Bruno Gasnier
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View article: MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes Open
View article: MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes Open
Summary Lysosomal degradation of macromolecules in lysosomes produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here, we deorphanized the Major Facilitator Superfamily Domain Containing…
View article: Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism
Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism Open
Significance Lysosomes degrade and recycle cell components and integrate environmental and intracellular cues to regulate cell growth, metabolism, and autophagy. The lysosomal transporter PQLC2 exports cationic amino acids from lysosomes, …
View article: Free sialic acid storage disorder: Progress and promise
Free sialic acid storage disorder: Progress and promise Open
View article: Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters
Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters Open
Structures from the Stone Age can provide unique insights into Late Glacial and Mesolithic cultures around the Baltic Sea. Such structures, however, usually did not survive within the densely populated Central European subcontinent. Here, …
View article: Transporters in acidic organelles
Transporters in acidic organelles Open
View article: Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin
Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin Open
Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of exogenous sialic acids, leading to autoantibodies ag…
View article: Involvement of thapsigargin– and cyclopiazonic acid–sensitive pumps in the rescue of TMEM165‐associated glycosylation defects by Mn <sup>2+</sup>
Involvement of thapsigargin– and cyclopiazonic acid–sensitive pumps in the rescue of TMEM165‐associated glycosylation defects by Mn <sup>2+</sup> Open
Congenital disorders of glycosylation are severe inherited diseases in which aberrant protein glycosylation is a hallmark. Transmembrane protein 165 (TMEM165) is a novel Golgi transmembrane protein involved in type II congenital disorders …
View article: Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1
Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1 Open
View article: SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells
SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells Open
Significance Lysosomes are degradative intracellular organelles essential to cell maintenance and homeostasis. Although their degradative function is well documented, the proteins responsible for the efflux, and reuse, of lysosomal degrada…
View article: Watching the Pulleys Turn while the Elevator Moves in a Secondary Transporter
Watching the Pulleys Turn while the Elevator Moves in a Secondary Transporter Open