Odile Dewit
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View article: A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M <sub>1</sub> receptor agonist HTL0018318 in patients with mild‐to‐moderate Alzheimer's disease
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M <sub>1</sub> receptor agonist HTL0018318 in patients with mild‐to‐moderate Alzheimer's disease Open
Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M 1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day. Me…
View article: Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double‐blind placebo‐controlled study
Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double‐blind placebo‐controlled study Open
Aims To explore the safety, tolerability, pharmacokinetics and pharmacodynamics (PD) of GSK2646264 using skin challenge models. Methods Healthy volunteers (HV) with a positive allergen skin prick test received GSK2646264 (0.5% or 1% ww) an…
View article: P3‐025: USE OF A MODIFIED HIDDEN PATHWAY MAZE TEST IN PATIENTS WITH ALZHEIMER'S DISEASE DEMENTIA
P3‐025: USE OF A MODIFIED HIDDEN PATHWAY MAZE TEST IN PATIENTS WITH ALZHEIMER'S DISEASE DEMENTIA Open
Maze tests have a long history as measures of visuospatial learning and executive function. The importance of impairments in both visuospatial learning and executive dysfunction has been increasingly recognized in early AD. In contrast to …