Oded Shamriz
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Case Report: A potential novel treatment for drug-induced acute interstitial nephritis: Benralizumab Open
A 55-year-old man presented to the emergency department (ED) with diffuse abdominal pain, vomiting, and anuria following a night of heavy alcohol intake. The patient’s medical history included hypertension. Two weeks prior to presentation,…
View article: Benralizumab for adults with rare and off-label eosinophilic disorders: a 52-week prospective, single-center study
Benralizumab for adults with rare and off-label eosinophilic disorders: a 52-week prospective, single-center study Open
Background Rare eosinophilic disorders are challenging to manage due to their heterogeneity and lack of targeted therapies. Benralizumab, an anti-IL-5 receptor monoclonal antibody approved for the treatment of severe eosinophilic asthma an…
A Confirmatory Case of Severe Spondylocostal Dysostosis Caused by Biallelic Loss‐of‐Function of <span> <i>DMRT2</i> </span> Open
Spondylocostal dysostosis (SCDO) is a rare genetic disorder characterized by abnormal development of the axial skeleton, resulting in malformations of the vertebrae and ribs that often impair lung development and lead to significant respir…
View article: Metabolic reprogramming driven by Ant2 deficiency augments T Cell function and anti-tumor immunity in mice
Metabolic reprogramming driven by Ant2 deficiency augments T Cell function and anti-tumor immunity in mice Open
T cell activation requires a substantial increase in NAD+ production, often exceeding the capacity of oxidative phosphorylation (OXPHOS). To investigate how T cells adapt to this metabolic challenge, we generate T cell-specific ADP/ATP tra…
Case Report: Clinical manifestations of uncommon monogenic disorders: revisiting activated phosphoinositide 3-kinase delta syndrome 2 Open
Aim Pediatricians are trained to identify recurrent or unusual infections in children, prompting evaluation for inborn errors of immunity (IEI). Some monogenic IEI, however, may present atypically. This study describes our experience with …
Dual biological treatments in immune-mediated disorders: a single center experience Open
Dual biological treatment with omalizumab and another biologic appears to be safe, with no need to discontinue non-IgE-targeting agents during omalizumab therapy.
<span>IgE</span> deficiency (<2.5 <span>IU</span> / <span>mL</span> ) in children: Clinical insights from a population‐based study of 123,393 subjects Open
Background Immunoglobulin (Ig)E deficiency (<2.5 IU/mL) in adults is linked to higher risks of cancer and autoimmunity, but its significance in children remains unclear. This study evaluates the clinical importance of IgE deficiency in a n…
View article: Risk Factors for Developing Adenovirus‐Associated Post‐Infectious Bronchiolitis Obliterans
Risk Factors for Developing Adenovirus‐Associated Post‐Infectious Bronchiolitis Obliterans Open
Background Risk factors for progression of adenovirus (AdV)‐associated bronchiolitis (AdV‐B) to post‐infectious bronchiolitis obliterans (PIBO) are poorly defined. We aimed to investigate this in a multicenter cohort. Methods A multicenter…
Targeted inhibition of the IL5 axis for immune checkpoint inhibitors eosinophilic-induced adverse events Open
Given the broad implementation of immune checkpoint inhibitors (ICI) for cancer therapy, we encounter a variety of immune-related adverse events (irAE) including immune-related blood eosinophilia. Eosinophilia demonstrated a potential posi…
View article: Metabolic Reprogramming Driven by Ant2 -Targeting Augments T-Cell Function and Anti-Tumor Immunity
Metabolic Reprogramming Driven by Ant2 -Targeting Augments T-Cell Function and Anti-Tumor Immunity Open
T-cell activation requires a substantial increase in NAD + production, often exceeding the capacity of oxidative phosphorylation (OXPHOS). To investigate how T cells adapt to this metabolic challenge, we generated T cell-specific ADP/ATP t…
Food‐induced anaphylaxis during infancy is associated with later sleeping and eating disorders Open
Background Accumulating evidence suggests that food‐induced anaphylaxis (FIA) may induce different psychological disorders (PDs). In this study, we aimed to further evaluate the effect of FIA, specifically when occurring in early life, on …
Administration of BNT162b2 mRNA COVID-19 vaccine to subjects with various allergic backgrounds Open
Background The mRNA-based COVID-19 vaccine was introduced to the general public in December 2020. Shortly thereafter, safety concerns were raised due to the reporting of allergic reactions. Allergy-related disorders were suspected to be si…
Editorial: Rare immune-mediated diseases- novel insights into underlying mechanisms and therapeutic approaches Open
EDITORIAL article Front. Immunol., 14 August 2023Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1273062
View article: Novel targeted inhibition of the IL-5 axis for drug reaction with eosinophilia and systemic symptoms syndrome
Novel targeted inhibition of the IL-5 axis for drug reaction with eosinophilia and systemic symptoms syndrome Open
Background The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome represents a severe hypersensitivity reaction. Up-to-date treatment is based on withdrawal of medication, supportive care, and immunosuppression using hi…
Editorial: Dermatologic manifestations of primary immune deficiency disorders in children Open
EDITORIAL article Front. Pediatr., 31 March 2023Sec. Pediatric Immunology Volume 11 - 2023 | https://doi.org/10.3389/fped.2023.1182474
SARS-CoV-2 spike antibody concentration in gamma globulin products from high-prevalence COVID-19 countries are transmitted to X-linked agammaglobulinemia patients Open
Purpose Patients with X-linked agammaglobulinemia (XLA) are characterized by humoral impairment and are routinely treated with intravenous immunoglobulin (IVIG). In this study, we aimed to investigate the presence of severe acute respirato…
Increased rates of idiopathic inflammatory myopathies during the COVID-19 pandemic: a single-centre experience Open
The incidence of IIM increased during the COVID-19 pandemic. These patients display unique features and a more severe presentation. Fortunately, the prognosis remains unchanged.
View article: Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience
Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience Open
Background Autosomal dominant hyper-IgE syndrome (AD-HIES) caused by dominant negative (DN) variants in the signal transducer and activator of transcription 3 gene ( STAT3 ) is characterized by recurrent Staphylococcal abscesses, severe ec…
Genetics of Immune Dysregulation and Cancer Predisposition: Two Sides of the Same Coin Open
Approximately 10% of cancers have a hereditary predisposition. However, no genetic diagnosis is available in 60%-80% of familial cancers. In some of these families, immune dysregulation-mediated disease is frequent. The immune system plays…
Autoimmune Diseases Induced or Exacerbated by COVID-19: A Single Center Experience Open
The association between infectious diseases and autoimmunity has long been reported. Specifically, during the coronavirus disease 2019 (COVID-19) pandemic, this relation was further emphasized. The interplay between the two disease process…
View article: GATA2 Deficiency in Adult Life Is Characterized by Phenotypic Diversity and Delayed Diagnosis
GATA2 Deficiency in Adult Life Is Characterized by Phenotypic Diversity and Delayed Diagnosis Open
The transcription factor GATA2 plays a key role in the survival and self-renewal of hematopoietic stem and progenitor cells. Autosomal dominant variants in GATA2 cause a broad spectrum of heterogeneous phenotypes. Here, we present our expe…