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View article: Approche biocatalytique pour la synthèse de lactames
Approche biocatalytique pour la synthèse de lactames Open
Biotechnology is now a well-established part of the chemical industry landscape. In the field of biocatalysis, there are numerous examples of the successful implementation of enzymatic steps in synthesis processes or the development of com…
View article: Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering
Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering Open
The CoA ligase from Metallosphaera sedula ( Ms ACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help o…