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View article: Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis
Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis Open
Cognitive manifestations, including impairment in language and executive functions, are seen in amyotrophic lateral sclerosis (ALS), but the mechanisms that underlie these deficits remain unclear. To address this, we mapped prefrontal cort…
View article: Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex
Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex Open
Summary Identifying senescent cells poses challenges due to their rarity, heterogeneity, and lack of a definitive marker. We performed Visium spatial transcriptomics (ST) and single nucleus RNA sequencing (snRNA-seq) on non-pathological hu…