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View article: Evaluation of plasma anti-CS3 and anti-LTB IgG avidity among Zambian children vaccinated with ETVAX
Evaluation of plasma anti-CS3 and anti-LTB IgG avidity among Zambian children vaccinated with ETVAX Open
Background: Enterotoxigenic Escherichia coli (ETEC) remains a major cause of diarrheal disease in low- and middle-income countries (LMICs). To curb ETEC related diarrhoea, several candidate vaccines are in development, with ETVAX® being th…
View article: Application of a Novel Proteomic Microarray Reveals High Exposure to Diarrhoeagenic Escherichia coli among Children in Zambia Participating in a Phase I Clinical Trial
Application of a Novel Proteomic Microarray Reveals High Exposure to Diarrhoeagenic Escherichia coli among Children in Zambia Participating in a Phase I Clinical Trial Open
Diarrhoeagenic E. coli (DEC) significantly contributes to the burden of diarrhoea among children. Currently, there is no approved vaccine against DEC, but several vaccines against the enterotoxigenic E. coli (ETEC) pathotype are in advance…
View article: Impact of introduction of TB LAM in the TB testing algorithm at Levy Mwanawasa University Teaching Hospital on case detection and notifications
Impact of introduction of TB LAM in the TB testing algorithm at Levy Mwanawasa University Teaching Hospital on case detection and notifications Open
Introduction
TB-LAM tests were introduced in the TB program in Zambia in 2019, to aid in diagnosis of TB. We carried out a study to determine the impact that TB lipoarabinomannan (LAM) test has had on case identification and notification …
View article: Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach
Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach Open
Background Rotavirus gastroenteritis remains a leading cause of morbidity and mortality despite the introduction of vaccines. Research shows there are several factors contributing to the reduced efficacy of rotavirus vaccines in low- and m…
View article: Prevalence of Diarrhoeagenic Escherichia coli among Children Aged between 0–36 Months in Peri-Urban Areas of Lusaka
Prevalence of Diarrhoeagenic Escherichia coli among Children Aged between 0–36 Months in Peri-Urban Areas of Lusaka Open
Diarrhoea is a major contributor to childhood morbidity and mortality in developing countries, with diarrhoeagenic Escherichia coli being among the top aetiological agents. We sought to investigate the burden and describe the diarrhoeageni…
View article: Safety, tolerability, and immunogenicity of an oral inactivated ETEC vaccine (ETVAX®) with dmLT adjuvant in healthy adults and children in Zambia: An age descending randomised, placebo-controlled trial
Safety, tolerability, and immunogenicity of an oral inactivated ETEC vaccine (ETVAX®) with dmLT adjuvant in healthy adults and children in Zambia: An age descending randomised, placebo-controlled trial Open
The trial is registered with the Pan African Clinical Trials Registry (PACTR Ref. 201905764389804) and a description of this clinical trial is available on: https://pactr.samrc.ac.za/Trial Design.
View article: Review of: "FLAML-Boosted XGBoost Model for Autism Diagnosis: A Comprehensive Performance Evaluation"
Review of: "FLAML-Boosted XGBoost Model for Autism Diagnosis: A Comprehensive Performance Evaluation" Open
View article: Maternal and Infant Histo-Blood Group Antigen (HBGA) Profiles and Their Influence on Oral Rotavirus Vaccine (RotarixTM) Immunogenicity among Infants in Zambia
Maternal and Infant Histo-Blood Group Antigen (HBGA) Profiles and Their Influence on Oral Rotavirus Vaccine (RotarixTM) Immunogenicity among Infants in Zambia Open
Live-attenuated, oral rotavirus vaccines have significantly reduced rotavirus-associated diarrhoea morbidity and infant mortality. However, vaccine immunogenicity is diminished in low-income countries. We investigated whether maternal and …
View article: Maternal and Infant Histo-Blood Group Antigens (Hbga) Profiles and It’s Influence on Oral Rotavirus Vaccine (Rotarix®) Immunogenicity Among Infants in Zambia
Maternal and Infant Histo-Blood Group Antigens (Hbga) Profiles and It’s Influence on Oral Rotavirus Vaccine (Rotarix®) Immunogenicity Among Infants in Zambia Open
Live-attenuated, oral rotavirus vaccines have significantly reduced rotavirus-associated diarrhoea morbidity and infant mortality. However, vaccine immunogenicity is diminished in low-income countries. We investigated whether maternal and …
View article: Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data
Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data Open
View article: Use of an ETEC Proteome Microarray to Evaluate Cross-Reactivity of ETVAX® Vaccine-Induced IgG Antibodies in Zambian Children
Use of an ETEC Proteome Microarray to Evaluate Cross-Reactivity of ETVAX® Vaccine-Induced IgG Antibodies in Zambian Children Open
Developing a broadly protective vaccine covering most ETEC variants has been elusive. The most clinically advanced candidate yet is an oral inactivated ETEC vaccine (ETVAX®). We report on the use of a proteome microarray for the assessment…
View article: Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia
Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia Open
Background Shigella is a leading cause of bacterial diarrhea morbidity and mortality affecting mainly children under five in the developing world. In Zambia, Shigella has a high prevalence of 34.7% in children with diarrhea and an attribut…
View article: Assessment of the influence of ABO blood groups on oral cholera vaccine immunogenicity in a cholera endemic area in Zambia
Assessment of the influence of ABO blood groups on oral cholera vaccine immunogenicity in a cholera endemic area in Zambia Open
View article: Immediate and early engagement of same-day antiretroviral therapy initiation among newly diagnosed people living with HIV in urban Zambia: a retrospective cohort study
Immediate and early engagement of same-day antiretroviral therapy initiation among newly diagnosed people living with HIV in urban Zambia: a retrospective cohort study Open
Introduction: as Zambia moves towards attaining human immunodeficiency virus (HIV) epidemic control, it is clear significant efforts are required to facilitate achievement of UNAIDS treatment targets by 2030. To accelerate progress towards…
View article: Epstein–Barr Virus Detection in the Central Nervous System of HIV-Infected Patients
Epstein–Barr Virus Detection in the Central Nervous System of HIV-Infected Patients Open
Simply detecting Epstein–Barr virus deoxyribonucleic acid (EBV-DNA) is insufficient to diagnose EBV-associated diseases. The current literature around EBV-DNA detection from cerebrospinal fluid (CSF) in human immunodeficiency virus (HIV)-p…
View article: Immediate and Early Engagement of Same-Day Antiretroviral Therapy Initiation among newly diagnosed people living with HIV in Urban Zambia: A Retrospective Cohort Study
Immediate and Early Engagement of Same-Day Antiretroviral Therapy Initiation among newly diagnosed people living with HIV in Urban Zambia: A Retrospective Cohort Study Open
Introduction As Zambia moves towards attaining human immunodeficiency virus (HIV) epidemic control, it is clear significant efforts are required to facilitate achievement of UNAIDS treatment targets by 2030. To accelerate progress towards …
View article: Development of a diarrhoea severity scoring scale in a passive health facility-based surveillance system
Development of a diarrhoea severity scoring scale in a passive health facility-based surveillance system Open
Background Diarrhoeal disease remains a leading cause of death among children mostly in low and middle-income countries. Factors contributing to disease severity are complex and there is currently no consensus on a scoring tool for use in …
View article: Field evaluation of a novel, rapid diagnostic assay, and molecular epidemiology of enterotoxigenic E. coli among Zambian children presenting with diarrhea
Field evaluation of a novel, rapid diagnostic assay, and molecular epidemiology of enterotoxigenic E. coli among Zambian children presenting with diarrhea Open
Background Enterotoxigenic Escherichia coli (ETEC) is one of the top aetiologic agents of diarrhea in children under the age of 5 in low-middle income countries (LMICs). The lack of point of care diagnostic tools for routine ETEC diagnosis…
View article: Performance of Machine Learning Classifiers in Classifying Stunting among Under-Five Children in Zambia
Performance of Machine Learning Classifiers in Classifying Stunting among Under-Five Children in Zambia Open
Stunting is a global public health issue. We sought to train and evaluate machine learning (ML) classification algorithms on the Zambia Demographic Health Survey (ZDHS) dataset to predict stunting among children under the age of five in Za…
View article: Antimicrobial Susceptibility Patterns of Escherichia coli and Shigella Isolated from Stool Samples from Adults and Children in Zambia
Antimicrobial Susceptibility Patterns of Escherichia coli and Shigella Isolated from Stool Samples from Adults and Children in Zambia Open
Introduction Antimicrobial resistance (AMR) is a growing public health problem in low-to-middle income countries which have a high burden of infectious diseases. Poor antimicrobial stewardship in these regions has resulted in a rise in rep…
View article: Field evaluation of a novel, rapid diagnostic assay RLDT, and molecular epidemiology of enterotoxigenic <i>E. coli</i> among Zambian children presenting with diarrhea
Field evaluation of a novel, rapid diagnostic assay RLDT, and molecular epidemiology of enterotoxigenic <i>E. coli</i> among Zambian children presenting with diarrhea Open
Background Enterotoxigenic Escherichia coli (ETEC) is one of the top aetiologic agents of diarrhea in children under the age of 5 in low-middle income countries (LMICs). The lack of point of care diagnostic tools for routine ETEC diagnosis…
View article: T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review Open
Cellular immunity against rotavirus in children is incompletely understood. This review describes the current understanding of T-cell immunity to rotavirus in children. A systematic literature search was conducted in Embase, MEDLINE, Web o…
View article: Immunogenicity and waning immunity from the oral cholera vaccine (Shanchol™) in adults residing in Lukanga Swamps of Zambia
Immunogenicity and waning immunity from the oral cholera vaccine (Shanchol™) in adults residing in Lukanga Swamps of Zambia Open
Introduction In cholera endemic areas, the periodicity of cholera outbreaks remains unpredictable, making it difficult to organize preventive efforts. Lack of data on duration of protection conferred by oral cholera vaccines further makes …
View article: Immunogenicity and waning immunity from the oral cholera vaccine (Shanchol™) in adults residing in Lukanga Swamps of Zambia
Immunogenicity and waning immunity from the oral cholera vaccine (Shanchol™) in adults residing in Lukanga Swamps of Zambia Open
Introduction In cholera endemic areas, the periodicity of cholera outbreaks remains unpredictable, making it difficult to organize preventive efforts. Lack of data on duration of protection conferred by oral cholera vaccines further makes …
View article: Effect of HIV status and retinol on immunogenicity to oral cholera vaccine in adult population living in an endemic area of Lukanga Swamps, Zambia
Effect of HIV status and retinol on immunogenicity to oral cholera vaccine in adult population living in an endemic area of Lukanga Swamps, Zambia Open
Background We set out to assess the impact of human immunodeficiency virus (HIV) and micronutrient deficiency as indicated by serum retinol levels on the immune responses to Oral Cholera Vaccine (Shanchol™) in a cohort of participants in L…
View article: Machine Learning Algorithms For Understanding The Determinants of Under-Five Mortality
Machine Learning Algorithms For Understanding The Determinants of Under-Five Mortality Open
Background: The death rate of under-five children in India declined last few decades, but few bigger states have poor performance. This is a matter of serious concern for the child's health as well as social development. Nowadays, machine …
View article: Statistical Models for Estimating Linear Growth Velocity
Statistical Models for Estimating Linear Growth Velocity Open
Poor linear growth among infants is still a global public health issue. Linear growth velocity has been variously suggested as a more robust measure for growth over the classical measure of attained height for age. In this study, we system…
View article: Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia
Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia Open
Background Impaired growth among infants remains one of the leading nutrition problems globally. In this study, we aimed to compare the growth trajectory rate and evaluate growth trajectory characteristics among children, who are HIV expos…
View article: Mosquito-Borne Viral Pathogens Detected in Zambia: A Systematic Review
Mosquito-Borne Viral Pathogens Detected in Zambia: A Systematic Review Open
Emerging and re-emerging mosquito-borne viral diseases are a threat to global health. This systematic review aimed to investigate the available evidence of mosquito-borne viral pathogens reported in Zambia. A search of literature was condu…
View article: Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study
Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study Open
Introduction Shigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs). Knowledge on naturally acquired immunity can support the development of Shigel…