Explanipedia

Distinct Adipocyte Responses to Δ9-Tetrahydrocannabinol (THC) Exposure Govern Hepatic Lipid Accumulation in an Obesogenic Setting Open

A. Eitan, Ofer Gover, Betty Schwartz · 2025

The effects of Δ9-tetrahydrocannabinol (THC) on adipocyte function under obesogenic, free-fatty-acid (FFA)-rich conditions remain poorly characterized, particularly regarding adipogenesis, FFA buffering, and downstream hepatocyte lipid han…

Impact of Black Soldier Fly Larvae Oil on Immunometabolic Processes Open

H. Richter, Ofer Gover, Amit Hamburg, Keren Bendalak, Tamar Ziv , et al. · 2025

The oil extract derived from black soldier fly (Hermetia illucens) larvae (BSFL) is characterized by a distinctive fatty acid composition and bioactive compounds with demonstrated anti-inflammatory properties, as shown in our previous work…

Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling Open

Saar Krell, Amit Hamburg, Ofer Gover, Kfir Molakandov, Gil Leibowitz , et al. · 2025

Precise regulation of insulin secretion by pancreatic β cells is essential to prevent excessive insulin release. Here, we show that the nutrient sensor mechanistic Target of Rapamycin Complex 1 (mTORC1) is rapidly activated by glucose in β…

Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis Open

Noga Korenfeld, Meital Charni‐Natan, Justine Bruse, Dana Goldberg, Dorin Marciano-Anaki , et al. · 2024

Mammals withstand frequent and prolonged fasting periods due to hepatic production of glucose and ketone bodies. Because the fasting response is transcriptionally regulated, we asked whether enhancer dynamics impose a transcriptional progr…

Peptide therapeutic leads for multi-target inhibition of inflammatory cytokines in Inflammatory Bowel Disease - computational design and in-vitro validation Open

Tomer Tsaban, Gali Kariv-Attias, Alisa Khramushin, Ofer Gover, Zvi Hayouka , et al. · 2024

Inflammatory Bowel Disease (IBD) are chronic and recurrent inflammatory disorders affecting the gastrointestinal tract, characterized by the involvement of numerous pro-inflammatory cytokines. These conditions profoundly impact both immune…

The Effect of Oil-Based Cannabis Extracts on Metabolic Parameters and Microbiota Composition of Mice Fed a Standard and a High-Fat Diet Open

A. Eitan, Ofer Gover, Liron Sulimani, David Meiri, Naama Shterzer , et al. · 2024

The prevalence of obesity and obesity-related pathologies is lower in frequent cannabis users compared to non-users. It is well established that the endocannabinoid system has an important role in the development of obesity. We recently de…

Phytocannabinoids Reduce Inflammation of Primed Macrophages and Enteric Glial Cells: An In Vitro Study Open

Gal Cohen, Ofer Gover, Betty Schwartz · 2023

Intestinal inflammation is mediated by a subset of cells populating the intestine, such as enteric glial cells (EGC) and macrophages. Different studies indicate that phytocannabinoids could play a possible role in the treatment of inflamma…

The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice Open

A. Eitan, Ofer Gover, Liron Sulimani, David Meiri, Betty Schwartz · 2023

Prolonged cannabis users show a lower prevalence of obesity and associated comorbidities. In rodent models, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) from the plant Cannabis sativa L. have shown anti-obesity properties, suggestin…

Phytocannabinoids Reduce Inﬂammation of Primed Macrophages and Enteric Glial Cells Open

Gal Cohen, Ofer Gover, Betty Schwartz · 2023

Inflammatory bowel diseases (IBD) includes Crohn's disease and ulcerative colitis, are idiopathic chronic relapsing inflammatory disorders of the intestinal tract. Different studies indicate that phytocanna-binoids, could play a possi…

Anti-Inflammatory Activity of Black Soldier Fly Oil Associated with Modulation of TLR Signaling: A Metabolomic Approach Open

H. Richter, Ofer Gover, Betty Schwartz · 2023

Dietary intervention in the treatment of ulcerative colitis involves, among other things, modifications in fatty acid content and/or profile. For example, replacing saturated long chain fatty acids with medium chain fatty acids (MCFAs) has…

Human Milk Oligosaccharide Profile across Lactation Stages in Israeli Women—A Prospective Observational Study Open

Adi Talan Asher, Laurence Mangel, Julius Ben Ari, Ofer Gover, Wiessam Abu Ahmad , et al. · 2023

Human milk oligosaccharides (HMOs) stimulate the growth of gut commensals, prevent the adhesion of enteropathogens and modulate host immunity. The major factors influencing variations in the HMO profile are polymorphisms in the secretor (S…

Beta-glucans induce cellular immune training and changes in intestinal morphology in poultry Open

Hadar Bar-Dagan, Ofer Gover, Natalie Avital Cohen, Václav Větvička, I. Rozenboim , et al. · 2023

Introduction Beta-glucans are known as biological response modifiers due to their ability to activate the immune system. This research aimed to determine the efficacy and safety of feeding beta-glucans from various sources on the immune st…

Critical Sites on Ostreolysin Are Responsible for Interaction with Cytoskeletal Proteins Open

Nastacia Adler Berke, Antonella Di Pizio, Timothy D. Vaden, Irit Shoval, Ofer Gover , et al. · 2022

We explored the structural features of recombinant ostreolysin A (rOlyA), a protein produced by Pleurotus ostreatus and responsible for binding to α/β-tubulin. We found that rOlyA cell internalization is essential for the induction of adip…

Recombinant ostreolysin (rOly) inhibits the anti-adipogenic Hedgehog (Hh) signaling pathway in 3T3-L1 cells Open

Erez Israeli, Nastacia Adler Berken, Ofer Gover, Eike Waechtershaeuser, Lutz Graeve , et al. · 2019

Enhanced Anti-Inflammatory Effects by Glucans Extracted from the Stalks of Pleurotus Eryngii Grown In Substrates Containing Olive Mill Waste Open

Betty Schwartz, Ofer Gover, Hilla Hayby, Adi Levy, Elena Fishman , et al. · 2019

We recently demonstrated that the mushroom Pleurotus eryngii grown on a substrate containing increasing concentrations of olive mill solid waste (OMSW) contain greater glucan concentrations as a function of OMSW content.Treatment of rat In…

Immune-modulating activities of glucans extracted from Pleurotus ostreatus and Pleurotus eryngii Open

Václav Větvička, Ofer Gover, Michal Karpovsky, Hilla Hayby, Ofer Danay , et al. · 2019

Spatial Distribution of Glucan Type and Content between Caps and Stalks in Pleurotus eryngii: Impact on the Anti-inflammatory Functionality Open

Václav Větvička, Ofer Gover, Hilla Hayby, Ofer Danay, Nirit Ezov , et al. · 2018

Pleurotus eryngii is recognized for its prominent nutritional and medicinal value. In our study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α. We demonstrated that glucan extracts are more effecti…

Expression of the entire polyhydroxybutyrate operon of Ralstonia eutropha in plants Open

Rita Mozes-Koch, Edna Tanne, Alexandra Brodezki, Ran Yehuda, Ofer Gover , et al. · 2017

Olive Mill Waste Enhances α-Glucan Content in the Edible Mushroom Pleurotus eryngii Open

Sharon Avni, Nirit Ezove, Hilla Hanani, Itamar Yadid, Michal Karpovsky , et al. · 2017

Mushroom polysaccharides are edible polymers that have numerous reported biological functions; the most common effects are attributed to β-glucans. In recent years, it became apparent that the less abundant α-glucans also possess potent ef…

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