Odilo Engel
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View article: Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial
Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial Open
Background Ciclesonide is a glucocorticoid prodrug, already registered for human use. Due to its mode of action and inhaled route of administration, it was considered an appropriate treatment option for horses with severe equine asthma. Al…
View article: Short-term imepitoin treatment reduces stress level in dogs with generalized anxiety disorder
Short-term imepitoin treatment reduces stress level in dogs with generalized anxiety disorder Open
Dogs with generalized anxiety disorder exhibit constant or almost constant signs of anxiety and fear regardless of the context, impairing quality of life and daily functioning. In addition to behavior therapy, psychopharmacological interve…
View article: Development and Psychometric Validation of the Lincoln Canine Anxiety Scale
Development and Psychometric Validation of the Lincoln Canine Anxiety Scale Open
Introduction: Anxiety in dogs, especially in relation to certain noises, is a common issue which can lead to clinically significant problems like noise phobias. While several scales have been used to assess sound sensitivity and reactivity…
View article: Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs
Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs Open
Background Noise phobia is a common behavior problem in dogs for which there are limited treatment options. Objective To evaluate the efficacy and safety of imepitoin in comparison to placebo for the control of anxiety and fear associated …
View article: Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse
Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse Open
Systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality cont…
View article: Imepitoin Shows Benzodiazepine-Like Effects in Models of Anxiety
Imepitoin Shows Benzodiazepine-Like Effects in Models of Anxiety Open
Imepitoin is a low affinity partial agonist for the benzodiazepine binding site of γ-aminobutyric acid (GABAA) receptors, and is currently used as an antiepileptic in dogs. Here we tested imepitoin for anxiolytic properties. In an in vitro…
View article: Die Rolle des Parasympathikus in der Entstehung schlaganfallassoziierter Infektionen
Die Rolle des Parasympathikus in der Entstehung schlaganfallassoziierter Infektionen Open
Within the first three months after stroke onset up to 95% of stroke patients experience at least one relevant complication which has an important impact on survival. Infection is the most relevant complication with frequencies between 21 …
View article: Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke
Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke Open
LCN2 is expressed in the ischemic brain after temporary experimental ischemia and paralleled by the accumulation of cellular nonheme iron. Plasma levels of LCN2 measured in patients one week after ischemic stroke contribute to the predicti…
View article: Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke
Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke Open
Background and Purpose— Antibiotics disturbing microbiota are often used in treatment of poststroke infections. A bidirectional brain–gut microbiota axis was recently suggested as a modulator of nervous system diseases. We hypothesized tha…
View article: Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level
Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level Open
Pneumonia is the leading cause of death after acute spinal cord injury and is associated with poor neurological outcome. In contrast to the current understanding, attributing enhanced infection susceptibility solely to the patient's enviro…
View article: Blocking Stroke-Induced Immunodeficiency Increases CNS Antigen-Specific Autoreactivity But Does Not Worsen Functional Outcome after Experimental Stroke
Blocking Stroke-Induced Immunodeficiency Increases CNS Antigen-Specific Autoreactivity But Does Not Worsen Functional Outcome after Experimental Stroke Open
Stroke-induced immunodepression (SIDS) is an essential cause of poststroke infections. Pharmacological inhibition of SIDS appears promising in preventing life-threatening infections in stroke patients. However, SIDS might represent an adap…