Oded Heyman
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View article: Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC
Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC Open
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional …
View article: Excessive inflammatory response to infection in experimental peri‐implantitis: Resolution by Resolvin <scp>D2</scp>
Excessive inflammatory response to infection in experimental peri‐implantitis: Resolution by Resolvin <span>D2</span> Open
Aim The aetiology and pathogenesis of peri‐implantitis are currently under active research. This study aimed to dissect the pathogenesis of murine experimental peri‐implantitis and assess Resolvin D2 (RvD2) as a new treatment modality. Mat…
View article: Mutual interplay between IL-17–producing γδT cells and microbiota orchestrates oral mucosal homeostasis
Mutual interplay between IL-17–producing γδT cells and microbiota orchestrates oral mucosal homeostasis Open
Significance Elucidating the mechanisms by which homeostasis is established and maintained in the oral mucosa is important for human health. In this study we investigated the ontogeny and function of gingival γδT cells. The majority of the…
View article: Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants
Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants Open
Peri-implantitis is a destructive inflammatory process affecting tissues surrounding dental implants and it is considered a new global health concern. Human studies have suggested that the frequencies of Langerhans cells (LCs), the main an…
View article: Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis
Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis Open
Periodontitis is an infectious inflammatory disease of the supporting structures of the teeth. Resolvins are part of a large family of specialized pro-resolving lipid mediators that enhance active resolution of inflammation and return of i…
View article: Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation
Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation Open
Mucosal Langerhans cells (LCs) originate from pre–dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-ste…
View article: GAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa
GAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa Open
Significance Understanding the mechanisms by which the immune system and local microorganisms coexist in the oral cavity is important, as disruption of this delicate balance could cause oral and systemic diseases. We revealed that growth a…