of invaded nerves. This file contains two supplemental figures (S10-S11).
View article: Fig S1 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Fig S1 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Nerve mediated inflammatory monocyte recruitment in perineural invasion.
View article: Fig S6 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Fig S6 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
CCL3 ELISA performed on nerve lysates.
View article: Figs S2-S5 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S2-S5 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
CCL2 and CCR2 loss results in impaired PNI and IM recruitment following cancer injection independent of tumor growth. This file contains 4 supplemental figures (S2-S5), which demonstrate the importance of both CCR2 and CCL2 in IM recruitme…
View article: Supplemental Tables 1 and 2 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Supplemental Tables 1 and 2 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Tables contain information on the list of candidate genes screened from murine macrophages and clinical data on human pancreatic samples. This file contains 2 tables (Supplemental Tables 1 and 2).
View article: Fig S7 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Fig S7 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Anti-CCL2 treatment impairs IM recruitment and nerve invasion.
View article: Figs S12-S13 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S12-S13 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Clinical outcomes in human PDA as a function of macropahge infiltration and CTSB expression. This file contains two supplemental figures (S12-S13).
View article: Figs S8-S9 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S8-S9 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Cathepsin B loss impairs nerve invasion independent of tumor growth. Loss of this protease may keep the protective perineurium intact. This file contains two supplemental figures (S8 and S9).
View article: Figs S10-S11 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S10-S11 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Analysis of human prostate cancer and adenoid cystic carcinoma specimens demonstrates macrophage infiltration around the majority of invaded nerves. This file contains two supplemental figures (S10-S11).
View article: Supplemental Tables 1 and 2 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Supplemental Tables 1 and 2 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Tables contain information on the list of candidate genes screened from murine macrophages and clinical data on human pancreatic samples. This file contains 2 tables (Supplemental Tables 1 and 2).
View article: Figs S12-S13 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Figs S12-S13 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Clinical outcomes in human PDA as a function of macropahge infiltration and CTSB expression. This file contains two supplemental figures (S12-S13).
View article: Fig S6 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Fig S6 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
CCL3 ELISA performed on nerve lysates.
View article: Data from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Data from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression Open
Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells to enable PNI, but the contributing conditions within the tumor microenvironment …
View article: Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Antibody Details
View article: Data from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Data from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Tumor relapse after chemotherapy-induced regression is a major clinical problem, because it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are known to limit the cytotoxic effects of chemotherapy in precli…
View article: Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Effects of various cytotoxic agents on TAM accumulation in three mouse tumor models (S1); Further Characterization of MRC1+ TAMs in mouse tumors (S2); VEGFA lmmunofluorescence in control and CTX-treated LLC1 tumors (S3); Role of hypoxic (i…
View article: Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
View article: Data from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Data from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Tumor relapse after chemotherapy-induced regression is a major clinical problem, because it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are known to limit the cytotoxic effects of chemotherapy in precli…
View article: Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Antibody Details
View article: Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Effects of various cytotoxic agents on TAM accumulation in three mouse tumor models (S1); Further Characterization of MRC1+ TAMs in mouse tumors (S2); VEGFA lmmunofluorescence in control and CTX-treated LLC1 tumors (S3); Role of hypoxic (i…
View article: Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy Open
Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy