Oded Breuer
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View article: Diagnostic Evaluation and Clinical Findings in Children With Persistent Tachypnea of Infancy/Neuroendocrine Cell Hyperplasia of Infancy
Diagnostic Evaluation and Clinical Findings in Children With Persistent Tachypnea of Infancy/Neuroendocrine Cell Hyperplasia of Infancy Open
Diagnosis of PTI/NEHI relies on clinical symptoms and HRCT imaging results, with lung biopsies less commonly performed. Differences exist among countries regarding the number and type of investigations. A need exists for guidelines that wi…
View article: Infant Pulmonary Function Testing in Pediatric Diffuse Parenchymal Lung Disease
Infant Pulmonary Function Testing in Pediatric Diffuse Parenchymal Lung Disease Open
Topic Importance: Diffuse parenchymal lung disease (DPLD) in pediatrics, also known as children’s interstitial lung disease, comprises a diverse group of rare and chronic respiratory disorders affecting the pediatric population. Diagnosing…
View article: Changes in Sleep in Children and Adults with Cystic Fibrosis and Primary Ciliary Dyskinesia over Time and after CFTR Modulator Therapy
Changes in Sleep in Children and Adults with Cystic Fibrosis and Primary Ciliary Dyskinesia over Time and after CFTR Modulator Therapy Open
Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are associated with sleep disturbances affecting quality of life (QOL) in both children and adults. However, little is known about the progression of these complaints over time, and…
View article: Pulmonary Function Tests in Infants Following SARS-CoV-2 Infection
Pulmonary Function Tests in Infants Following SARS-CoV-2 Infection Open
Introduction : The clinical spectrum of SARS-CoV-2 infection is well-established. However, understanding its long-term implications, especially in infants, remains limited. We aimed to evaluate pulmonary function tests in infants (iPFT) se…
View article: Platelet count and risk of severe illness in hospitalised children with <scp>Influenza‐Like</scp> illness
Platelet count and risk of severe illness in hospitalised children with <span>Influenza‐Like</span> illness Open
Aim To examine the clinical significance of thrombocytosis (platelets > 500 × 10 9 /L) in admitted children with an influenza‐like illness. Methods We performed a database analysis consisting of patients evaluated at our medical centers wi…
View article: Pediatric respiratory admissions and related viral infections during the COVID‐19 pandemic
Pediatric respiratory admissions and related viral infections during the COVID‐19 pandemic Open
Introduction The COVID‐19 pandemic has affected the incidence of respiratory viral infections. Our aim was to assess changes in pediatric admissions due to respiratory diseases and associated respiratory viral infections. Methods An observ…
View article: Thrombocytosis - a Marker of Disease Severity in Children with Viral Respiratory Tract Infections
Thrombocytosis - a Marker of Disease Severity in Children with Viral Respiratory Tract Infections Open
Background : Reactive thrombocytosis (Platelets >500K/μl) is estimated between 3-13% in hospitalized children and has been associated with RSV infection and younger age. We aimed to examine the clinical significance of thrombocytosis in ch…
View article: The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study
The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study Open
Background Pulmonary disease is the leading cause of morbidity and mortality in people with cystic fibrosis (pwCF). Several studies have shown no benefit for bronchoscopy and bronchoalveolar lavage (BAL) over sputum to obtain microbiologic…
View article: The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis‐related diabetes
The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis‐related diabetes Open
Background Consistently abnormal glucose levels on oral glucose tolerance test (OGTT) are the most effective screening tool for cystic fibrosis‐related diabetes (CFRD). However, some cystic fibrosis (CF) patients demonstrate abnormal gluco…
View article: Respiratory physiotherapy in patients with Cystic Fibrosis and upper limb deep vein thrombosis
Respiratory physiotherapy in patients with Cystic Fibrosis and upper limb deep vein thrombosis Open
We report physiotherapy management of two patients with severe cystic fibrosis (CF) lung disease and upper limb deep vein thrombosis (DVT). These patients were admitted due to a pulmonary exacerbation. Following peripherally inserted centr…
View article: A screening tool to identify risk for bronchiectasis progression in children with cystic fibrosis
A screening tool to identify risk for bronchiectasis progression in children with cystic fibrosis Open
Background The marked heterogeneity in cystic fibrosis (CF) disease complicates the selection of those most likely to benefit from existing or emergent treatments. Objective We aimed to predict the progression of bronchiectasis in preschoo…
View article: A screening tool to identify risk for bronchiectasis progression in children with cystic fibrosis
A screening tool to identify risk for bronchiectasis progression in children with cystic fibrosis Open
Background: The marked heterogeneity in CF disease complicates selection of those most likely to benefit from existing or emergent treatments. Objective: We aimed to predict progression of bronchiectasis in preschool children with CF. Meth…
View article: Sleep in children with cystic fibrosis: More under the covers
Sleep in children with cystic fibrosis: More under the covers Open
Cystic fibrosis (CF) is a chronic multisystem disease with manifestations from birth. It involves the entire respiratory system, with increased cough, and recurrent pulmonary infections, and it also leads to intestinal malabsorption, all o…
View article: How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1
How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1 Open
Background Normal values (>80%) of Forced Expiratory Volume in one second (FEV1) in patients with Cystic fibrosis (CF) may lead to the interpretation that there is no lung disease.This study is a comprehensive analysis of lung involvement …
View article: Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia
Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia Open
The diagnosis of primary ciliary dyskinesia (PCD) relies on clinical features and sophisticated studies. The detection of bi-allelic disease-causing variants confirms the diagnosis. However, a standardised genetic panel is not widely avail…
View article: Structural determinants of long-term functional outcomes in young children with cystic fibrosis
Structural determinants of long-term functional outcomes in young children with cystic fibrosis Open
Background Accelerated lung function decline in individuals with cystic fibrosis (CF) starts in adolescence with respiratory complications being the most common cause of death in later life. Factors contributing to lung function decline ar…
View article: Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis
Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis Open
Rationale: Historical studies suggest that airway infection in cystic fibrosis initiates with Staphylococcus aureus and Haemophilus influenzae, with later emergence of Pseudomonas aeruginosa. Aspergillus species are regarded as relatively …
View article: Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study
Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study Open
CD48 is a costimulatory receptor associated with human asthma. We aimed to assess the significance of the soluble form of CD48 (sCD48) in allergic and nonallergic asthma. Volunteer patients completed an asthma and allergy questionnaire, sp…
View article: Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility
Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility Open
The clinical spectrum of ciliopathies affecting motile cilia spans impaired mucociliary clearance in the respiratory system, laterality defects including heart malformations, infertility and hydrocephalus. Using linkage analysis and whole …